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Flashcards in V - Diseases of the Immune System Deck (105)
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Indicate type of hypersensitivity reaction:Tuberculin reaction

Type IV(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


Indicate type of hypersensitivity reaction:Reactive arthritis

Type III(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


Indicate type of hypersensitivity reaction:Graves disease

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


Indicate type of hypersensitivity reaction:Acute rheumatic fever

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


Indicate type of hypersensitivity reaction:Myasthenia gravis

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


Indicate type of hypersensitivity reaction:Insulin resistant DM

Type II (TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


Indicate type of hypersensitivity reaction:Pernicious anemia

Type II(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.120


A special form of graft rejection occuring in the setting where preformed antidonor antibodies are present in the circulation of the host before transplant. Occurs within minutes to a few hours after transplantation.

Hyperacute rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133


Rejection which occurs within days to weeks of transplantation in a nonimmunosuppressed host. Caused by both cellular and humoral immune mechanisms.

Acute rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133


Acute rejection most commonly seen within the first months after transplantation, typically accompanied by signs of renal failure. Extensive CD4+ and CD8+ T-cell infiltration with edema and mild interstitial hemorrhage.

Acute cellular rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133


Acute rejection caused by antidonor antibodies. May take the form of necrotizing vasculitis with endothelial cell necrosis, neutrophilic infiltration, deposition of antibody, complement, and fibrin, and thrombosis.

Acute humoral rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133


Rejection which present clinically months to years after transplantation with a progressive rise in serum creatinine levels. Dominated by arteriosclerosis, interstitial fibrosis and loss of renal parenchyma.

Chronic rejection(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.133


A multisystem autoimmune disease which principally affects the skin, kidneys, serosal membranes, joints and heart. Associated with autoantibodies including ANAs.

Systemic Lupus Erythematosus(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.139


SOAP BRAIN MD mnemonic for SLE stands for?

SerositisOral ulcersArthritisPhotosensitivityBloodRenal disorderANA positiveImmunologic disorderNeurologic disorderMalar rashDiscoid rash(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.140


How many symptoms must be present in a patient for her/him to be diagnosed as having SLE?

4 out of 11 symptoms(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.140


Most serious and most common form of renal lesion in SLE. "Wire-loop" appearance of glomerular capillary walls.

Diffuse proliferative glomerulonephritis (Class IV)(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.142


Cardiac manifestation of SLE, which occurs as nonspecific mononuclear infiltrates and the presence of irregular 1-3mm warty deposits on either surface of the leaflets.

Libman-Sacks Endocarditis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.144


A systemic, chronic inflammatory disease affecting many tissues but principally attacking the joints to produce a nonsuppurative proliferative synovitis that frequently progress to destroy articular cartilage and underlying bone with resulting disabling arthritis.

Rheumatoid arthritis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.145


Characteristic lesion in RA, formed by proliferating synovial-lining cells admixed with inflammatory cells, granulation tissue and fibrous connective tissue.

Pannus(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.146


Cytokine which plays a central role in the pathogenesis of RA.

TNF(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.146


A clinicopathologic entity with a triad of dry eyes, dry mouth and arthritis.

Sjogren syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.148


Characterized by progressive fibrosis involving the skin, GIT and other tissues. May be a result of activation of fibroblasts by cytokines produced by T cells.

Systemic sclerosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.149


A vascular disorder characterized by reversible vasospasm of the arteries. Typically the hands turn white due to vasospasm, then blue due to cyanosis, then red due to reactive hyperemia.

Raynaud phenomenon(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.151


One of the more common forms of primary immune deficiency characterized by absent or markedly decreased numbers of B-cells in the circulation, with depressed serum levels of all classes if immunoglobulin.

X-linked agammaglobulinemia (Bruton disease)(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.152


Most common of all the primary immune deficiencies characterized by recurrent sinopulmonary infections and diarrhea.

Isolated IgA deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.154


A constellation of genetically distinct syndromes with common feature of defects in both humoral and cell-mediated immune responses, making affected infants susceptible to severe recurrent infections by bacteria, viruses, fungi, protozoans, and opportunistic infections.

Severe Combined Immunodeficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.154


Autosomal recessive form of SCID is due to deficiency of what enzyme?

Adenosine deaminase (ADA)(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.154


An X-linked recessive disease characterized by thrombocytopenia, eczema, and marked vulnerability to recurrent infection ending in early death.

Wiskott-Aldrich Syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.155


HIV viral surface proteins essential for viral entry into cells.

gp41 and gp120(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.157


A form of pneumonia in HIV patients caused by a yeast-like fungus.

Pneumocystis carinii pneumonia (PCP)(TOPNOTCH)