Vasculitis Flashcards
Target population for temporal arteritis.
Older women(> 65 y.o)
Arteries affected for temporal arteritis.
Large elastic arteries that branch from the aorta.
How does temporal arteritis look in section?
Panarteritis with a granulomatous inflammation first, then fibrosis.
What happens if there’s cranial arteritis in the opthalmic artery?
May have temporary blindness known as amaurosis fugax.
Causes ischemia of the optic nerve.
Prevents blindless.
Corticosteroids
Pain associated with temporal arteriosis.
Unilateral headaches where the artery is affected.
Arteries affected by polyarteritis nodosa.
Muscular arteries
Age group most affected by polyarteritis nodosa.
Young people, more common in men.
Part of the wall affected in polyarteritis nodosa.
Transmural.
What forms the nodes in polyarteritis nodosa?
Immune complexes (Hep B antigen).
Effects of polyarteritis nodosa on the vessels.
Thrombosis, infarction, ischemia.
Early lesions of polyarteritis nodosa have what?
Fibrinoid necrosis (the necrosis looks like fibrin).
Diseases associated with polyarteritis nodosa.
Polyneuropathy
Kidney disease
GI disease
This is EXTREMELY RARE in polyarteritis nodosa.
Pulmonary involvevment.
Skin lesion associated with Polyarteritis nodosa.
Livedo reticularis
ANCA
Anti-Neutrophil Cytoplasmic Antibody
ANCA-associated vasculopathies
The patient makes antibodies against the granules in their own polys, and the granules are released and cause vascular damage.
Types of ANCA antibodies.
c-ANCA and p-ANCA.
ANCA’s are made against _________.
Azurophilic granules.
A type of ANCA vasculitis.
Wegener’s
Wegener’s is AKA what?
Granulomatosis with Polyangiitis
Areas affected by Granulomatosis with Polyangiitis
Kidney, lung sinuses.
Most Wegener patients have this in their serum.
C-ANCA
Necrotizing vasculitis of small arteries and veins.
Granulomatosis with polyangiitis.
