Vasculitis

Question 1

Vasculitis is inflammation of what?

Answer 1

Blood vessels

Question 2

Which blood vessels does vasculitis affect?

Answer 2

Any

Question 3

Which type of vasculitis has the worst prognosis?

Answer 3

Small vessel

Question 4

What can cause secondary vasculitis?

Answer 4

Infection, drug, toxin, cancer

Question 5

Vasculitis causes systemic symptoms e.g. fever, weight loss, fatigue. True or false?

Answer 5

True

Question 6

What are the 2 types of large vessel vasculitis?

Answer 6

Takayasu Arteritis

Giant cell arteritis

Question 7

Which type of large vessel vasculitis affects those < 40 and is more common in females?

Answer 7

Takayasu Arteritis

Question 8

What race is Takayasu arteritis more common in?

Answer 8

Asians

Question 9

Which type of large vessel vasculitis affects those > 50?

Answer 9

Giant cell arteritis

Question 10

What vessel is most often involved in giant cell arteritis?

Answer 10

Temporal artery

Question 11

Temporal arteritis has an association with which other condition?

Answer 11

Polymyalgia rheumatica

Question 12

What is the major risk of temporal arteritis?

Answer 12

Blindness

Question 13

If there are symptoms of temporal arteritis, what test should you do? Should you always discount it if it comes back negative?

Answer 13

Temporal biopsy- there may be skip lesions so do not discount if negative

Question 14

What is the main treatment for giant cell arteritis?

Answer 14

Steroids (can consider sparing agents)

Question 15

What is the starting dose of steroids for giant cell arteritis?

Answer 15

40-60mg

Question 16

What are the two types of medium vessel vasculitis?

Answer 16

• Kawasaki Disease

- Polyarteritis Nodosa

Question 17

Who is Kawasaki disease seen in?

Answer 17

Children under 5

Question 18

What are the most important vessels to consider in Kawasaki Disease?

Answer 18

Coronary arteries

Question 19

Where in the vessels does polyarteritis nodosa affect?

Answer 19

Vessel bifurcations

Question 20

What other systems can polyarteritis nodosa affect?

Answer 20

Skin, gut, kidneys

Question 21

What condition is polyarteritis nodosa associated with?

Answer 21

Hep B

Question 22

Granulomatous inflammation of the respiratory tract, small and medium vessels. Necrotising glomerulonephritis is common. What condition is this?

Answer 22

Granulomatosis with polyangiitis

Question 23

Eosinophilic granulomatous inflammation of the respiratory tract, small and medium vessels. Associated with asthma. What condition is this?

Answer 23

Eosinophilic Granulomatosis with Polyangiitis

Question 24

Necrotising vasculitis with few immune deposits, necrotising glomerulonephritis is common. What condition is this?

Answer 24

Microscopic Polyangiitis

Question 25

Which sex is GPA more common in?

Answer 25

Males

Question 26

What is the typical age onset of GPA?

Answer 26

35-55

Question 27

Saddle nose is associated with which condition?

Answer 27

GPA

Question 28

EPGA is associated with asthma development when?

Answer 28

Later in life

Question 29

Which cases of vasculitis are ANCA +?

Answer 29

GPA EPGA MP

Question 30

Which subtype of ANCA is associated with GPA?

Answer 30

cANCA

Question 31

Which subtype of ANCA is associated with EGPA?

Answer 31

pANCA

Question 32

Does ANCA vary with disease activity?

Answer 32

Yes

Question 33

What happens to complement during disease activity?

Answer 33

Levels fall

Question 34

What is the treatment for localised and early systemic ANCA associated vasculitis?

Answer 34

Methotrexate and steroids

Question 35

What is 1st line treatment for generalised and systemic ANCA associated vasculitis?

Answer 35

Cyclophosphamide and steroids

Question 36

What is 2st line treatment for generalised and systemic ANCA associated vasculitis?

Answer 36

Rituximab and steroids

Question 37

What is the treatment for refractory ANCA associated vasculitis?

Answer 37

IV immunoglobulins and rituximab

Question 38

What usually precedes Henoch-Schonlein purpura?

Answer 38

UTI, pharyngeal or GI infection

Question 39

What is usually the cause of Henoch-Schonlein purpura?

Answer 39

Group A strep