Vasculitis

Question 1

most widely accepted pathogenic mechanism

Answer 1

immune complex deposition

Question 2

cANCA staining

Answer 2

diffuse granular cytoplasmic staining

Question 3

pANCA staining

Answer 3

localized perinuclear or nuclear staining pattern

Question 4

Major ANCA antigen cANCA

Answer 4

proteinase 3

Question 5

Major ANCA antigen pANCA

Answer 5

myeloperoxidase

Question 6

Granulomatous vasculitis of the upper and lower respiratory tracts + glomerulonephritis

Hallmark: necrotizing vasculitis of small arteries and veins

Answer 6

Wegener’s (Granulomatosis with polyangitis)

Question 7

Typical lung pathology in Wegener’s

Answer 7

nodular cavitary infiltrates

Question 8

Small vessel vasculitis

Answer 8

Wegener’s

Question 9

Kidneys, upper 95% and lower respiratory symptoms
chronic sinusitis
kidney: pauci immune GN
c ANCA + 90%
biopsy:
SADDLE NOSE deformity
necrotizing granulomatous vasculitis: lung
cyclophosphamide complete remission in 75%
+ GC

Answer 9

WEGENER’S

Question 10

Chronic nasal passage of _____ increases replace rate of Wegener’s

Answer 10

Staph aureus

Question 11

medium vessel vasculitis 
no lung involvement but involves bronchial vessels
NO GRANULOMA
mononeuropathy foot drop
kidneys: ARTERITIS WITHOUT GN
GI tract: aneurysms
Hep B 
p ANCA+ 
hAIRY CELL leukemia
Biopsy nerves

Answer 11

PAN -