Vasculitis ( PAN in other deck )

Question 1

pANCA, Necrotizing vasculitis of small vessels, Glomerulonephritis, Pulmonary Hemorrhage

Answer 1

Microscopic Polyangiitis

Question 2

How would you confirm a diagnosis of MPA ?

Answer 2

RBC Casts in the urine + pANCA + Biopsy

Question 3

Palpable Purpura, Arthritis, Abdominal Pain, Glomerulonephritis

Answer 3

HSP- That is the triad.

Question 4

Leukocytoclastic Vasculitis, What is this disease mediated by ?

Answer 4

HSP —-> IgA

Question 5

ENT LUNG and KIDNEY, Nose caving in, What is this disease and what is it mediated by ?

Answer 5

Wegener, cANCA

Question 6

Pauci-Immune Glomerulonephritis and Nodular Granulomas

Answer 6

Wegners, cANCA

Question 7

cANCA

Answer 7

Wegners

Question 8

Peripheral Neuropathy, Asthma, Eosinophilia —> what mediates this disease ?

Answer 8

This is Churg Strauss. It is mediated by pANCA.

Question 9

Polymyalgia Rheumatica and greatly increased sed rate —> what mediates this disease and a significant comorbidity ?

Answer 9

This is temporal arteritis. Consequence of aortic arch inflammation. BLINDNESS if not treated with steroids ASAP

Question 10

MI in a young asian child with cervical lymphadenopathy , beau’s lines and lymphocytosis?

Answer 10

Kawasaki- mucocutaneous lymphnode syndrome

Question 11

Aneurysms, bruise, and renovascular disease in a small asian child

Answer 11

Takayasu

Question 12

Transmural panarteritis + Granulomas in the internal elastic membrane. Skipping lesions

Answer 12

Temporal arteritis

Question 13

Pulselessness Disease, Nausea vomiting and ischemic bowel

Answer 13

Takayasu’s disease

Question 14

Jaw Claudification, Morning stiffness, blurred vision ?

Answer 14

Temporal arteritis

Question 15

Eosinophillic necrotizing granulomas and pANCA , Glomerulonephritis

Answer 15

Churgg Strauss,

Question 16

Hep B infection

Answer 16

PAN

Question 17

What are the most common findings in PAN ?

Answer 17

Fever and Weight Loss

Neuropathy

Arthritis / Myalgia / Arthralgia

Question 18

Are PAN and Cutaneous PAN the same thing ?

What is cutaneous PAN assicated with ?

Answer 18

No they are separate entities

Hep-C infection

Question 19

What is this ?

Answer 19

Nodular cavitating Lesion of Wegners

Question 20

What is this disease and what do you see ?

Answer 20

Vasculitis of arteries and veins, Granulamatous with polyangiitis

Question 21

What do you see here ?

Answer 21

Nodular Kidney Lesions —>Wegners

Question 22

What is this pathology and what disease is this associated with ?

Answer 22

Necrotizing vasculitis of the interlobular artery in the kidney

Wegners Vasculitis

Question 23

What is Churg Straus ?

Answer 23

Wegners but with tons of eosinophils

Question 24

What is this pathology and associated disease ?

Answer 24

This is necrotizing vasculitis with tons of eosinophils —> Red cytoplasm and BILOBED NUCLEI

Question 25

What is the pathogenesis of this disease ?

Answer 25

thromboangiitis obliterans is an inflammatory vaso-occlusive disease that predominantly affects the vascular supply to the lower limbs in young adult male tobacco smokers, although women and older adults can also be affected.

Question 26

Describe the pathological findings in Buergers disease

Answer 26

Segmental Transmural Inflammation without necrosis in the acute phase. In the chronic phase there will be organization and cannalization of the thrombus

Question 27

If a patient has this with gangreen on his hands is the disease acute or chronic and why ?

Answer 27

Chronic Buergers because the thrombus is organized

Question 28

Purpura, Abdominal Pain, arthritis and GN Arthralgias?

Answer 28

Heleno Schoen Purpura

Question 29

What is the pathology of HSP ?

Answer 29

Leukocytoclastic vasculitis

Question 30

What is this disease ?

Answer 30

This is the granuloma formation with Takasaku Arteritis

Question 31

What are the 4 aspects of the pathology to Takasaku Arteritis ?

Answer 31

1. Segmental 2. Transmural 3. Necrotizing 4. Loosly Granulamatous Multinucleated Giant Cells

Question 32

Describe this pathology

Answer 32

This is Transmural arteritis with a prominant granuloma narrowing the lumen of the vessel Temporal Arteritis

Question 33

Describe this pathology

Answer 33

Giant Cells eating up the internal elastic media. Temporal Arteritis