vasculopathies

Question 1

Sneddon syndrome sx

Answer 1

Stroke at young age

livedo reticularis

Question 2

Sneddon syndrome cause

Answer 2

Non-inflammatory med-small vessel vasculopathy

+ antiphospholipid Abs

Question 3

Bechet’s disease cause, sx

Answer 3

systemic inflammatory vasculitis (all vessel sizes)
Oral/genital ulcers, uveitis, non-erosive arthritis
Neuro sx (rare): Pyramidal/cerebellar

Question 4

CADASIL gene

Answer 4

Notch 3, chr 19

Question 5

CADASIL sx

Answer 5

Migraine with aura, TIA, mood disturbance and cognitive decline

Question 6

CADASIL imaging

Answer 6

lesions ant.temporal poles, external capsule, paraventricular WM

Question 7

Susac syndrome cause, population, sx

Answer 7

autoimmune microangiopathy
Young adult women
SN hearing loss
Branch retinal artery occlusion
encephalopathy

Question 8

Susac syndrome imaging

Answer 8

White matter lesions central portion corpus callosum

Question 9

Polyarteritis Nodosa sx

Answer 9

necrotixine vasculitis –>
nonspec sx (fever, wt loss), elevated LFTs
motor/sensory deficies +
kidney (HTN)
cardiac, GI
Skin - erythema nodosum, ulcerations, palpable purpura, livedo reticularis

Question 10

Takayasu Arteritis cause

Answer 10

Lg vessel granulomatous vasculitis
primarily aorta and its branches
intimal fibrosis and vascular narrowing

Question 11

Takayasu Arteritis population, sx

Answer 11

Asian young/middle age women
Nonspec sx + vertigo, syncope, HA
Tender carotid, absent/weak pulse, claudication
Skin: erythema nodosum or pyoderma gangrenosum