Vasoactive compounds and lipids Flashcards
release of vasoactive factors from sentinel cells contributes to
4 cardinal signs of acute inflammation
vasoactive compounds do what to the blood flow
slow blood flow down
what attracts blood platelets to damaged tissue
collagen and Von Willebrand Factor
what activates the blood platelets
thrombin
and releases clotting factors
when neutrophils enter inflammatory site what do they use
LOX to produce anti-inflammatory lipotoxins from arachadonic acid, which inhibits further neutrophil influx
COX1 and NF-kB inducible COX2 converts Arachadonic acid into
prostagladins
what are some prostagladins further converted into
thromboxane and prostacyclin
5-lipoxygenase (LOX) converts Arach acid into
leukotrienes
role of thromboxane
increase platelet aggregation
role of prostacyclins
promote vasodilation and inhibit platelet activation
prostagladins (PGE) can inhibit
LOX
how do neutrophils use LOX
to produce antiflammatory lipotoxins from Arach acid which inhibits further neutrophils influx from circulation
mast cell proteases act onnwhat complement components
C3 and C5
role of prokallikren
activated into kallikren
acts on kininogens
produces kinin peptides such as bradykinin
which then increases vasodilation and neutrophil activation
results in increased urination
example of a zymogen
prokallikrein
