Vasoactive Peptides

Question 1

Captopril Type & indication

Answer 1

HTN

Question 2

Captopril Contraindication

Answer 2

no ACE inhibitors in pregnancy due to renal damage of fetus

Question 3

Captopril MOA

Answer 3

ACE Inhibitor

Question 4

Captopril Route of Admin

Answer 4

oral

Question 5

Captopril Adverse Effects

Answer 5

severe stomach pain, chest pain, allergic reaction. Cough typical with ACE inhibitors.

Question 6

Captopril Notes

Answer 6

ACE is also a kininase, so when you block it, you see increased bradykinin, which is a vasodilator and is thought to be what causes cough in people.

Question 7

Enalapril Type & indication

Answer 7

HTN

Question 8

Enalapril Contraindication

Answer 8

no ACE inhibitors in pregnancy due to renal damage of fetus

Question 9

Enalapril MOA

Answer 9

ACE inhibitor

Question 10

Enalapril Route of Admin

Answer 10

oral

Question 11

Enalapril Adverse Effects

Answer 11

severe stomach pain, chest pain, allergic reaction. Cough typical with ACE inhibitors.

Question 12

Enalapril Notes

Answer 12

ACE is also a kininase, so when you block it, you see increased bradykinin, which is a vasodilator and is thought to be what causes cough in people.

Question 13

Losartan Type & indication

Answer 13

HTN

Question 14

Losartan Contraindication

Answer 14

no AT R-inhibitors in pregnancy due to risk of renal damage in fetus

Question 15

Losartan MOA

Answer 15

Angiotensin R-inh

Question 16

Losartan Route of Admin

Answer 16

oral

Question 17

Losartan Adverse Effects

Answer 17

diarrhea, insomnia, nasal congestion.

Question 18

Losartan Notes

Answer 18

Blocking the receptor does not block ACE action to breakdown kinins like bradykinin

Question 19

Valsartan Type & indication

Answer 19

HTN

Question 20

Valsartan Contraindication

Answer 20

no AT R-inhibitors in pregnancy due to risk of renal damage in fetus

Question 21

Valsartan MOA

Answer 21

Angiotensin R-inh

Question 22

Valsartan Route of Admin

Answer 22

oral

Question 23

Valsartan Adverse Effects

Answer 23

stomach pain, nausea

Question 24

Valsartan Notes

Answer 24

Blocking the receptor does not block ACE action to breakdown kinins like bradykinin

Question 25

Icatibant Type & indication

Answer 25

Inflammatory Responses

Question 26

Icatibant MOA

Answer 26

Bradykinin R inh

Question 27

Icatibant Route of Admin

Answer 27

oral

Question 28

Icatibant Adverse Effects

Answer 28

stomach pain, nausea

Question 29

Aprotonin Type & indication

Answer 29

Inflammatory Responses

Question 30

Aprotonin MOA

Answer 30

Kallikrein inh

Question 31

Aprotonin Route of Admin

Answer 31

IV

Question 32

Aprotonin Adverse Effects

Answer 32

MI, stroke, kidney failure

Question 33

Desmopressin (DDAVP) Type & indication

Answer 33

Diabetes insipidus, control of bleeding in Hemophilia A and classic vWF disease, also bedwetting

Question 34

Desmopressin (DDAVP) MOA

Answer 34

Increases(cAMP) in renal tubular cells which leads to decreased urine volume and increased urine osmolality; increases plasma levels of vWF, factor VIII, and t-PA

Question 35

Desmopressin (DDAVP) Drug Action/Pd

Answer 35

reduces urine volume and increase concentration.

Question 36

Desmopressin (DDAVP) Route of Admin

Answer 36

Intranasal or IV

Question 37

Desmopressin (DDAVP) Adverse Effects

Answer 37

Desmopressin +excessive fluid consumption =hyponatremia, which can lead to seizures, brain swelling, coma, and death

Question 38

Bosentan Type & indication

Answer 38

pulmonary hypertension

Question 39

Bosentan MOA

Answer 39

endothelin R-inhibitor

Question 40

Bosentan Adverse Effects

Answer 40

liver problems, stomach pain, nausea