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Block 6 > VBS 2 Pharm > Flashcards

VBS 2 Pharm Flashcards

1
Q

Monensin classification

A

ionophore, coccidiostat

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2
Q

Monensin MOA

A
  • Na+ selective - makes complex to cross cell membrane
  • decrease levels of butyrate, acetate
  • increase levels of propionate
  • selectively kills methane-producing bacteria
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3
Q

Amprolium classification

A

ionophore, coccidiostat

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4
Q

Amprolium MOA

A

mimics the structure of thiamine - acts as a competitive inhibitor
*excess causes thiamine deficiency -> polioencephalomalacia
*not commonly used anymore

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5
Q

Tetracycline characterizations

A
  • broad spectrum [gram(+) > gram(-)]
  • time-dependent
  • bacteriostatic
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6
Q

Tetracycline MOA

A

reversibly binds to 30S ribosomal subunit

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7
Q

Tetracycline ADME

A

A: readily absorbed PO in fasted animals
D: widely distributed = lipophilic (can cross placenta, but not CNS)
M: renal??
E: unchanged in urine and feces

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8
Q

Lincomysin classification

A
  • lincosamide antibiotic
  • broad spectrum (primary use for gram(+) aerobic cocci, but can also be used for many anaerobes
  • time-dependent
  • bacteriostatic (-cidal at high conc.)
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9
Q

Lincomysin MOA

A

reversibly binds to 50S ribosomal subunit

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10
Q

Lincomysin ADME

A

A: well absorbed PO and IM
D: wide distribution = lipophilic
M: liver
E: urine, feces, bile

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11
Q

Ampicillin classification

A
  • penicillin antibiotic - Beta lactam antibiotic
  • broad spectrum
  • time-dependent
  • bactericidal
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12
Q

Ampicillin MOA

A

irreversibly binds to PBPs - causing cell lysis

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13
Q

Ampicillin ADME

A

A: PO - bad, parenteral - good
D: wide distribution, crosses placenta
M: ?
E: renal excretion

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14
Q

Fenbendazole classification

A
  • benzimidazole
  • antinematodal, antiprotozoal
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15
Q

Fenbendazole MOA

A

t-tubulin disruption -> parasite paralysis

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16
Q

Fenbendazole ADME

A

A: PO, not well absorbed, but can increase bioavailability when given with food
D: widely distributed, can appear in milk, but no CNS
M: liver via microsomal flavin mono-oxygenase
E: feces

Block 6 (7 decks)

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