Vecuronium

Question 1

Vecuronium- Name

Answer 1

Norcuron

Question 2

Vecuronium- Class

Answer 2

Nondepolarizing skeletal muscle relaxant

Question 3

Vecuronium- MoA

Answer 3

Inhibits neuromuscular transmission by competitively binding with acetylcholine motor endplate receptors resulting in muscle paralysis.

Question 4

Vecuronium- Indications

Answer 4

pharmacologically assisted endotracheal intubation

or RSI

Question 5

Vecuronium- Contra

Answer 5

use with caution in patients with severe hepatic disease, impaired electrolyte balance

use with caution with severe cardiovascular disease

Question 6

Vecuronium- S/E

Answer 6

CNS: residual skeletal muscle weakness

Respiratory: respiratory depression

Other: Malignant Hyperthermia

Question 7

Vecuronium- Routes

Answer 7

IV, IO

Question 8

Vecuronium- A. Dose

Answer 8

0.08 – 0.10 mg/kg

Question 9

Vecuronium- P. Dose

Answer 9

(> 1 year): 0.08 – 0.10 mg/kg

Question 10

Vecuronium- EXTRAS

Answer 10

Precautions: Pregnant or Nursing mothers, patients with myasthenia gravis

Interactions:

1) Diuretics may increase or decrease neuromuscular blockade
2) narcotic analgesics increase respiratory depressant effects
3) phenytoin (Dilantin®㋿) may cause resistance to neuromuscular blockade

Onset < 1 minute, peak effects in 3-5 min, duration 25-40 mins.