Venous thromboembolism

Question 1

what is virchow’s triad

Answer 1

triangle of cause for thrombosis
you can have 1,2 or all of the causes
the causes are stasis, hypercoagulability and vascular injury

Question 2

describe the coagulation cascade (extrinsic pathway)

Answer 2

extrinsic tenase kickstarts the clotting cascade by generating a fast burst of factor 10
factor 10 then generates thrombin
thrombin cleaves fibrin peptides fibrinogen and creates a stable fibrin plug
this is a very fast pathway

Question 3

describe coagulation cascade (intrinsic tenase)

Answer 3

consolidation of the plug occurs through the generation of thrombin through a slower pathway
calcium must be present