Ventilatory Support Hypoxaemic - (2a) Flashcards

1
Q

What is hypoxaemic respiratory failure?

A

Inadequate transfer of 02 into blood, inadequate 02 transport, Extraction/utilisation problems

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2
Q

What can cause Inadequate transfer of 02 into blood?

A

Problems with perfusion. - eg emboli

Inadequate fresh air reaching gas exchange area
Reduced SA for gas exchange
Diffusion problems

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3
Q

What could cause inadequate O2 transport?

A

Hb

Inadequate circulation

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4
Q

What is a diffusion problem?

A

Gas is going in but can’t diffuse across into capillaries

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5
Q

What needs to be resolved to increase PaO2?

A

Increased diffusion

Or Increased surface area (FRC

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6
Q

Medical treatments to increase diffusion

A

Oxygen therapy ( To Increase F1O2, Increased PastmosO2 -(atmospheric pressure))

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7
Q

What are medical methods to increase surface area (FRC)?

A

PEEP

CPAP

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8
Q

What can a ventilator deliver? What can be done if that is not high enough?

A

F1O2 0.21 - 1.0

For patients requiring high F102, its more appropriate to use strategies such as high PEEP or other support modalities if available ( eg HFOV, NO, ECMO)

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9
Q

What could a hyperbaric oxygen chamber be used for

A

The bends
Elite athletes
Severe wounds

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10
Q

What is a normal dose of PEEP?

A

5-7.5 cm

If gas diffusion problem, up to 15 cm PEEP.

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11
Q

What is CPAP?

A

Continuous positive airway pressure

Pressure positive at the mouth during both inspiration and expiration
Used for spontaneous breaths

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12
Q

What is PEEP?

A

Positive end expiratory pressure

Pressure may be negative during inspiration
Usually used in relation to ventilator breaths

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13
Q

What are the three things that can be supported when breathing?

A

Volume
Flow
Pressure

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14
Q

What is different about the pressure graph for CPAP?

A

Don’t come back down to atmospheric pressure. Come back to whatever has been dialled in.

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15
Q

What does positive airway pressure on expiration do?

A

Reduces alveolar emptying which increases alveolar size (inc. FRC) thus increasing gas exchange surface area

Re expand collapsed alveoli (recruitment) therefor increases number of alveoli participating in gas exchange

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16
Q

What is ECMO?

A

Extracorporeal membrane oxygen.

Cardiopulmonary support provided outside the body
Using artificial heart and/or lung support

Eg cardiac surgery bypass type machine

17
Q

What is nitric oxide?

A

Inhaled NO is a selective pulmonary vasodilator
Improves absorption of oxygen (not not overall survival) not all patients are “responders”

Relatively costly to set up, cheap to run.

18
Q

Complications of nitric oxide

A

NO3 formation (toxic) when combined with atmosphere
Met-haemoglobin levels increase
Environmental contamination

Problems:
Transporting patients while on NO
rebound effect when weaning

19
Q

What is HFOV?

A

High frequency oscillatory ventilation

20
Q

What is HFJV

A

High frequency jet ventilation

21
Q

Uses of HFOV

A

Adults with ARDS improves gas exchange

Neonates

Small tidal volumes 1-3 ml/kg delivered at high frequencies gas exchange occurs by convection - high PEEP/MAP

Two recent RCT showed negative outcomes compared with conventional ventilation

22
Q

What is NAVA

A

Neurally adjusted ventilatory assistance

Diaphragm electrical activity measured with an oesophageal probe controls the assistance delivered by the ventilator (rather than airway pressures or volume as trigger)

23
Q

Complication of NAVA

A

Respiratory muscles will waste and need to go through exercise program