vesiculobollous disorders

Question 1

Auto-immune blistering disease of the skin & mucus membranes

Answer 1

pemphigus

Question 2

histologic char of pemphigus

Answer 2

Intraepidermal blisters due to

acantholysis.

Question 3

loss of intercellular connections, such as desmosomes,

resulting in loss of cohesion between keratin

Answer 3

Acantholysis

Question 4

DIF vs Biopsy

Answer 4

in DIF sample besudes the blister or normal perilesional skin; Biopsy sample from early vesicle

Question 5

Most superficial type of Pemphigus

Answer 5

PEMPHIGUS FOLIACEUS

Question 6

Localized form of PF

Answer 6

Pemphigus erythematosus

Question 7

presents with oral lesions in over 50% of patients. Oral lesions (buccal involvement) may be the only manifestation of the disease

Answer 7

PEMPHIGUS VULGARIS (PV)

Question 8

epidermal separation in this disease occurs low in the epidermis
• “row of tombstone”

Answer 8

PV

Question 9

Autoimmune blistering disease linked to a lymphoproliferative disorder (non-Hodgkins Lymphoma, Chronic Lymphocytic Leukemia)

Answer 9

PARANEOPLASTIC PEMPHIGUS

Question 10

DIF in paraneoplastic pemphigus

Answer 10

intracellular epidermal IgG and C3

Question 11

Recurrent vesicles and erosions of familiial benign pemphigus particularly are on

Answer 11

flexural

areas (submammary regions, inguinal folds, scrotum

Question 12

Autoimmune subepidermal blistering diseases

Answer 12

pemphigoid

Question 13

Subepidermal blistering disease; Large, tense pruritic blisters; Seen in flexural areas

Answer 13

BULLOUS PEMPHIGOID (BP)

Question 14

DIF of BP

Answer 14

linear band of C3 and IgG on EBM

Question 15

why BP has (-) N sign

Answer 15

bcoz it is deep down the dermis

Question 16

Desmosomal plaque protein that
is important in anchoring keratin intermediate
filaments to the desmosome.

Answer 16

Desmoplakin 1:

Question 17

elderly patient
Large tense blisters
(-) Nikolsky sign
(+) pruritus
Mucous membrane spared
Flexural areas affected

Answer 17

BP

Question 18

Rare, subepidermal blistering disease of the skin & mucous membranes

Answer 18

LINEAR IGA DERMATOSIS (LAD) & CHRONIC

BULLOUS DISEASE OF CHILDHOOD (CBDC)

Question 19

cluster of jewel”, “collarette of blisters

Answer 19

LINEAR IGA DERMATOSIS (LAD) & CHRONIC

BULLOUS DISEASE OF CHILDHOOD (CBDC)

Question 20

Immunohistopatholigic findings of LAD and CBDC

Answer 20

homogenous band of

IgA on the DEJ

Question 21

DIF of LAD

Answer 21

Linear deposition of IgA

Question 22

Rare, polymorphic inflammatory, subepidermal bullous

dermatosis of pregnancy (4th-7th month

Answer 22

PEMPHIGOID GESTATIONIS (PG) (HERPES GESTATIONIS

Question 23

DIF of PEMPHIGOID GESTATIONIS (PG) (HERPES GESTATIONIS

Answer 23

linear deposit of C3 along DEJ

Question 24

Intensely itchy chronic papulovesicular eruption

• Symmetric, tiny vesicles, papules, and urticarial plaques arranged in groups

Answer 24

DERMATITIS HERPETIFORMIS

Question 25

DIF of Dermatitis herpetiformis

Answer 25

Granular PAPILLARY deposits of IgA

Question 26

Vesicles and erosions of dermatitis herpetiformis are commonly found where

Answer 26

on the buttocks

Question 27

biopsy of dermatitis herpetiformis shows

Answer 27

Subepidermal clefts with microabscesses of neutrophils and eosinophils in the dermal papillae

Question 28

Rare, chronic auto-immune subepidermal blistering disease with erosive lesions

Answer 28

CICATRICIAL PEMPHIGOID

Question 29

Conjunctiva and oral mucosa: most common areas affected by this

Answer 29

CICATRICIAL PEMPHIGOID

Question 30

DIF of Cicatricial pemphigoid

Answer 30

Linear deposits of IgG and C3 on BMZ