Viral Flashcards

(53 cards)

1
Q

Does trump know about biopreparat?

A

Not unless Fenger has been emailing him or tweeting at him since taking office

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2
Q

replication togavirus

A

cytoplasm

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3
Q

characteristics togavirus

A

ss+RNA
icosahedral bapsids
envelope with glycoprotein spikes on surface

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4
Q

infectious process togavirus

A
URT
long incubation period (2-3 weeks)
viremia
macular-papular rash lasts 3 days 
enlargement of LN (behind ears)
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5
Q

sequela from togavirus

A

arthritis in females

congenital infections

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6
Q

season for rubellavirus

A

spring

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7
Q

rubellavirus of fetus

A

does not cause lytic infection

prevents normal growth of tissue and chromosomal damage

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8
Q

abnormalities seen in fetus from rubella

A
mental retardation
cataracts
deafness
hepatosplenomegaly
heart and vessel defects
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9
Q

diagnosis rubella newborn

A

anti-viral IgM

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10
Q

diagnosis rubella in adults

A

paired sera show 4x increase from day 7 to 17

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11
Q

vaccination rubella goals

A

vaccinate women of childbearing age

vaccinate children>12 months

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12
Q

vaccination form

A

attenuated virus

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13
Q

genera parvoviridae

A

dependovirus and eryhtrovirus

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14
Q

dependoviruses

A

require helper virus to replicate

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15
Q

infections from erythrovirus B19

A

slapped cheek, macular papular rash

Fifths disease

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16
Q

characteristics parvoviridae

A

smalles
icosahedral capsid, lack envelope
ssDNA

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17
Q

replication parvo

A

dependent on actively dividing host cells

NS1 and NS2 promote replicaiton cycle

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18
Q

hydrops fetalis

A

from accumulation of fluid in abdomen and subcutaneous tissues

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19
Q

diagnosis parvo infection

A

IgM for B19

NAAT of fetal blood

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20
Q

elevated rate of fetal CMV infection

A

in females with lowered T cell responses to CMV antigens

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21
Q

reactivation CMV infections in mother

A

does not lead to fetal abnormalities

seen most frequently in last trimester when fetal development has been established

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22
Q

diagnosis CMV

A

anti-CMV IgM or NAAT

virus isolation possible from throat swabs and urine samples

23
Q

malformations from varicella

A

limbs and muscles

24
Q

malformations from HIV

A

weight deficient, thrush, hepatosplenomegaly, diarrhea

CNS and AIDs symptoms may be evident in newborn

25
recommendations for HIV mother
anti-HIV drugs | C-section and not breast feeding
26
e antigen positive Hep B
high levels in blood and bodily fluids | can be transmitted to fetus
27
treatment anti HBV for children
anti-HBV in utero or perinatally | also pegylated interferon
28
prevention and control HBV for children
vaccinated immediately after birth | hyper-immune globulin
29
zika
member flaviviridae along with dengue and yellow fever
30
transmission zika
sexual intercourse and blood transfusions in addition to mosquito bites
31
symptoms zika
fever, rash, joint pain, inflamed eyes
32
serological testing and RT-PCR zika
RT-PCR serum in first 2 weeks, urine within 14 days | IgM detectable after 1 week
33
vector zika
aedes aegypti and aedes albopictus
34
SV40
papovavirus can cause lytic infection or transformation tumor virus
35
lytic infection SV40
T and t are regulator proteins and bind to viral DNA | late messenger into late (capsid)
36
transformation SV40
T and t antigens cause transformation of cells (loss of contact inhibition, replicate with lower growth factor requirement)
37
nonpermissive cells
transformation
38
permissive cells
lytic
39
HPV 1 and 3
plantar warts
40
HPV 2, 3, 10
warts on knees and fingers
41
infection papillomavirus
basal layer of skin but replication only occurs in these cells as they differentiate
42
treatment skin papillomas
podophyllin (extract of mandrake)
43
HPV vaccine
HPV L1 protein (capsid protein) genetically engineered into yeast vector 6,11,16,18+aluminum adjuvant
44
catch up vaccination
if 13-26 yo
45
diagnosis HPV
nucleic acid based analyses to determine HPV type and viral load
46
transmission HIV
``` blood semen vaginal secretions tissue transplants breast milk ```
47
resource rich HIV transmission
MSM primary mode
48
resource poor HIV transmission
heterosexual intercourse
49
transmission HBV
blood and blood products sexual intercourse mother to fetus/child
50
incubation time HSV
3-7 days
51
reactivation of HSV2 infections
changes in immune system, X irradiation, chemo, stress, infections
52
diagnosis HSV
specific antibodies with immunofluorescence
53
treatment HSV
acyclovir, valaciclovir, famciclovir are nuceloside analogs