Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

microbiology 3 > viral arthropathies > Flashcards

viral arthropathies Flashcards

(66 cards)

Start Studying
1
Q

arthralgia

A

pain in the joints

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

arthritis

A

inflammation of the joint with the presence of inflammatory cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

arthropathy

A

something wrong with the joint that may or may not be arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

arthritogenic

A

something that tends to cause arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

monoarthritis

A

a single joint infected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

oligoarthritis

A

2 or 3 joints affected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

polyarthritis

A

lots of joints affected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

migratory arthritis

A

one joint is affected and then resolves, pain moves onto another joint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

differential diagnosis of joint pain

A

bacterial, viral, postinfectious, crystal arthropathy, rheumatological diseases, osteoarthritis, trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

viruses commonly causing arthropathy

A

arboviruses
rubella virus
parvovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

viruses that rarely cause arthropathy

A

hepatitis viruses and HIV
herpesvirus
enteroviruses
adenoviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

arboviruses

A

arthropod borne viruses
transmitted via arthropod vector, usually mosquito
- flavivirus (RNA)
- alphavirus (RNA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

flavivirus

A

yellow fever virus (viscerotropic)

eg. dengue, zika, neuurotopric (encephalic) viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

dengue

A

most common flavivirus infection worldwide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

zika

A

caused an epidemic in south and central america

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

neurotropic flavivirus

A

tend to cause infection of the CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

australia neurotropic viruses

A

murray valley encephalitis

kunjin virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

non australian flaviviruses

A

japanese encephalitis virus
west nile virus
st louis encephalitis virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

alphaviruses

A 
arthritogenic 
- ross river 
- barmah forest virus 
- chikungunya 
neurotropic 
- western equine encephalitis virus 
- eastern equine encephalitis virus 
- venezuelan equine encephalitis virus 
- mayaro (arthritogenic)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

dengue virus transmitted by

A

aedes aegypti

also aedes albopictus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

dengue infects

A

maintained in human populations

can infect non human primates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

dengue seotypes

A

4 serotypes which co circulate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

dengue incubation period

A

3-14 days after mosquito bite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

clincal manifestations of dengue

A

fever
headache, eye pain, myalgia, arthralgia
rash, usually 2-5 days after symptom onset
GI symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
dengue lab resullts
abnormal LFTs, low platelets serology for diagnosis - NS1 antigen and IgM and IgG antibodies nucleic acid testing (PCR) also works for diagnosis
26
severe dengue
formerly dengue haemorrhagic fever and dengue shock syndrome more common in secondary than primary dengue infection plasma leakage, heamorrhage, shock critical period 3-7 days after symptom onset
27
dengue treatment
supportive care only careful fluid management in severe dengue vaccine development hampered by antibody dependant enhancement
28
Zika transmitted by
Ae. aegypti, Ae. albopictus
29
Zika incubation period
2 - 14 days
30
clinical manifestations of Zika
similar to dengue but milder 50-75% of infections are asymptomatic conjunctivitus is common in symptomatic infection
31
lab diagnosis of zika
serology for igM and IgG antibodies definitive diagnosis can be difficult due to cross reactivity with other flaviviruses nucleic acid testing
32
treatment of zika
supportive care only
33
person to person transmission in Zika
sexual and vertical transmission possible
34
neurotropism of zika
microcephaly and other neurological abnormalities from intrauterine infection causes guillain barre syndrome
35
ross river and barmah forest viruses
most common causes of viral polyarthritis in australia regular epidemics with a geographical focus distributed throughout australia, also found in melanesia multiple mosquito vectors infection is enzootic in native macropods (kangaroos, wallabies), can also infect horses, livestock, other wild animals
36
incubation period for ross river and barmah forest
3-21 days
37
clinical manifestationss of ross river and barmah forest viruses
arthralgia fatigue rash fever and myalgia
38
arthralgia in ross river and barmah forest viruses
athralgia is usually symmetrical, affects wrists, knees, ankles, MCP/IP joints of the hands may persist for 3-6 months
39
lab diagnosis for ross river and barmah forest
serology for IgM and IgG | nucleic acid testing
40
treatment for ross rver and barmah frest
supportive care only
41
chikungunya virus vectors
prmary vectors are Ae. aegypti and Ae. albopictus
42
chikungunya virus incubation period
incubation period 1-14
43
chikungunya virus clinical manifestations
fever arthralga rash headache, myagla, GI symptoms
44
althralgia in chickungunya vrus
usually 2-3 days after fever onset, similar distribution to other alphaviruses can be debilitating, gradually mproves over 3-18 months
45
lab diagnosis of chikungunya
serology for IgM and IgG | nucleic acd testing
46
treatment for chikungunya
supportive care only
47
rubella caussed by
rubella virus (RNA)
48
rubella incubation period
14-18 days
49
rubella tranmission
person to person via large respiratory droplets
50
clinical manifestations in children of rubella
often mild or asymptomatic distinctive rash spreads from face to trunk and extremities within 24 hours, lasts 3-8 days low grade fever and lymphadenopathy pay precede the rash
51
clinical manifestations of rubella in adults
rarely asymptomatic prodrome with fever and lymphadenopathy more pronounced, followed by rash arthralgia reported in 70% of adult women, concurrent with rash - may persist for 1-2 months - knees, wrists, fingers most frequently involved
52
lab diagnosis of rubella
serology IgM and IgG anitbodies | nucleic acid testing (PCR)
53
treatment for rubella
supportive care only
54
rubella in pregnancy
transplacental infection may occur greatest risk in first trimester, minimal after 20 weeks gestation intrauterine infection may lead to fetal loss or congental rubella syndrome
55
congenital rubella syndrome
hearing loss intellectual impairment cardiac abnormalities cataracts
56
rubella precautions in pregnancy
testing for rubella immunity routinely recommended in pregnancy; post-pregnancy booster if IgG is low post exposure prophylaxis in pregnancy has not been shown to be beneficial confirmed cases managed by maternal-fetal medicine
57
parvovirus
parvovirus B19 small DNA virus with global dictribution, first isolated in australia causes another childhood exanthem 'fifth disease' 50% infected by age 15 transmission person to person by large respiratory droplets incubation period 1-2 weeks
58
clinical manifestations of parvovirus
25% asymptomatic 50% have mild, non-specific illness (fever, myalgia, coryza, headache) 25% present with erythema infectiosum or arthralgia
59
erythema infectosum
usually seen in children erythematous malar rash with circumoral pallor (slapped cheek syndrome) follows 2-5 days after prodrome generalised rash follows
60
athralgia in parvovirus
mainly adults, especially women affects hands, wrists, knees, feet symmetrically usually lasts three weeks generalised rash in 75% of cases
61
other manifestations of parvovirus
aplastic crisis in haematological disorders | chronic haemolysis in immunocompromised patients
62
lab diagnosis of parvovirus
serology for IgM and IgG antibodies | nucleic acid testing (PCR)
63
parvovirus treatment
supportive care only | no vaccine or post exposure prophylaxis exists
64
parvovirus in pregnancy
transplacental infection may occur may lead to fetal loss or fetal hydrops - parvovirus is cytotoxic too fetal red blood cell precursors greatest risk prior to 20 weeks confirmed infection in pregnancy managed by maternal-fetal medicine - fetal blood transfusion may be used to treat fetal hydrops
65
pathogenesis of viral arthropathy
not well understood not simply viral replication in the joints at least partially immune mediated virus has occasionally been cultured from joint aspirates - viral antigens and nucleic acid detected more commonly - viral inclusions have been seen in joint macrophages immune complex deposition thought to contribute to joint symptoms and rash
66
qualities of viral anthropathies
usually symmetrical affect wrists, knees, hands, feet, often accompanies by rash and/or fever

microbiology 3 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions