Viral Derm Treatment Flashcards Preview

Rheum/Musculoskeletal/Derm Week 3 > Viral Derm Treatment > Flashcards

Flashcards in Viral Derm Treatment Deck (17):
1

What drugs are available to treat the Pox virus family?

Cidofovir

2

What drugs are available to treat Varicella zoster?

-valacyclovir and acyclovir

-famciclovir (metabolized to active product, penciclovir)

 

3

What drugs are available to treat Varicella chicken pox?

-valacyclovir 

-acyclovir

4

What drugs are available to treat HHV-6?

-cidofovir

-foscarnet

-valganciclovir and ganciclovir

 

5

What drugs are available to treat HHV-7?

Cidofovir

6

What drugs are available to treat HHV-8?

-cidofovir

-famciclovir (metabolized to active product, penciclovir)- for recurrent herpes labialis 

-ganciclovir

-valacyclovir only 

7

How do DNA viruses replicate?

1) attachment

2) Uncoating and transfer of viral DNA to hsot nucleus

3) protein synthesis

4) budding and release

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8

How do acyclovir, famciclovir, and ganciclovir work?

competively inhibit viral DNA polymerase; competes with dexoygunaoisine triphosphate for incorporation into viral DNA 

 

9

How does foscarnet work?

selectively inhibits viral-specific DNA polymerases and reverse transcriptases at pyrophosphate-binding sites to block chain elongation

10

How does cidofovir work?

competitively inhibits viral DNA polymerase by competing with deoxycytosine triphosphate for incorporation into viral DNA 

11

Note about antivirals

Some drugs require sequential phosphorylation to the triphosphate form (active product). Thus, kinase deficient viral strains are inherently resistant to these agents. By contrast, cidofovir and foscarnet retain activity in such conditions because they act in a different manner 

12

How are these antivirals eliminated?

Renal, dose adjustment needed 

13

Another thing to note about antivirals, is that, similar to penicillins and select cephalosporins, there is the issue of cross-reactivity in some of these drugs with hypersensitivity due to similar structure (and thus should not be looked to as alternatives following reaction to one). What are these?

-acyclovir and valacyclovir

-famciclovir

-ganciclovir and valganciclovir 

14

AEs of acyclovir?

neurotoxic and seizures

15

AEs of cidofovir?

nephrotoxic (patients should receive probenecid and hydration with normal saline concurrently)

16

AEs of famciclovir?

None 

17

AEs of ganciclovir?

pancytopenia and teratogenic