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Microbiology > Viral Genomics > Flashcards

Viral Genomics Flashcards

1
Q

Baltimore’s division of viruses into classes is based on?

A
  1. Genome type
  2. Mode of replication
  3. Transcription
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2
Q

List the seven classes of Baltimore’s classification and give examples of viruses that belong in those categories

A

dsDNA genome eg Herpes and pox viruses

ssDNA genome eg Chicken anemia virus

dsRNA genome eg Reovirus

ssRNA genome +ve sense eg poliovirus

ssRNA genome -ve sense eg influenza and rabies viruses

ssRNA genome 🔄DNA intermediate eg retrovirus

dsDNA 🔄RNA intermediate eg Hepatitis B virus

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3
Q

What are class 1 viruses❓

How do they replicate❓

Give examples.

A

dsDNA viruses

⬇️transcription
mRNA
⬇️translation
Proteins

Herpes virus
Pox virus

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4
Q

What are class 2 viruses❓

How do they replicate❓

Give examples.

A

ssDNA viruses

dsDNA intermediate
⬇️transcription
mRNA 
⬇️translation 
Protein

Chicken anaemia virus

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5
Q

What are class 3 viruses❓

How do they replicate❓

Give examples.

A

dsRNA

⬇️RNA dependent RNA polymerase

Complementary +strand (used as mRNA)

⬇️translation

Proteins

Reovirus

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6
Q

I’m virology, what does a +ve sense mean❓

A

mRNA is said to be plus(+) configuration

It’s complement is said to be the -ve configuration

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7
Q

What are class 4 viruses❓

How do they replicate❓

Give examples.

A

ssRNA +ve sense

(serve as mRNA)
⬇️translation
Proteins

Poliovirus

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8
Q

What are class 5 viruses❓

How do they replicate❓

Give examples.

A

ssRNA -ve sense

⬇️RNA dependent RNA polymerase

Complementary +strand (used as mRNA)

⬇️translation

Proteins

Influenza virus
Rabies virus

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9
Q

What are class 6 viruses❓

How do they replicate❓

Give examples.

A

ssRNA genome 🔄DNA intermediate

ssRNA
⬇️Reverse transcriptase
DNA

eg retrovirus

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10
Q

What are class 7 viruses❓

How do they replicate❓

Give examples.

A

dsDNA 🔄RNA intermediate

Requires reverse transcriptase

eg Hepatitis B virus

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11
Q

What classes of RNA viruses have RNA dependent RNA polymerase❓

A

Class III, IV and V

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12
Q

List examples of +ve sense RNA viruses❓

A

Picornaviridae
Togaviridae
Flaviviridae
Retroviridae

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13
Q

List examples of -ve sense RNA viruses❓

A 
Paramyxoviridae
Rhabdoviridae
Orthomyxoviridae
Filoviridae 
Bunyaviridae
Reoviridae
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14
Q

List examples of dsDNA viruses

A 
Adenoviridae
Herpesviridae
Poxviridae
Papovaviridae
Hepadnaviridae
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15
Q

List examples of ssDNA viruses

A

Parvoviridae

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Microbiology (11 decks)

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