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Flashcards in Viral Hepatitis Deck (4)
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1
Q

List the mode of transmission for each type of viral hepatitis.

A

A: faecal-oral

B: birth>blood>sex

C: blood>birth=sex

D: blood>birth=sex

E: faecal-oral

2
Q

Which viral hepatitis subtypes are acute and which are chronic?

A

A: Acute only

B: Acute + chronic

C: Acute + chronic

D: Acute + chronic

E: Acute only

*B and C most dangerous

3
Q

Summarise the management for viral hepatitis.

A
  • 15-45% clear hep C without treatment
  • Direct acting antivirals
  • NSAID, opiod, anti-emetic, cream for itch
  • Hep A usually self-limiting; give supportive therapy
  • Hep B peginterferon alpha or nucleoside reverse transcriptase inhibitors (tenofovir/entefovir)
  • Hep C sofosbuvir, ledipasvir, grazoprevir (directly acting antivirals)
  • Hep D most need transplant in the end
  • Hep E ribovarin
  • Only types A and C are curable
4
Q

Summarise the investigations for viral hepatitis.

A
  • In acute disease- ALT and AST are usually >1000 (ALT > AST typically)
  • In chronic disease- ALT and AST are only mildly elevated (<100IU/l)
  • Hep A elevated IgM, not infective during jaundice. IgM means acute, IgG means chronic
  • Hep B anti HBe means exposure to live virus, anti HBs is given in vaccines. Can be chronic, often sub-clinical. Core IgM acute
  • HCV antibody test and RNA test