Viral Hepatitis

Question 1

Why is Hep G probably not actually a hepatitis virus

Answer 1

becuase the people who have it are usually co-infected with b or c, so the symptoms are from them

Question 2

HEP G
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 2

RNA
Enveloped
SS + = class IV
Flaviviridae

Question 3

Hep A
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 3

RNA
not enveloped
SS+RNA = class IV
Picornaviridae

Question 4

Hep B
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 4

dsDNA = class VII
enveloped
hepadnaviridae

Question 5

Hep C
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 5

+ ssRNA = class IV
Enveloped
Flaviviridae

Question 6

Hep D
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 6

• ssRNA = group V
  envelope
  Deltavirus

Question 7

Hep E
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 7

+ ssRNA = group IV
not enveloped
used to be Caliciviridae

Question 8

Which two hep viruses are acute only?

Why?

Answer 8

A and E

they are not enveloped, so they die easier

Question 9

Hep A route of infection

Answer 9

fecal oral - usually pools. use chlorine to help.

Question 10

You have jaundice from hep A, how long have you had the virus?

Answer 10

10 days

It already replicated in you liver a lot. It survives ph as low as 1!

Question 11

intensifying fever, fatigue, nausea, abdominal pain, dark urine, jaundice. What might that be?

Answer 11

Hep A. 99% recovery. the other 1% have an 80% of needing to buy a coffin

Question 12

(hep A) Viral load goes up, but it’s not cytotoxic, what goes up afterwords that leads to tissue damage?

Answer 12

the frickin cytotoxic t cells killin’ our liver

Question 13

What antibody is elevated acutely in hep a?

Answer 13

IgM

Question 14

What antibody is elevated to prevent future hep A infection

Answer 14

IgG

It’s also elevated after being immunized against hep A

Question 15

Symptoms of Hep E

Answer 15

same as A, but a little more severe

Question 16

Some young lass gets Hep E. Why do you care?

Answer 16

Because it’s real bad if she’s gets knocked up. High mortality in pregnant women.

Question 17

Hep B has a virulence factor that is devious. What’s that?

Answer 17

It makes two non-infectious particles that might soak up some of the immune response, giving it a higher chance of success

Question 18

Hep B infects cell that express what receptors?

Answer 18

trasferrin receptor
asialoglycoprotein receptor
annexin V protein

HBsAg binds to those, presumably (hep B surface antigen)

Question 19

What antigens are present in HBV

Answer 19

surface - HBsAg - indicates hep b infection
core - HBcAg
e - HBeAg - indicates viral replication and therefore high transmissibility

Question 20

Treatment for Hep C

Answer 20

interferon a

there are others that we don’t have to know

Question 21

Yellow Fever virus
RNA or DNA
Enveloped?
Class? (1-6)
Family?

Answer 21

RNA
icosahedral capsid, enveloped
SS + = class IV
Flaviviridae (same as hep C)

Question 22

How do you get yellow fever

Answer 22

Aedes mosquito

Question 23

symptoms of yellow fever

Answer 23

real bad flu, loss of liver, kidney and heart function, shock. 50% death.

Question 24

treatment for yellow fever

Answer 24

supportive, vaccination

Question 25

findings in liver biopsy in yellow fever

Answer 25

eosinophilic globules (councilman bodies - same as found in other toxic and viral hepatitis)

Question 26

how does HEPC enter hepatocytes

Answer 26

enter the hepatocytes that express CD81 by binding lipoprotein receptor