Virology

Question 1

Flaviviridae

Answer 1

West Nile Virus
Yellow Fever Virus
Dengue Virus
Zika Virus

Question 2

Tulip Breaking Virus

Answer 2

Potyviridae

Question 3

non-enveloped viruses

Answer 3

picarnoviridae
ds DNA
ss DNA
ds RNA
papillomaviridae

Question 4

Ebola nucleocapsid proteins

Answer 4

VP24
VP30
VP35

Question 5

Poliovirus capsid proteins

Answer 5

VP1
VP2
VP3
VP4
cleaved by 3CD to form 5S protamer
peptide P1

Question 6

helical symmetry nucleocapsids

Answer 6

measles
TMV- tobacco mosaic virus
TBV - tulip breaking virus
Ebola
VSV - vesiculus somatitis virus

Question 7

poliovirus entry

Answer 7

when poliovirus binds with the PVR receptor on the host cell membrane
hydrophobic n-terminus of VP1 protein inserts itself onto the cell membrane and VP4 creates a channel for the positive sense RNA genome to go through
VP4 - is buried

Question 8

polyhedral symmetry capsids

Answer 8

poliovirus
simian 40

Question 9

HIV-1 receptors and co-receptors

Answer 9

CD4 - main
CCR5 - co
CXCR4 - co
co-receptors are called -chemokine receptors

Question 10

Poliovirus receptor

Answer 10

PVR

Question 11

Adenoviruses 2 and 5 receptors

Answer 11

CAR
Integrin

Question 12

Murine Leukemia virus

Answer 12

cationic amino acid transporter

Question 13

Human Corona Virus

Answer 13

Amino-peptidase N

Question 14

Measles virus

Answer 14

CD46

Question 15

Some Rhinovirus

Answer 15

LDL-receptor

Question 16

gp1 protein in which envelope

Answer 16

ebola

Question 17

L protein

Answer 17

ebola rna dependent rna polymerase - viral protein

Question 18

ebola outbreak 3 cities

Answer 18

guinea
liberia
sierra leonea
countries in africa

Question 19

what does gapped ds dna also contain

Answer 19

proteins and pieces of RNA
these can be called as remnants of RNA genome and also a protein remains attached to the genome

Question 20

what can hepatitis B cause

Answer 20

liver damage- sexual contact

Question 21

rotavirus symptomps

Answer 21

first 5 years of life
gastroenteritis -infant mortality
dehydration main contributor to mortality
fever,abdominal pain diarreha

Question 22

vertice
face
edge

Answer 22

5 tail to tail
3 head to head
2 head to head

Question 23

which virus can be defined as Norwalk virus

Answer 23

quasiequivalent
also norwalk virus - non-enveloped - calicirusviridae - winter vomiting

Question 24

which sugar is sialic acid always linked to - host cell receptor

Answer 24

galactose

Question 25

what part of what gets cleaved by who in Ebola virus so it can be released from the late endosome?

Answer 25

CHO part of GP1 in Ebola envelope glycoprotein gets cleaved by cathepsins so it can interact with NPC-1 (cholesterol transporter) and get released to the cytoplasm

Question 26

difference between gp1 and gp2 in ebola

Answer 26

gp1 - binding gp2 - fusion

Question 27

west nile virus which city and which city

Answer 27

new york and israel

Question 28

after viremia what happened

Answer 28

skin rashes - hosts response to viral replications

Question 29

secondary viremia

Answer 29

delayed in virions in the blood it means transmitting to other parts

Question 30

early rash severe rash

Answer 30

papules ulcer

Question 31

sex workers in which cities

Answer 31

Zaire and Rwanda

Question 32

proviral DNA

Answer 32

viral DNA that has been already integrated to the cell genome

Question 33

where did these 4 spillover events happend to humans

Answer 33

Kinshosa (Zaire)

Question 34

where Korv a and b both present

Answer 34

koalas in LA

Question 35

how does cART work

Answer 35

it blocks the activity of viral enzymes

Question 36

gapped ds DNA

Answer 36

viral DNA dep pol filld the gaps - there are also proteins and RNA pieces and then host dna dep does the transcription

Question 37

PIC

Answer 37

gets formed in the cytoplasm after the reverse transcription is done- contains viral enzymes integrase etc and goes to the nucleus after the insertion to host genome is done it ceases to exist

Question 38

Ebola enterance to the host cell

Answer 38

fusion happens at the late endosome membrane - NPC-1 - cathepsins cut the galactose moleules - CHO part of GP1 to allow reaction with NPC-1

Question 39

gp120 and gp41 in HIV

Answer 39

gp 120 - SU - vp that interacts with the host receptors gp 41 - TM - fusion protein

Question 40

camerooon

Answer 40

little n, o , p group cases