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MICROBIOLOGY & PARASITOLOGY > Virology > Flashcards

Virology Flashcards

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1
Q

All DNA viruses are icosahedral, except _________

A

Poxvirus

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2
Q

All RNA viruses have helical symmetry, except _________

A

Rhabdovirus

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3
Q

All enveloped viruses get their envelope from plasma membrane, except __________ (nuclear membrane)

A

Herpesvirus

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4
Q

Naked DNA viruses

A

Papillomavirus
Adenovirus
Polyomavirus
Parvovirus

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5
Q

Naked RNA viruses

A

Calicivirus
Picornavirus
Reovirus
Hepevirus

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6
Q

Viruses that are considered as DNA
viruses

A

Hepadnaviridae
Herpesviridae
Adenoviridae
Poxviridae
Parvoviridae
Polyomaviridae
Papillomaviridae

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7
Q

All DNA viruses have double
stranded DNA except

A

Parvovirus

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8
Q

All DNA viruses have linear DNA
except

A

Papillomaviridae
Polyomaviridae
Hepadnaviridae

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9
Q

All DNA viruses are icosahedral
except

A

Poxvirus

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10
Q

All DNA viruses replicate in the
nucleus except

A

Poxvirus

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11
Q

Single stranded DNA virus that can
cause aplastic crisis in patients
with sickle cell anemia

A

Parvovirus

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12
Q

A 5-year-old male comes in the ER
due to rash. Upon inspection, it was
noted that he has bright red
macules on his cheeks and a lacy
reticulated erythema over the
extremities. No other symptoms
noted. What is the likely diagnosis?

A

Erythema infectiosum
(Fifth disease)

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13
Q

Histopathologic finding in patients
infected with adenovirus

A

Cowdry type B intranuclear
inclusions

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14
Q

Double stranded naked DNA virus
that can cause hemorrhagic
cystitis. It is the only virus with
fibers

A

Adenovirus

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15
Q

Most common viral STD
worldwide

A

Human Papilloma Virus

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16
Q

Functions of genes E6 and E7 of
HPV virus

A

E6 inhibits p53
E7 inhibits Rb

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17
Q

Type of HPV strain associated with
cervical cancer

A

HPV 16,18,31,33

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18
Q

Type of HPV strain associated with
condyloma acuminata

A

HPV 6,11

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19
Q

Type of HPV strains present in
Gardasil vaccine

A

Quadrivalent vaccine that has
types 6, 11, 16, 18

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20
Q

Virus that can cause hemorrhagic
cystitis in patients with kidney
transplant

A

Bk Polyoma Virus

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21
Q

Site of latency of HSV-1

A

Trigeminal ganglia

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22
Q

Site of latency of HSV -2

A

Lumbosacral ganglia

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23
Q

Most common cause of sporadic
encephalitis

A

Herpes simplex virus type 1

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24
Q

A complication of VZV that involves
the geniculate region causing facial
paralysis

A

Ramsay-Hunt Syndrome

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25
28-year-old pregnant woman comes to the clinic because of painful vesicular lesions that have appeared in her genitalia. A positive result on which diagnostic test would mean that her baby is at risk for congenital anomalies? Positive result?
Tzanck smear; Multinucleated giant cells
26
A 10-year-old male presents with vesicular centrifugal rash described as dewdrop on a rose petal
Varicella
27
Cytomegalovirus, the most common viral cause of congenital abnormalities has a pathognomonic histopathologic finding which is ____
Owl’s eye nuclear inclusions
28
Treatment of choice for CMV.
Ganciclovir
29
Atypical cells in Infectious Mononucleosis are called ______
Downey cells
30
Malignancies associated with Epstein-Barr Virus
Burkitt lymphoma B-cell lymphoma Nasopharyngeal carcinoma Hairy leukoplakia CNS lymphoma
31
Erythematous papules on soft palate and base of the uvula seen on patients infected with HHV-6 virus is called
Nagayama spots
32
HHV-8 causes what kind of malignancy
Kaposi sarcoma
33
A 6-year-old male was brought to the clinic due to papular skin lesion with umbilicated center. On histopathology there was presence of intracytoplasmic eosinophilic inclusions. What is your diagnosis?
Molluscum Contagiosum (Inclusions are called as Henderson-Paterson bodies)
34
Only DNA virus that produces DNA by reverse transcription with mRNA as template
Hepatitis B virus
35
Most specific marker for diagnosis of acute HBV infection because it persists during the window period
IgM anti-HBcAg
36
Presence of which serologic marker indicates that the patient is cured of hepatitis B
Anti-HBsAg
37
Serologic marker of Hepatitis B that tells us the patient is very infective
HBeAg
38
1st vaccine to prevent cancer
Hepatitis B virus vaccine
39
All viruses are haploid except
Retroviruses
40
All RNA viruses have single stranded RNA except
Reoviruses
41
All RNA viruses replicate in the cytoplasm except
Influenza and Retrovirus
42
Virus that replicates in motor neurons in anterior horn of spinal cord causing paralysis
Single stranded naked RNA virus (Poliovirus)
43
Route of administration for Polio Sabin vaccine
Oral
44
Most common viral cause of myocarditis and pericarditis
Coxsackie virus
45
A 8 year old male came to the ER due to high grade fever, sore throat and odynophagia. Tender vesicles were noted in the oropharynx. What is the most likely etiology if you suspect this to be a case of Herpangina
Coxsackie A virus
46
Why are rhinoviruses not known to cause gastroenteritis?
They are acid-labile thus killed by gastric acid
47
Most common cause of common colds
Single stranded naked RNA virus (Rhinovirus)
48
Hepatitis virus that has high mortality in pregnant women
Hepatitis E
49
Types of Hepatitis virus that can be transmitted thru fecaloral route
Hepatitis A Hepatitis E
50
Most common cause of viral diarrhea in adults
Norwalk virus
51
Most common cause of childhood diarrhea
Double stranded naked RNA virus (Rotavirus)
52
Vaccine for Rotavirus can be given until what age?
32 weeks
53
Part of Influenza virus that is responsible for binding to cell surface receptor
Hemagglutinin
54
Part of Influenza virus that cleaves neuraminic acid to release progeny virus from the infected cell
Neuraminidase
55
The process where major changes based on reassortment of segments of the genome RNA happens that may lead to new pandemics
Antigenic shift
56
Drug of choice for treatment of Influenza
Oseltamivir or Zanamivir
57
A 6-year-old male patient was brought to you due to pneumonia caused by Staph aureus. Upon further interview, child was noted to have a viral infection 2 weeks ago. What viral infection did the child have?
Measles
58
What do you call the multinucleated giant cells seen in patients infected with measles
Warthin-Finkeldey bodies
59
Bright red lesions with a white, central dot in buccal mucosa seen in Measles is called
Koplik spots
60
Most common complication of mumps
Aseptic meningitis
61
Most important cause of pneumonia and bronchiolitis in infants. It has fusion protein that forms multinucleated giant cells.
Respiratory Syncytial Virus
62
A 3-year-old child was brought to the clinic due to cough associated with inspiratory stridor. Xray showed steeple sign. What is your diagnosis?
Laryngotracheobronchitis (Croup)
63
Inclusion body associated with Rabies Virus
Negri body
64
A bullet shaped enveloped single stranded RNA virus that is transmitted by animal bite and moves by retrograde axonal transport to CNS. What is this virus?
Rabies virus
65
What structure of the Coronavirus is important for host attachment and penetration
S protein
66
Coronavirus binds to which receptor of the lungs?
ACE-2 receptor
67
Characteristic laboratory finding in patients with Dengue
Increased hematocrit count Leukopenia Thrombocytopenia
68
The most common etiologic agent of post-transfusion hepatitis is
Hepatitis C
69
Congenital Rubella syndrome includes:
Cataracts Sensorineural deafness Mental retardation Patent Ductus Arteriosus Blueberry muffin baby
70
Gold standard test for diagnosing HIV that detects specific protein of the virus
Western blot analysis
71
A laboratory method used to detect specific DNA molecules
Southern blot analysis
72
HIV gene that codes for the reverse transcriptase which transcribes RNA genome into DNA
pol gene
73
The protein present in HIV that mediates the fusion of the viral envelope with the cell membrane is _______.
gp41
74
The protein present in HIV that interacts with the CD4 receptor
p24
75
AIDS is diagnosed when the CD4 count is less than __________
200
76
Most common cause of epidemic viral encephalitis?
Japanese B virus

MICROBIOLOGY & PARASITOLOGY (5 decks)

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