Virology

Question 1

What do you call the skin lesion caused by a poxvirus described as flesh-colored dome lesions with central dimple?

Answer 1

Molluscum contagiosum

Question 2

What is the largest DNA virus?

Answer 2

Poxvirus

Question 3

What is the smallest DNA virus?

Answer 3

Parvovirus

Question 4

All DNA viruses are double stranded except __________.

Answer 4

Parvovirus (single stranded)

Question 5

All DNA viruses are icosahedral except ________.

Answer 5

Poxvirus (complex)

Question 6

All DNA viruses replicate in the _______ except poxvirus.

Answer 6

nucleus

Question 7

True or False:

EBV is a herpesvirus.

Answer 7

True

Question 8

True or False:

Infectious mononucleosis is caused by CMV that is Monospot test positive.

Answer 8

False

EBV = (+) Monospot test

• heterophile antibodies detected by agglutination of sheep or horse RBCs

Question 9

True or False:

Tzanck smear is the test of choice for HSV identification.

Answer 9

False

PCR is the test of choice.

Tzanck test is an office procedure usually done due to its convenience.

Question 10

True or False:

EBV is latent in mononuclear cells.

Answer 10

False

EBV is latent in B cells.

CMV is latent in mononuclear cells (lymphocytes).

Question 11

What is the virus that has reverse transcriptase other than a retrovirus?

Answer 11

HBV or Hepadnavirus

Question 12

What virus causes “common cold” and SARS?

Answer 12

Coronavirus

Question 13

True or False:

All picornaviruses are enteroviruses.

Answer 13

False

Picornavirus: Poliovirus, Echovirus, Coxsackievirus, HAV and Rhinovirus

Enterovirus: Poliovirus, Echovirus, Coxsackievirus, and HAV

Question 14

What causes infantile gastroenteritis?

Answer 14

Rotavirus

Question 15

Genetic shift / antigenic shift causes _________.

Genetic drift causes _________.

Answer 15

Genetic shift = pandemics

Genetic drift = epidemics

Question 16

The 3 C’s of measles are:

Answer 16

Cough
Coryza
Conjunctivitis

Question 17

What disease is caused by a paramyxovirus with symptoms of parotitis, orchitis, and aseptic meningitis?

Answer 17

Mumps

Question 18

What monoclonal antibody against F protein prevents pneumonia caused by RSV (paramyxovirus) infection in premature infants?

Answer 18

Palivizumab

Question 19

True or False:

Negri bodies are characteristic intranuclear inclusions in neurons infected by rabies virus commonly found in Purkinje cells of cerebellum.

Answer 19

False

Negri bodies are cytoplasmic inclusions.

Question 20

True or False:

All hepatitis viruses are RNA viruses except HBV.

Answer 20

True

Question 21

What antigenic determinant in HBV indicates active viral replication and therefore high transmissibility?

Answer 21

HBeAg

Question 22

True or False:

Anti-HBs indicates low transmissibility of HBV infection.

Answer 22

False

Anti-HBs is an antibody to HBsAg which indicates immunity to hepatitis B.

Anti-HBe is an antibody to e antigen which indicates low transmissibility.

Question 23

What is the best test to detect active hepatitis A?

Answer 23

Anti-HAV (IgM)

Question 24

What antibody indicates prior HAV infection and/or prior vaccination and protects against reinfection?

Answer 24

Anti-HAV (IgG)

Question 25

What antibody is present during the window period of HBV infection?

Answer 25

Anti-HBc (IgM)

Question 26

AIDS diagnosis: ______ CD4+ cell/mm3 (normal: 500-1500) HIV positive with AIDS-defining condition (e.g., PCP) or CD4/CD8 ratio

Answer 26

Less than or equal to 200

Question 27

CD4

Answer 27

Pneumocystis jirovecii, Cryptosporidium (

Question 28

This influenza virus undergoes both antigenic drift & shift and is the most common cause of epidemics and pandemics.

Answer 28

Influenza A

Question 29

This influenza undergoes antigenic drift and causes localized outbreaks.

Answer 29

Influenza B

Question 30

What gene of the retroviridae has the enzymes integrase & reverse transcriptase?

Answer 30

pol gene gag = p24 env = glycoprotein 120

Question 31

This virus is associated with herpangina and hand-foot-mouth disease.

Answer 31

Coxsackie A

Question 32

Human Papilloma viruses: Plantar warts = HPV type ___ and ___ Anogenital warts = HPV type ___ and ___ CIN = HPV type ___ and ___

Answer 32

Human Papilloma viruses: Plantar warts = HPV type 1 and 4 Anogenital warts = HPV type 6 and 11 CIN = HPV type 16 and 18