Virulence

Question 1

Virulence factors of strep mutans?

Answer 1

Glycolytic systems
- increase acidic environment

EPS / sucrose metabolism
- eps synthesised via sucrose metabolism
- helps to form dental biofilm
- contribute to resistance

Attachment mechanisms such as GTF

Ecological competitiveness at low pH

Question 2

Virulence factors of P.gingivalis?

Answer 2

Host cell tissue adherance and invasion
- via Fimbriae (short and long)

Elaboration of proteases - these are degradative enzymes
- collagenase
- fibrinolysin

Gingipains
- activate MMPss

Manipulate host defences
- biofilm
- tissue destruction

Question 3

Virulence factors of candida?

Answer 3

Hydrolytic enzymes

Phospholipase - host cell penetration

Haemolysin - hyphae invasion

Proteinase - adhesion to epithelial cells

Mycofilm production - large space biofilm creating scaffold and protective environment

Question 4

E.faecalis virulence factors?

Answer 4

Endotoxins

Adhesions

Immune evasion

Collagenases (hydrolytic enzymes)