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Virus Flashcards

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1
Q

Human papilloma virus associated diseases

A

Hpv 1 2 6 11 - benign warts

16 and 18 cervical anogenital and oropharyngeal carcinoma

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2
Q

Why is HPV oncogenic?

A

Because it has oncoproteins E6 and E7 which target p53 and pRb tumour suppressor pathways
Increased mutations and cancer

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3
Q

What is molluscum contagiosum?

A

Pox virus infection
Umbilicated flesh papules
Epidermal hyperplasia with eosinophilic intracytoplasmic inclusions

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4
Q

All DNA. Viruses are double stranded except?

A

Parvo virus which is ss

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5
Q

All dna viruses have linear genomes except

A

Polyoma
Papilloma
Hepadna partially circular dsdna

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6
Q

Name the enveloped DNA VIRUSES

A

HHP
Herpes
Hepadna Pox

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7
Q

Name the non enveloped DNA Viruses

A

Polyoma
Papilloma
Parvo
Adeno

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8
Q

All DNA Viruses get their envelope from plasma membrane while budding except

A

Herpes which gets env from nuclear membrane

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9
Q

All DNA viruses replicate in nucleus except

A

Pox virus
Which replicates in cytoplasm
Because it has its own dna dependent rna polymerase

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10
Q

Diseases of polyoma virus

A

JC VIRUS- pml in hiv or immunosuppressed

BK VIRUS- transplant patient causes nephropathy

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11
Q

Hsv -1 is latent in which ganglia

A

Trigeminal ganglia

Causes sporadic encephalitis

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12
Q

Hsv 2 is latent in which ganglia

A

Sacral ganglia because it causes herpes genitalis

Viral meningitis is more common with hsv 2 than 1

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13
Q

What causes neonatal herpes

A

Hsv 2

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14
Q

What causes herpetic whitlow on finger

A

Hsv 1

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15
Q

What causes face mouth eye herpes temporal lobe encephalitis and esophagitis
Erythema multiforme

A

Hsv 1

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16
Q

What are herpes virus 3 4 5

A

VZV 3

EBV 4

CMV 5

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17
Q

How does ebv infecf

A

Respiratory secretions kissing disease in teens
Infects B CELLS BY Binding to CD 21
T. Cell respond forming smudge cells

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18
Q

Which drug is avoided in mononucleosis

A

Amoxicillin in mononucleosis causes maculopapular rash

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19
Q

What are manifestations of cmv

A

Mononucleosis with negative monospot test in immunocompetent

Infection in immunosuppressed
Ie cmv pneumonia in transplant, 
Esophagitis
AIDS RETINITIS- hemorrhage cotton wool exudates vision loss
Congenital cmv infection
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20
Q

Where does cmv remain latent

A

In monocytes

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21
Q

What do infected cmv cells look like

A

Owl eye intranuclear inclusion

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22
Q

Features of congenital cmv infection

Study These Flashcards
A 
Hearing loss
Seizures
Petechial rash and blueberry muffin rash  
Chorioretinitis
Periventricular calcification
23
Q

How is HSV virus identified in lab

Study These Flashcards
A

For skin and genitalia—- culture
For cns—- do CSF PCR
TZANKS SMEAR—- from opened skin vesicle shows multinucleated giant cell which have intranuclear eosinophilic cowdry type A inclusion/-1 to 3 hhv

24
Q

Entry receptor for CMV

Study These Flashcards
A

Integrins ( heparan sulfate)

25
Entry receptor for PARVOVIRUS B 19
P antigen on rbc
26
Entry antigen for rabies virus
Nicotinic ACH receptor
27
Entry receptor for rhinovirus
ICAM 1
28
All RNA VIRUS replicate in cytoplasm except
Retrovirus HIV | Influenza virus
29
Disease caused by reoviruses
Rota virus causes fatal diarrhoea in children Coltivirus is an arbovirus causing colorado tick fever caused by bite of ticks
30
Name various picorna virus
PERCH POLIO Echo virus - aseptic meningitis Rhinovirus- common cold Coxsackie - aseptic meningitis hand foot mouth synd, herpangina- fever with mouth blisters, heart—/ pericarditis and myocarditis HAV - acute viral hepatitis
31
Name the genuses of hepatitis viruses
HAV PICORNA - rna HBV HEPADNA—- dna HCV - flavivirus - rna HDV DELTA VIRUS - rna
32
Diseases caused by flaviviruses
``` HCV YELLOW FEVER DENGUE ZIKA WEST NILE ENCEPHALITIS ST LOUIS ENCEPHALITIS ```
33
Diseases caused by toga viruses
CREW CHIKUN GUNYA WHICH IS A CO INFECTION WITH DENGUE Rubella Eastern and western equine encephalitis
34
Disease by paramyxovirus
Parainfluenza - croup RSV - bronchiolitis in babies Mumps measles
35
Diseases caused by filovirus
Ebola Marburg haemorrhagic fever Both are fatal
36
Name the segmented viruses
All are RNA viruses BARO bunya— hanta virus haemorrhagic- 3 segments Arena - lasss fever/ LCMV- 2 segments Reo —rota colti- 10 to 12 segments Orthomyxo- influenza - 8 segments
37
Yellow fever is transmitted by
Aedes mosquito bite transmits yellow fever virus which is a flavivirus
38
Features of yellow fever
High fever Black vomitus Jaundice and severe hepatitis
39
Features of hepatitis in yellow fevef
Mid zone hepatic necrosis Dying hepatocyte condense into eosinophillic contracted form known as councilmans bodies These are inclusion due to apoptosis and are non specific
40
Pathomechanism of rota virus
Villous destruction with atrophy Loss of potassium and reduced absorption of sodium
41
Routine vaccination of rota virus is not given in which children?
One with intusucceptiion | Scid disease
42
What is antigenic shift
Sudden severe pandemics Due to REASSORTMENT OF VIRAL GENOME SEGMENTS BTN HUMAN INFLUENZA A AND SWINE FLU A VIRUS
43
Antigenic drift
Drifts are gradual minor changes based on mutations in hemagglutinin and neuraminidase genes Causes epidemics
44
Congenital rubella
Blueberry muffin appearence due to dermal extramedullary hemopoeisis
45
A premature infant is given this drug as prophylaxis to prevent RSV PNEUMONIA
Palivizumab- monoclonal antibody against F protein of paramyxovirus- RSV VIRUS
46
Acute laryngotracheobronchitis sign on xray
Steeple sign
47
Features of croup
Acute LTB causes of parainfluenza Barking cough with inspiratory stridor and hence obstruction likely can cause pulsus paradoxus
48
Lymph node biopsy in measles
Lymphadenitis with paracortical hyperplasia Having fused lymphocytes—- warthin finked ley giant cells
49
Effects of mumps virus
Parotitis Orchitis - sterility after puberty Pancreatitis Aseptic meningitis
50
Route of transmission of rabies
Bat racoon skunk bites Dog bites if not in usa Bat caves aerosol
51
Travel of rabies virus in body
Entry into neurons by acetyl choline receptors Travels retrograde in axons using dynein motor tubules Reaches cerebellum purkinje cells and hippocampus in temporal lobe
52
What are negri bodies
Intracytoplasmic inclusions in rabies infection | Seen in purkinje cells of cerebellum and hippocampal neurons
53
What cells ebola infect
Endothelial cells hence can cause haemorrhagic shock dic and death Hepatocytes Phagocytes
54
Effects of zika
Adults - conjunctivitis fever itchy rash Pregnancy- congenital microcephaly and miscarriage Outbreaks in tropical and subtropics

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