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EXAM 5 > Virus Review > Flashcards

Virus Review Flashcards

1
Q

+ RNA

A

can be directly translated into protein

other steps for everything else

(even + RNA needs to become - RNA to replicate!)

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2
Q

enveloped viruses

A

retro (HIV, HTLV-1)

Influenza

Hep B, C, D

herpes (ALL)

Pos

RSV

Measles

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3
Q

non-enveloped viruses

A

picorna (polio, rhino, Hep A)

papova (HPV, JC, BK, MeCPV, WI, HU)

adeno

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4
Q

Retrovirus nucleic acid and site of rep

A

HIV, HTLA-1

+ RNA

nuclear replication

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5
Q

Influenza nucleic acid and site of rep

A
  • RNA, segments

nuclear replication

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6
Q

Hep B nucleic acid and site of rep

A

gap dsDNA

nuclear replication

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7
Q

Hep D nucleic acid and site of rep

A

RNA viroid

nuclear replication

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8
Q

Hep C nucleic acid and site of rep

A

+ RNA

cytoplasmic replication

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9
Q

Herpes nucleic acid and site of rep

A

dsDNA

nuclear replication

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10
Q

pox nucleic acid and site of rep

A

ds DNA

cytoplamsic replication

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11
Q

RSV nucleic acid and site of rep

A
  • RNA

cytoplasmic

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12
Q

measles nucleic acid and site of rep

A
  • RNA

cytoplasmic replication

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13
Q

mistakes in replicating genome - most? least? basis/advantage? consequences?

A

RNA viruses!

no proofreading

DNA viruses have proofreading

mutation, evolve fast, evade immune - make a ton bc a lot are unfit

drug resistance!

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14
Q

whyich virus has a unique way of massive rapid change?

A

genetic shift - influenza!! in bigs, mixing vessel for shift

drift - mutation, why new vaccine each year

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15
Q

therapeutic strategies unique to env viruses?

A

fusion - merging of 2 membranes, has to be catalyzed!

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16
Q

what can be treated with nt analogs?

A

HIV, HBV, herpes

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17
Q

which can be vaccinated against?

A

flu, HBV, chickenpox, measles

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18
Q

picornaviruses

A

polio, rhino, HAV

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19
Q

picornavirus nucleic acid and site of rep

A

+ RNA

cytoplasmic

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20
Q

papovavirus nucleic acid and site of rep

A

dsDNA

nuclear

21
Q

adenovirus nucleic acid and site of rep

A

dsDNA

nuclear

22
Q

acute viral lifestyle

A
23
Q

chronic viral lifestyle

A

chronic, HBV, HCV

24
Q

herpes lifecycle

A
25
Q

HIV lifecycle

A
26
Q

viruses with latency

A

herpes, HIV

27
Q

viruses with integration

A

HIV, HTLV

RV!

herpes don’t integrate

28
Q

viruses that change for persistence

A

HCV - immune editing, mutation –> selection

RNA virus

29
Q

nucleoside analogs

A

needs to be TriPO4 to be active

P by cell kinases

toxicity in rapidly dividing cells (not acyclovir)

30
Q

protease inhibitors

A

HIV, polio, HAV, herpes (scaffold)

used in HAV and HCV

31
Q

anitsense phosphothoirate oligont

A

CMV

32
Q

polymerase inhibitors

A

HCV

HIV (RT)

CMV (gangcyclovir)

herpes (acyclovir)

Foscarnet (IV, toxic)

33
Q

neuraminidase inhibitors

A

flue - can’t get out

NA on surface

34
Q

which viruses are assocated with malignancies

A

HIV, HTLV1

Hep B, Hep C

Herpes - EBV, KSHV

HPV

35
Q

viral dominant GOF oncogenes

A

v-onc lead to identification of human proto-oncogenes

HTLV1 - tax

EBV - LMP1, EBNA2

KSHV

36
Q

iral oncoproteins that antagonize cell tumor suppressor

A

HPV - E6/E7

basal cell will only divide when it touches basement membrane - only make viruses as top

E6 - take away p53

break E2 - make more E6, E7, cell growht not controlled

37
Q

indirect viral cause of cancer

A

HCV, HBV (necoinflammatory response)

HIV - immunosuppression

38
Q

IFN-a

A

produced by leukocytes

induced by virus infection, dsRNA

39
Q

IFN-b

A

produced by fibroblasts, epithelial cells

induced by virus infection, dsRNA

40
Q

ifn-g

A

produced by T cells, NK cells

induced by ags, IL-2, IL-12

41
Q

virus foiling acquired immune system

A

latency - no protein produced (herpes)

ag variation - change (all RNA viruses, influenza has more)

remove MHC - mess w ag presentation (herpes, HIV)

42
Q

live attenuated vaccines

A

polio, VZV, smallpox, rotavirus, measles, mumps, rubella

43
Q

killed vaccines

A

polio, hav, influenza

44
Q

subunit vaccines

A

HPV, HBV (cancer)

45
Q

enteric

A

polio, HAV,

46
Q

respiratory

A

rhinovirus, flu

47
Q

sexual transmission

A

herpes, hbv, hiv, hcv (msm)

48
Q
A

EXAM 5 (11 decks)

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