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Epidemiology > Viruses > Flashcards

Viruses Flashcards

1
Q

SMEDI

A

Porcine parvovirus 1
Protoparvovirus
Parvoviridae family
small, non enveloped, negative sense DNA
capsid, 3 viral proteins: VP-1,2 (main neutralising antibodies),3
Uses cellular polymerase enzyme, so it will replicate in dividing cells

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2
Q

SMEDI biotypes

A

5 biotypes: 1. NADL-2: apathogenic, 2. Classical PPV-1: SMEDI, 3. Kresse strain: dermatitis, death of immunocompetent fetus, 4. Strain with skin symptoms, 5.Coinfections with PCV-2: PMWS, PRDC

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3
Q

Dog parvo

A

Canine Parvo Virus -2 (Pathogenic Serotype) Protoparvovirus
Parvoviridae family
CPV-1: original non pathogenic viruses of dogs
high resistance: month long survival → bleach disinfection!
In cats: in 10% feline panleukopenia is caused by CPV! (only A subtypes)

CPV2a, CPV2b, CPV2c

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4
Q

Feline panleukopenia / Feline distemper/ Feline parvo

A

Parvoviridae family
Carnivore Protoparvovirus (1)
FPLV- Feline Panleukopenia Virus

CPV-2a,b,c can also infect felidae

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5
Q

MEV

A

Mink enteritis disease virus (protoparvo, parvoviridae)
Patho, CS: like dog/ cat parvo
Vaccination: inactivated from 2 months of age, together with pseudomonas and botulism

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6
Q

ADV

A

Aleutian mink disease virus : parvovirus (amdoparvovirus)
ADV: aleutian mink disease virus (kills young animals as a result of massive humoral response to both the capsid and non-capsid viral proteins) Amdoparvovirus Parvoviridae
Aleutian genotype is more susceptible-defect in antigen presentation
young: intertitial pneumonia
older: hypergammaglobulinemia, glomerulonephritis
PLASMACYTOSIS
No virus neutralizing antibodies → Immuncomplexes → Type III hypersensitivity

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7
Q

Derzsy disease

A

Goose parvovirus , goose and muscovy duck are susceptible

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8
Q

Duck parvovirus- SBDS

A

Short beak and dwarfism syndrome
pathomechanism, dx, px like Derzsy
CS, patho different
only barbari and muscovy duck Geese isnt susceptible

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9
Q

PMWS

A

PCV-2, circovirus
post weaning multisystemic wasting syndrome

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10
Q

PDNS

A

porcine dermatitis nephropathy syndrome
PCV-2 but it may develop without PCV !!

high pcv ab titers –> type III hypersensitivity –> immunocomplex depositions in kidney, skin, blood vessels

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11
Q

PBFDV
PiCV
GoCV

A

PBFDV: psittaci beak and feather disease virus, young under 3 years
PiCV: pigeon Circovirus, 1-12 months
GoCV: goose circovirus, from 1week, coinfection with riemerella anatipestifer.

Immunosuppression, secondary bacterial infections
all circovirus genus, circoviridae family

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12
Q

CAV

A

chicken infectious anaemia
anelloviridae family, gyrovirus genus
it was a circovirus, but the replication cycle is a little bit different. First cell infected is the T progenitor cells and the myeloid progenitor cells.
Destroys red a white blood cells
anaemia and immunosuppression

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13
Q

Papillomatoses

A

papillomaviridae: linear dsDNA, non-enveloped, survives in the environment for months
Autovaccines are available
BoPV 1-6: bovine papillomatoses, delta (1,2), epsilon (5), xipapillomavirus (3,4,6)
1,2: infects horse, 1,2,3: skin lesions, 4: intestine 5,6: skin of udder. species specific immunity
EPV-2
Horse sarcoid: BoPV-1,2
dog, cat papillomatoses
human: >50 types

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14
Q

Horse sarcoid

A

BoPV 1,2

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15
Q

hemorrhagic nephritis and enteritis of geese

A

GHPV: goose hemorrhagic polyomavirus, polyomavirus genus, polyomaviridae
goose 4-10 w, muscovy duck (sero+, , symptomless, high titre)

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16
Q

pneumoenteritis of calves

A

1-4 months
Bovine mastadenovirus A-C, Bovine atadenovirus D-F
Hemorrhagic enteritis (C= BAdV-10)

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17
Q

pneumoenteritis of sheep

A

Ovine mastadenovirus A-c, Ovine atadenovirus D, bovine adenovirus

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18
Q

Rubarth disease/ infectious hepatitis

A

blue eye disease
dogs with vomiting, diarrhoea, bleeding, icterus
CAdV-1 Mastadenovirus, Adenoviridae
1-3 m
peracute/ acute/ extended
Type III hs, DIC–> IC depots
Cowdry A inclusion bodies

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19
Q

Infectious laryngotracheitis of dogs

A

CAdV-2

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20
Q

Inclusion body hepatitis

A

FAdV-1,7,8 Aviadenovirus

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21
Q

Hepatitis hydropericardium syndrome in goose

A

FAdV-4 Aviadenovirus

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22
Q

Turkey hemorrhagic encephalitis

A

TAdV-3 Siadenovirus

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23
Q

Marble spleen disease pheasant

A

TAdV-3 Siadenovirus

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24
Q

Splenomegaly in chicken

A

TAdV-3 Siadenovirus

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25
Q

EDSV

A

DAdV-1 Atadenovirus

26
Q

EDSV goose

A

DAdV-1 Atadenovirus

27
Q

Alphaherpesvirinae

A

Alphaherpesvirinae subfamily - short replication (fast), latency in neural
tissue
Simplexvirus - BoHV-2
Varicellovirus - BoHV-1, -5 (IBR), EHV-1, 3-4, 8-9, SuHV-1 (Aujeszky), CaHV-1, FeHV-1
Mardivirus - GaHV-2, -3 (Marek 1, 2), MeHV-1 (turkey herpes 1) CoHV-1
Iltovirus - GaHV-1 (ILTV), PsHV-1 (Pacheco’s disease)

28
Q

Betaherpesvirinae

A

Betaherpesvirinae subfamily - longer replication time, latency in diff. tissues,
freq in salivary gl.
Cytomegalovirus - HHV-5
Muromegalovirus - MCMV-1, -2
Proboscivirus - ElHV-1 (elephant herpes)
Roseolovirus – HHV-6,-7
Unassigned - SuHV-2 (inclusion body rhinitis), CvHV-2, TuHV-1

29
Q

Gammaherpesvirinae

A

Gammaherpesvirinae subfamily - quite long replication time,
lymphoproliferating ➔ tumor
Lymphocryptovirus - HHV-4, (Epstein-Barr virus)
Rhadinovirus - BoHV-4 (Movar herpesvirus)
Macavirus - OvHV-2 (malignant catarrh), AlHV-1, -2, BHV-6, SuHV-3, -4, -5
Percavirus - EHV-2, -5
Species unassigned to subfamilies and genera (several): AnHV-1 (duck plaque)

30
Q

IBR

A

alphaherpesvirus, varicellovirus, BoHV-1(5)

31
Q

Bovine Herpes Mammilitis

A

BoHV-2, simplexvirus, alphaherpes

32
Q

Inclusion body rhinitis , swine

A

SuHV-2 , unassigned, betaherpesvirus

33
Q

Malignant catarrhal fever

A

Gammaherpes,Macavirus: AlHV-1, OvHV-2
cattle gets it from sheep, they are asymptomatic
cattle does not infect other cattle
fast spread tho
no vax no tx

34
Q

Aujeszky

A

alphaherpes, varicellovirus: SuHV-1
all mammals except humans, die too fast to shed
pigs- all ages
Mad itch- cattle, goat, sheep

35
Q

Equine rhinopneumonitis/ epizootic abortion

A

EHV-1 : respiratory signs, abortion, CNS signs
EHV-4: respiratory signs, (abortion)
75% DNA homology–> cross-reaction, but no cross-protection!
abortion storms-30-40%, sudden
vaccines are available: usually protect against respiratory forms

36
Q

EHV-2,3,5

A

EHV-2: percavirus, gammaherpes, respiratory signs, only in young horses, can be isolated from many healthy horses, so the role is unknown
EHV-3: coital exanthema, varicellovirus, alphavirus. benign venereal disease. NO abortion NO foethopathy
EHV-5: percavirus, gammaherpes , role in EMPF: equine multinodular pulmonary fibrosis, but unknown exactly

37
Q

Infectious rhinotracheitis in cat

A

FeHV-1, varicellovirus, alphaherpes, YOPI, adult: abortion
>10 w most susceptible >1 y rarely

38
Q

Canine herpes

A

CaHV-1, varicellovirus, alphaherpes
all ages <3 w most susceptible, abortion in pregnant bitches (vax)

39
Q

infectious laryngotracheitis of chickens (ILT)

A

GaHV-1 , iltovirus genus, alphaherpesvirinae
no viraemia, no germinative infection
mainly growers, adults >8-10 weeks
very contagious, fast spread

40
Q

Marek disease

A

GaHV-2,3 Mardivirus genus, Alphaherpesvirinae
two serotypes:
1. marek disease : very virulent/virulent/low virulence/avirulent
2. apathogenic, + MeHV-1 –> vaccine strain
1-2 most suceptible
neural form, visceral form
tumour formation
acute > 6 w, chronic >6 mo
virus shedding through feather follicles
no germinative infection
diff.dx. reticuloendotheliosis – diff only by lab!

41
Q

Duck plaque

A

AnHV-1 unassigned, gammaherpes?
duck, goose, swan- adults are more susceptible
“duck viral enteritis”
vax

42
Q

Pigeon herpes

A

CoHV-1, Mardivirus genus, Alphaherpesvirinae
mainly 2-6 months
adults are asymptomatic carriers
vax

43
Q

Cowpox

A

orthopox genus, chordopoxvirinae
zoonotic
hemorrhagic lesions aka black spots

44
Q

Pseudocowpox

A

no black spots as in cowpox
parapox, chordopoxvirinae
no lifelong immunity, coz it is parapox
zoonotic
Milker’s nodule

45
Q

Bovine pustular dermatitis

A

parapox, chordopoxvirinae
no lifelong immunity coz it is parapox
mouth and the skin around is affected
only cattle, 1-6 m
adult: carriers

46
Q

Lumpy skin disease

A

notifiable, not in Europe
capripox, chordopoxvirinae
mechanical vector: mosquito
wet season: generalised form, frequent
dry season: localised form, mild

47
Q

Contagious pustular dermatitis of sheep and goat
ORF, ectyma contagiosa

A

Parapox
notifiable
zoonotic–> use gloves!

48
Q

Swine pox

A

suipox

49
Q

Sheep and goat pox

A

capripox
two different viruses, both infect both sheep and goat
eradicated from europe, Us, Aus
widely distributed in Asia and Africa
lymphoma like nodules in lungs, GIT, crosses fetus

50
Q

Myxomatosis

A

notifiable
leporipox
hares arent susceptible but cotton tailed rabbits and domestic rabbit are
mosquitoes!
2 types: south american and californian (higher V)
forms
typical
nodular
atypical

51
Q

Fowl pox

A

Avipox

52
Q

ASF

A

asfivirus g, asfarviridae, linear dsDNA
hemorrhages everywhere, all ages, always abortus
soft ticks!
no vax

53
Q

Porcine polioencephalomyelitis
Teschen, Talfan

A

Teschovirus , porcine enterovirus I, picornavirales, picornaviridae
Teschen: high V, all ages
Talfan: low V, <4 m , mostly 5-8 w
Po–> GI epithelium. Enteric phase.no CS, shedding 6-8 w–> recovery OR enters bloodstream –> viraemic phase–> CNS –> neural phase

54
Q

Swine vesicular disease

A

picornaviridae , enterovirus serotype 9
vesicles
from coxaci b5

55
Q

Vesicular exanthema of swine

A

from sea mammals
calicivirus, vesivirus

56
Q

Avian encephalomyelitis

A

Tremovirus, picornaviridae
all ages
germinative infection: infected birds lay infected eggs, it does not kill embryo

57
Q

Duck hepatitis

A

Type I
Picornaviridae, Avihepatovirus, Duck hepatitis A virus
Everywhere, clinically up to 6 weeks of age, highest virulence
Incubation: 18-48 hours, every death within 1 week, up to 95%
Type II
Astroviridae, Avastrovirus, Duck astrovirus (+ssRNA, nonenveloped)
UK, Up to 6 weeks of age
Difficult to isolate, propagate’
Type III
Picornaviridae, unassigned picornavirus
30% mortality
Duck hepatitis B
Hepadnaviridae, Avihepadnav, Duck hepatitis B (circ, dsDNA, envelope)
China, older ducks and geese

58
Q

Encephalomyocarditis

A

cardiovirus, picornaviridae
rodents, swine, captive zoo animals, eg elephant

59
Q

FMD

A

aphtovirus, picornaviridae
cattle > swine> sheep , goat
notifiable, human can be infected
europe is currently free
vaccination: only endemic areas
stamping out policy
shedding from 9hpi
O, A, C, Sat 1,2,3, Asia 1

60
Q

TGE

A

Porcine Transmissible Gastroenteritis Virus (TGEV) Alphacoronavirus 1a
Coronaviridae
+ssRNA, enveloped

61
Q

Anthrax

A

Bacillus anthracis

Epidemiology (2 decks)

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