viruses and cancer

Question 1

what virus does not casue cancer

Answer 1

HIV

Question 2

of viruses HPV, retrovirus, HCV, HBV
what is direct and indirect?

Answer 2

direct= retrovirus, HPV
indirect= retrovirus, HCV, HBV, HIV

Question 3

HPV (human papillomavirus)
what kind of cancer?
how do genes E6 and E7 work to induce HPV
-function of E2

-what kind of vaccination is used?

Answer 3

cervical cancer more prevelnt in females

E6= inhibits p53 and causes loss in cell cycle regulation
E7= pRB retroblastoma mediated deregulation of cell cycle

E2= stops E6 and E7

vaccination= gardasil 9

Question 4

retrovirus 3 mechanisms
-do they carry oncogone
-how it acts on host gene

1) tranducing (animal only)
2) cis activiating (animal only)
3) trans- activity (human)

Answer 4

1) contains oncogone, replaces viral gene with oncogone. gene tranfer

2) no oncogone, activates adjacent proto-oncogone

3) no oncogone. HTLV-1 turned on.
activates via viral proteins e.g.
tax transcriptional activator= activates virus but also activates host factors in cells that drive cancer.

Question 5

what kind of cancer does hepatitis B and C casue

Answer 5

liver cancer

Question 6

viruses that cause cancer directly or indirectly

Answer 6

directly=HPV
indirectly= hepatitis virus, HIV

Question 7

viruses which are associated with what cancer
1) EBV (herpes virus)
2) HTLV-1

Answer 7

1) stomach
2) leukaemia and lymphoma