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Viruses specials Flashcards

(63 cards)

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1
Q

EBV

A

EBV gp350 binds to CD 21 (CR 2)

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2
Q

Adenovirus

A

Hexone and Pentone capsomeres- rodlike projections from Pentone based capsomeres interact with transmembrane protein members from Ig superfamily

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3
Q

Parvovirus

A

mimics Rhematoid arthritis in adults

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4
Q

Parvovirus

A

Childern: Aplastic crisis in sickle cell disease, Erythema infectiosum (Fifth disease), Hydrops fetalis, Adults: pure RBC aplasia, RA-like symptoms

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5
Q

Parvovirus

A

Attaches RBC via blood group P-antigen; adult bone marrow (BM) and fetal liver principal targets;
Replicates in BM

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6
Q

Polyoma: JC virus

A

Progressive Multifocal Leukoencephalopathy (PML) in HIV; cytoplasmic inclusions in oligodendrocytes

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7
Q

Polyoma: BK viruses

A

Transplant patients; Targets Kidney- Hemorrhagic cystitis

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8
Q

Poxvirus: Vaccinia

A

Cowpox (Milkmaid’s blisters)

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9
Q

Poxvirus

A

Molluscum contagiosum- flesh-colored dome lesions with central dimple

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10
Q

CMV

A

AIDS retinits, Transplant recipients, Blood transfusion

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11
Q

CMV

A

Require initial contact with GAG chains on host cell surface proteoglycan for entry

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12
Q

Mononucleosis-like syndromes (monospot -ve)

A

CMV, HHV-6, toxoplasmosis

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13
Q

Virion/Virion-protein binding to cell surface receptors specificities

A

1) HIV gp120 and CD4 (CCR5/CXCR4).
2) EBV gp350 and CD21 (CR2).
3) Parvovirus B19 and Erythrocyte P-antigen
4) CMV and cellular integrins
5) Rabies and nAChRs
6) Rhinovirus and ICAM-1 (CD 54)

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14
Q

Naked, double stranded, RNA, segmented

A

Reoviruses: Rotavirus and Coltivirus

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15
Q

Coltivirus

A

Colorado tick fever

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16
Q

Rotavirus

A

1 cause of fatal diarrhea in children

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17
Q

Naked, +ssRNA, nonsegmented

A

Picornaviruses (PEECoRnA: Polio, Echo, Coxsackie, Rhino, HAV), Calicivirus, Hepevirus (HEV).

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18
Q

Negative stranded RNA viruses

A

Always Bring Polymerase Or Fail to Replicate: Arenavirus, Bunyavirus, Paramyxovirus, Orthomyxovirus, Filovirus, Rhabdovirus

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19
Q

Segmented viruses (BOAR)

A

Bunyavirus, Orthomyxovirus, Arenavirus, Reovirus

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20
Q

All segmented viruses are -ssRNA viruses, except–

A

Reovirus (dsRNA)

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21
Q

All -ssRNA are linear except–ABD

A

Arenavirus, Bunyavirus, Deltavirus (HDV) are circular

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22
Q

All -ssRNA virus capsids–

A

Helical

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23
Q

All +ssRNA and dsRNA (Reovirus) capsids are–

A

Icosahedral, except Coronavirus (Helical)

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24
Q

Genetic Shift

A

Reassortment- segmented genome undergo high-frequency recombination- pandemic

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25
Genetic drift
Random mutations- epidemic
26
Picornaviruses
All are enteroviruses, except Rhinovirus
27
Congenital Rubella
Intrauterine infection- Head: microcephaly, mental retardation; Ear: Sensorineural deafness; Eye: cataract (white pupil); Heart: PDA or peripheral pulmonic stenosis
28
Rubella
Polyarthritis/Polyarthralgia in mother
29
Paramyxoviruses
Parainfuenza, Mumps, Measles, RSV
30
Paramyxoviruses
All contain surface protein F: causes respiratory epithelial to fuse and form multi-nucleated cells.
31
Palivizumab (monoclonal Ab against F protein)
prevents pneumonia in premature infants due to paramyxovirus infection (RSV)
32
Mumps- POM
Parotitis, Orchitis (infertility), aseptic Meningitis
33
Rabies
binds to nAChRs- receptor-mediated endocytosis
34
HCV
Flavivirus (unenveloped, +ssRNA, non-segmented)
35
HCV
High mortality in pregnant mothers
36
HCV
lymphoid aggregates within portal tracts and focal areas of macrovesicular steatosis
37
HBV acute infection
HBsAg+, HBeAg+, anti-HBcAg-IgM+
38
Window period
+ve anti-HBcAg-IgM: more specific marker for acute HBV
39
HBsAg+ > 3 months
increase likelihood of chronic hepatitis B
40
IgG-anti-HBc +
recovery from disease
41
HBsAg+ > 6 months
Carrier state
42
Chronic HBV (high infectivity)
HBsAg +, HBeAg +, IgG-anti-HBc +
43
Chronic HBV (Low infectivity)
HBsAg +, anti-HBeAg +, IgG-anti-HBc +
44
Recovery
anti-HBsAg +, anti-HBeAg +, IgG-anti-HBc +
45
Immunized
anti-HBsAg antibodies only
46
HBsAg
spherules and tubules 22 nm diameter of HBsAg in hepatocellular cytoplasm- finely granular, eosinophilic "ground glass" appearance of cytoplasm
47
HIV: 3 structural genes
env, gag, and pol
48
env
polyprotein product of env gene glycosylated to gp 160 and proteolytically cleaved in ER and Golgi to gp120 and gp41.
49
gp120
binds to CD4 and CXCR4 or CCR5: attachment to host T cell
50
gp41
fusion and entry
51
gag
capsid protein: p24
52
pol
reverse transcriptase, integrase, proteases
53
HIV: 6 regulatory genes
tat, rev, nef, vif, vpr, vpu
54
tat
transcriptionally activates other genes and contributes to HIV virulence
55
rev
facilitates transport of unspliced viral transcripts out of nucleus
56
nef
enhances replication by down-regulating CD4 and MHC-I expression
57
HIV-associated encephalopathy
microglial nodules and multi-nucleated giant cells
58
HIV +ve, superficial vascular proliferation, biopsy- neutrophilic inflammation
Bartonella henselae (bacillary angiomatosis)
59
HIV +ve, superficial vascular proliferation, biopsy- lymphocytic inflammation
HHV-8 (Kaposi's sarcoma)
60
Congenital CMV
Deafness, seizures, petechial rash, blueberry-muffin rash
61
Congenital syphilis
Notched teeth (Hutchinson's teeth), saddle nose, short maxilla, saber shin, CN VIII deafness, hemorrhagic rhinitis
62
Congenital HSV-2
Temporal encephalitis
63
Coxsackievirus type A
Hand-Foot-Mouth disease- vesicular rash on palms and soles; myocarditis

Microbiology (13 decks)

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