Volatiles Flashcards

(54 cards)

1
Q

What is the MAC of halothane

A

0.75

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2
Q

What is halothanes OGPC

A

224

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3
Q

Halothanes blood:gas cooefficient

A

2.4

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4
Q

What is halothanes boiling point

A

50

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5
Q

What is halothanes SVP

A

32

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6
Q

What are halothanes side effects

A

Bronchodilator
Reduced CO
Increase CBF
Hepatitis (more in adults -> necrosis)

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7
Q

How is halothane metabolised

A

20% via CYP450 to trifluoroacetic acid, chlorine, bromine

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8
Q

What type of chemical is halothane

A

Halogenated hydrocarbon
Unstable in light

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9
Q

What is the MAC of isoflurane

A

1.17

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10
Q

What is isofluranes OGPC

A

98

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11
Q

What is isofluranes blood gas coefficient

A

1.4

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12
Q

What is isofluranes boiling point

A

48

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13
Q

What is the SVP of isoflurane

A

33

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14
Q

What are isofluranes effects

A

airway irritant
reduced SVR (?coronary steal)
Best CBF profile (no increase if <1MAC)

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15
Q

What is isofluranes metabolism

A

0.2% hepatic to trifluoroacetic acid and fluorides.
CHF2 and sodalime might -> CO

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16
Q

What type of chemical is isoflurane

A

Halogenated ethyl methyl ether

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17
Q

What is enfluranes MAC

A

1.68

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18
Q

What is enfluranes OGPC

A

98

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19
Q

What is enfluranes BGPC

A

1.8

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20
Q

What is the boiling point of enflurane

A

56

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21
Q

What is the SVP of enflurane

A

23

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22
Q

What are enfluranes side effects

A

At high concentrations get a 3Hz spike in EEG similar to seizure

23
Q

What is the metabolism of enflurane

A

2% to fluorides which can cause nephropathy.
CHF2 and sodalime might -> CO

24
Q

What is sevofluranes MAC

25
What is sevofluranes OGPC
80
26
What is sevofluranes BGPC
0.7
27
What is sevofluranes boiling point
58
28
What is sevofluranes SVP
23
29
What are sevofluranes side effects
Reduced SVR
30
What is sevofluranes metabolism
3.5% via CYP2E1 Fluorides and soda lime -> compound A
31
What type of chemical is sevoflurane
Polyfluorinated isopropyl methy ether Achiral
32
How is sevo stored and why
In polyethylene napthalate with 300ppm water If stored with <100ppm water/ in glass -> lewis acids -> hydrofluoric acid
33
What is desflurane's MAC
6.6
34
What is desfluranes OGPC
29
35
What is desfluranes BGPC
0.4
36
What is desfluranes boiling point
23
37
What is desfluranes SVP
89
38
What are desfluranes side effects
Quick onsent/offset Tachycardia HTN
39
What is desfluranes metabolism
0.02% to trifluoroacetic acid CHF2 + soda lime -> CO
40
What are the TEC 6 conditions?
Heated to 39 at 2bar
41
What is N2Os MAC
105
42
What is the OGPC of N2O
1.4
43
What is the BGPC of N2O
0.5
44
What is N2Os BP
-88
45
What is the SVP of N2O
5200
46
What are the side effects of N2O
Increase CBF Myocardial depression but SNS stimulation PONV Agranulocytosis
47
How is N2O metabolised
<0.01% to N2 B12 cobalt oxidised -> megaloblastic changes
48
What is N2Os critical temp and pressure
36.5 and 72
49
What is xenons MAC
71
50
What is the OGPC of xenon
1.9
51
What is the BGPC of Xenon
0.14
52
What is xenon's BP
-108
53
What are Xenon's side effects
Decrease HR and RR Increases TV (opp. to the rest) Analgesia
54
How is xenon metabolised
Eliminated in the lungs