Volatiles: Numbers to Know

Question 1

Blood:Gas PC of Desflurane

Answer 1

0.42 : 1

Question 2

Blood:Gas PC of Nitrous

Answer 2

0.46 : 1

Question 3

Blood:Gas PC of Sevoflurane

Answer 3

0.69 : 1

Question 4

Blood:Gas PC of Isoflurane

Answer 4

1.46 : 1

Question 5

Blood:Gas PC of Enflurane

Answer 5

1.9 : 1

Question 6

Blood:Gas PC of Halothane

Answer 6

2.54 : 1

Question 7

Minutes to recovery after 2 hours 1.6 MAC of Halothane

Answer 7

60

Question 8

Minutes to recovery after 2 hours 1.6 MAC of Isoflurane

Answer 8

30

Question 9

Minutes to recovery after 2 hours 1.6 MAC of Sevoflurane

Answer 9

12

Question 10

Minutes to recovery after 2 hours 1.6 MAC of Desflurane

Answer 10

8

Question 11

1 MAC =

Answer 11

ED50 @ 1 atm

Question 12

1.3 MAC =

Answer 12

ED95-99 @ 1 atm

Question 13

MAC awake =

Answer 13

0.3-0.5

Question 14

MAC bar =

Answer 14

1.7-2.0

Question 15

MAC values are based on

Answer 15

age 35-55
37 degrees C
760 mmHg
1 atm (sea level)

Question 16

MAC % of Nitrous

Answer 16

104

Question 17

MAC % of Desflurane

Answer 17

6.6

Question 18

MAC % of Sevoflurane

Answer 18

1.8

Question 19

MAC % of Enflurane

Answer 19

1.63

Question 20

MAC % of Isoflurane

Answer 20

1.17

Question 21

MAC % of Halothane

Answer 21

0.75

Question 22

Vapor pressure of Desflurane

Answer 22

669 torr

Question 23

Vapor pressure of Halothane

Answer 23

243 torr

Question 24

Vapor pressure of Isoflurane

Answer 24

238 torr

Question 25

Vapor pressure of Enflurane

Answer 25

175 torr

Question 26

Vapor pressure of Sevoflurane

Answer 26

157 torr

Question 27

Without bronchospasm, baseline pulmonary resistance unchanged by

Answer 27

1-2 MAC

Question 28

Ischemic preconditioning can occur as low as

Answer 28

0.25 MAC (still moving)

Question 29

Decreased CNS activity begins at

Answer 29

0.4 MAC (wakefulness changes to unconsciousness)

Question 30

Burst suppression occurs at

Answer 30

1.5 MAC

Question 31

Electrical silence occurs at

Answer 31

2 MAC

Question 32

Enflurane causes seizures especially at

Answer 32

2 MAC or PaCO2 < 30 mmHg

Question 33

Decreased amplitude & increased latency of SSEPs & MEPs can occur at

Answer 33

0.5-1.5 MAC

Question 34

Gas mixture ideal for SSEP & MEP monitoring

Answer 34

Nitrous 60% + 0.5 MAC = 1 MAC

Question 35

Volatiles start to increase CBF at

Answer 35

0.6 MAC (within minutes despite lack of BP change)

Question 36

Loss of auto-regulation in everyone occurs at

Answer 36

1 MAC

Question 37

Loss of auto-regulation w/ Halothane

Answer 37

0.5 MAC

Question 38

Loss of auto-regulation w/ Sevo

Answer 38

1 MAC

Question 39

Loss of auto-regulation w/ Iso & Des

Answer 39

0.5-1.5 MAC

Question 40

Volatiles start to increase ICP at ______; can increase ICP by _______

Answer 40

0.8 MAC; 7 mmHg

Question 41

Apnea occurs at

Answer 41

1.5-2.0 MAC

Question 42

Blunt hypoxic response occurs at ______ w/ _____% depression

Answer 42

0.1 MAC; 50-70% 1.1 MAC; 100%

Question 43

HPV occurs w/in _______ when regional blood flow is ______

Answer 43

5 minutes; half

Question 44

HPV maximal response lasts

Answer 44

2-4 hours

Question 45

% depression of HPV at 2 MAC

Answer 45

50

Question 46

Sevo increases HR after

Answer 46

>1.5 MAC

Question 47

Iso & Des increase HR at

Answer 47

lower concentrations

Question 48

Volatiles increase portal vein flow at

Answer 48

1-1.5 MAC

Question 49

Type 1 hepatotoxicity happens in ___% of patient _______ after exposure

Answer 49

20; 1-2 weeks

Question 50

Type 2 hepatotoxicity lasts for ______ after exposure

Answer 50

1 month

Question 51

Mortality of MH if untreated

Answer 51

80%

Question 52

PONV occurs in _______% of patients

Answer 52

25-30

Question 53

PONV occurs with Nitrous at

Answer 53

>0.5 MAC (50% of patients)

Question 54

Obstetric effects occur at

Answer 54

0.5-1 MAC

Question 55

Nitrous can't deliver even

Answer 55

1 MAC