VRL INFCTNS Flashcards
(44 cards)
● severe acute respiratory illness.
● Saudi Arabia in 2012
MIDDLE EAST RESPIRATORY SYNDROME (MERS-CoV)
What is the ETIOLOGIC AGENT OF MERS-CoV?
MERS-Coronavirus
What is the MODE OF TRANSMISSION OF MERS-CoV?
Close contact with infected person
What is the INCUBATION PERIOD OF MERS-CoV?
5 to 6 days, but can range from 2 to 14 days
What are the SIGNS AND SYMPTOMS OF MERS-CoV?
-FEVER
-COUGH
-SHORTNESS OF BREATH
-DIARRHEA
-NAUSEA AND VOMITING
What are the DIAGNOSTIC EXAMS for MERS-CoV?
● Polymerase chain reaction (PCR)
● ELISA
● Polymerase chain reaction (PCR) -
CONFIRMATORY TEST (used to detect viral RNA)
● ELISA-
SCREENING TEST used to detect the presence and concentration of specific antibodies
that bind to a viral protein.
What is the MEDICAL MANAGEMENT for MERS-CoV?
● Currently NO VACCINE is available to treat
MERS-COV
● TREATMENT IS SUPPORTIVE and based on a person’s
clinical condition
What are the PREVENTION for MERS-Cov?
● Wash hands often with soap and water for 20
seconds or use alcohol-based sanitizers
● Cover nose and mouth with tissue when coughing
or sneezing, then throw tissue in the trash.
● Avoid touching the eyes, nose and mouth with
unwashed hands.
● Avoid personal contact such as kissing or sharing
cups or eating utensils with sick people.
● Clean and disinfect frequently touched surfaces
such as doorknobs and toys
is a serious, potentially life-threatening viral infection
SEVERE ACUTE RESPIRATORY SYNDROME (SARS)
caused by the_____________ family, the SARS
associated coronavirus (SARS CoV).
Coronaviridae
● Symptoms related with the lower respiratory tract
● Initially discovered in China
● Characterized by a phase of cytokine storms
SEVERE ACUTE RESPIRATORY SYNDROME (SARS)
What are the SIGNS AND SYMPTOMS OF SARS?
● Fever 38 °C
● Fatigue
● Headaches
● Chills
● Myalgias
● Malaise
● anorexia
Less common features include the following:
- Sputum production
- Sore throat
- Coryza
- Nausea and vomiting -Dizziness
- Diarrhea
Stage 2 is the lower respiratory tract phase and is
characterized by:
● Dry cough
● Dyspnea
● Progressive hypoxemia in many cases
● Respiratory failure that requires mechanical
ventilation
What are the DIAGNOSTIC TESTS for SARS?
● PULSE OXIMETRY
● BLOOD CULTURES
● SPUTUM GRAM STAIN AND CULTURE
- To lure out other infection
●VIRAL RESPIRATORY PATHOGEN TEST- influenza test A and
B viruses and respiratory syncytial virus
- Lure out types of viral infection
● LEGIONELLA AND PNEUMOCOCCAL URINARY ANTIGEN
● WBC-decreased
●Mild hyponatremia and hypokalemia
●Elevated lactate dehydrogenase alanine
aminotransferase and hepatic transaminase
●Elevated creatine kinase level -Serum antibodies to
SARS-CoV in single serum specimen
●RT-PCR (reverse transcriptase polymerase chain
reaction)
●CHEST REDIOGRAPH - interstitial infiltrates
MEDICAL MANAGEMENT for SARS:
● CORTICOSTEROIDS
- Decrease mucus production
● ANTIVIRAL AGENTS (Ribavirin)
● PROTEASE INHIBITORS (Lopinavir, Ritonavir)
● INTERFERON
● MONOCLONAL ANTIBOIDES- emergency prophylaxis,
neutralizes virus activity in vitro and in vivo *
Intravenous immunoglobulin (IVIG)
● NITRIC OXIDE
● GLYCYRRHIZIN - inhibits vitro replication of the virus
● VACCINE- phase 1 clinical trial 2004
What is the ETIOLOGIC AGENT of SWINE FLU (H1N1)?
INFLUENZA A VIRUS SUBTYPE H1N1
What is the MODE OF TRANSMISSION of SWINE FLU (H1N1)?
CLOSE AND DIRECT CONTACT WITH INFECTED PERSON
What is the INCUBATION PERIOD of SWINE FLU (H1N1)?
ranges from 1 to 4 days with an average
of 2 days up to 7 days
-It is a type A influenza virus that affects pigs.
-It can pass to humans through contact or air contamination
SWINE FLU (H1N1)
What are SIGNS AND SYMPTOMS of SWINE FLU?
-COUGH
-FEVER
-SORE THROAT
-STUFFY OR RUNNY NOSE
-BODY ACHE
-HEADACHES
-CHILLS
-FATIGUE
What are DIAGNOSTIC TESTS for SWINE FLU?
-PCR
-RAPID ANTIGEN OR ANTIBODY IMMUNOASSAYS
-VIRAL CULTURE
What is the MEDICAL AND TREATMENT MANAGEMENT for SWINE FLU?
● Antipyretic
● Analgesics
● Increased fluid consumption
● Bedrest
● Antiviral agents (Oseltamivir/ Zanamivir
● Isolation
● Vaccination - Influenza virus vaccine trivalent
(Fluzone, Flucelvax)
● Influenza virus quadrivalent (Afluria Quadrivalent,
Fluarix)
What is the PREVENTION AND PRECAUTION for SWINE FLU?
● Seek medical care if suspected with H1N1
● Isolate patient immediately in a negative pressure
air handling
● Wash hands frequently
● Wear face mask
● Social distancing or avoid large gatherings
● Routine cleaning and disinfection
● Pre-exposure prophylaxis
What is the MODE OF TRANSMISSION of EBOLA VIRUS?
Direct contact with blood or bloody fluids, objects of a person infected with ebola and infected animals.