VTE Quiz

Question 1

Xarelto

Answer 1

Rivaroxaban

Question 2

Eliquis

Answer 2

Apixaban

Question 3

Pradaxa

Answer 3

Dabigatran

Question 4

Postoperative prophylaxis drugs

Answer 4

Dabigatran, Apixaban, Rivaroxaban
-Dabigatran hip replacement only

Question 5

non-valvular atrial fibrillation drugs

Answer 5

Dabigatran, rivaroxaban, apixaban, Edoxaban
-apixaban dosing is based on SCr
-edoxaban not recommended if CrCl is >95 mL/min

Question 6

DVT/PE treatment drugs

Answer 6

dabigatran, rivaroxaban, apixaban, Edoxaban
-dabigatran and edoxaban require 5-10 days parenteral anticoagulation
-edoxaban weight based dosing

Question 7

Secondary prevention of recurrent DVT/PE drugs

Answer 7

rivaroxaban, apixaban
-considered after 6 months of initial treatment

Question 8

VTE Prophylaxis drugs

Answer 8

-rivaroxaban
-patients in hospital

Question 9

Savaysa

Answer 9

Edoxaban

Question 10

Heparin considerations

Answer 10

Parenteral
Narrow therapeutic index
unpredictable
monitoring required
HIT
bleeding risk

Question 11

Warfarin considerations

Answer 11

oral
narrow therapeutic index
unpredictable drug interactions
monitoring
bleeding risk

Question 12

Low Molecular Weight Heparin considerations

Answer 12

parenteral
HIT
must transition to warfarin

Question 13

DTI considerations

Answer 13

parenteral
monitoring
limited use to HIT/CV
must transition to warfarin

Question 14

Xa inhibitors considerations

Answer 14

parenteral
must transition to warfarin

Question 15

NOACS/DOACS considerations

Answer 15

oral (some dosed BID)
no routine monitoring
directed bleeding reversal?

Question 16

UFH monitoring

Answer 16

aPTT- activated Partial Thromboplastic Time
goal: 1.5-2.5 time control
-weight based dosing (18 units/kg/hr infusion)

Question 17

LMWH monitoring

Answer 17

Enoxaparin (Lovenox)
-only consider in special populations
-anti Xa levels
-obtain trough for once daily dosing, 4 hours post dose for BID dosing

Question 18

Injectable Factor Xa inhibitors

Answer 18

Fondaparinux
-SC injection
-can be used for HIT
-treatment/prophylaxis

Question 19

IV direct thrombin inhibitors

Answer 19

Lepirudin (HIT)
Bivalirudin/Angiomax (HIT; UFH alternative during PCI)
Argatroban (HIT)

Question 20

CYP2C9*1 *2 and *3 and *8 alleles affect

Answer 20

-decrease warfarin clearance slower
-overall lower dose requirement

Question 21

VKORC1 1639A & G alleles affect

Answer 21

1639A(A) increases warfarin sensitivity–lower warfarin dose
1639G(G) increases warfarin resistance–hgiher warfarin dose

Question 22

antidote for UFH and LWFH

Answer 22

protamine sulfate

Question 23

antidote for dabigatran

Answer 23

Idarucizumab (praxbind)

Question 24

antidote for rivaroxaban and apixaban

Answer 24

adexanet alfa (andexxa)