Vulva Flashcards

1
Q

what structures are included in the vulva

A
  • skin and mucosa that is external to hymen

- labia majora, labia minora, mons pubis, vestibule

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2
Q

what epithelium lines the vulva

A

squamous epithelium

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3
Q

What is Bartholin cyst

A

cystic dilation of Bartholin gland

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4
Q

Where is Bartholin gland located? What does it produce? and where does is drain

A
  • each side of vaginal canal
  • mucus-like fluid
  • ducts into lower vestibule
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5
Q

what causes Bartholin cyst

A

inflammation and obstruction of gland

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6
Q

who usually gets Bartholin cyst

A

women of reproductive age

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7
Q

how does Bartholin cyst present clinically

A

unilateral, painful cyst

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8
Q

What is condyloma

A

watery neoplasm of vulvar skin

often large

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9
Q

What are common and less common causes of condyloma

A

common: HPV 6 or 11

less common: secondary syphilis ( condyloma latum)

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10
Q

Histologically, HPV-associated condylomas are characterized by what

A

Koilocytes

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11
Q

Do condylomas progress to carcioma

A

rarely (low risk HPV)

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12
Q

What is Lichen Sclerosis

A

thinning of epidermis and fibrosis (sclerosis) of dermis

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13
Q

clinical presentation of Lichen Sclerosis

A

white patch ( leukoplakia) with parchment-like vulvar skin

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14
Q

Lichen sclerosis is seen in who

A

postmenopausal women

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15
Q

Is lichen sclerosis benign or malignant

A

Benign

- slightly increased risk for squamous cell carcioma

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16
Q

What is lichen simplex chronicus

A

hyperplasia of vulvar squamous epithelium

17
Q

how does lichen simplex chronicus present

A

leukoplakia with thick, leathery vulvar skin

18
Q

is lichen simplex chronicus benign or malignant

A

benign

no increased risk of squamous cell carcinoma

19
Q

what is vulvar carcinoma

A

carcinoma arising from squamous epithelium lining vulva

20
Q

how does vulvar carcinoma present

A

leukoplakia

21
Q

Etiology of vulvar carcinoma

A

HPV related or non HPV related

22
Q

HPV related vulvar carcinoma is due to which strands of HPV

A

HPV 16 and 18

23
Q

What are risk factors related to HPV exposure

A

multiple sex partners

early first age of intercourse

24
Q

who does HPV usually occur in

A

women of reproductive age

25
HPV related vulvar carcinoma arises from what condition
vulvar intraepithelial neoplasia (VIN)
26
what is VIN- vulvar intraepithelial neoplasia
dysplastic precursor lesion - kiolocytic change - disordered cellular maturation - nuclear atypia - increased mitotic activity
27
non-HPV related vulvar carcinoma arises from what condition
long-standing lichen sclerosis
28
who usually gets non-HPV vulvar carcinoma
elderly women
29
what is extramammary paget disease
malignant epithelial cells in EPIDERMIS of vulva
30
how does extramammary paget disease clinically present
erythematous pruritic ulcerated vulvar skin
31
characterize paget disease of nipple
malignant epithelial cells in EPIDERMIS of nipple
32
what is the difference between paget disease of nipple and extramammary paget disease
nipple: associated with underlying carcinoma extramammary: carcinoma in situ, no underlying carcinoma
33
what are biomarkers for extramammary paget cells (impt to distinguish from melanoma)
PAS+ Keratin + S100-
34
What are biomarkers for Melanoma of vulva
PAS- Keratin - S100 +