W2 L4 - One molecule, many friends Flashcards
(13 cards)
1
Q
Comparison between brand name and generic medicines
A
- Same API, different excipients/branding
- Generic = cheaper due to no Research and Development/marketing cost
2
Q
what does MHRA stand for
A
Medicines and Healthcare products Regulatory Agency
3
Q
Requirements for the sale of a medicine
A
- Marketing Authorisation (MA) - acquired after assessment by the regulator (MHRA) to meet quality, safety and efficacy standards for its intended use
- Product Licence - Format: PL 12345/0001. same PL, same product
4
Q
are excipients inert
A
no, may have be pharmacologically active
5
Q
what’s a vehicle
A
the main carrier or base in a formulation that delivers the active drug; it helps dissolve, suspend, or distribute the drug evenly. Examples: purified water (liquids), oil (ointments).
6
Q
what’s a complexing agent
A
- chelating agent
- a substance that binds to metal ions to form stable, water-soluble complexes. This prevents metal ions from causing instability, degradation, or discoloration in the formulation.
7
Q
role of water in a SUSPENSION
A
- vehicle/continuous medium
- its a solvent for the excipients but not for the drug
8
Q
Examples of Preservatives
A
Benzalkonium chloride, parabens
9
Q
Examples of Buffers
A
Phosphates, boric acid
10
Q
Examples of pH Adjuster
A
NaOH, HCl
11
Q
Examples of Sweeteners/Flavours
A
Saccharin, glycerol, sucrose, flavourings
12
Q
Examples of Thickeners
A
Hypromellose
13
Q
Examples of Chelating agents
A
EDTA
