W4 Local Anaesthesia Flashcards
(113 cards)
Describe what local anaesthetics are in dentistry?
Local anaesthetic is a loss of sensation to a circumscribed area of the body. Used in dentistry to create reversible blockage of pain/sensation signals in peripheral nerves. Natural vasodilators.
Does LA stimulate or depress CNS?
Both
What can LA cause on the heart?
Antidysrythmias
Do smooth muscles; relax or constrict during LA?
Relax; inhibition of neuromuscular transmission in skeletal muscle.
What is added to LA to stabalise the solution?
Salt (hydrochlorides) this makes the molecules stable and sobuable in water.
What is the pH base of LA?
pka 8-9. In ECF 7.4pH, it is positively charged and called a CATION.
What is pka?
Strength of acid.
What determines speed of onset? (pKa)
Determeined by pKa of the solution and the pH of the surrounding fluids.
What does it mean if an anaesthetic has a high lipid solubility?
HIGH lipid solubility is more potent as they produce more affection conduction blockade at lower concentration that less sol anaesthetics.
LOWER percentage sol, smaller amount required.
Describe binding affinity on LA and how it works in onset of action
Drugs with ↑ protein binding affinity will bind to plasma proteins for longer, resulting in an additional reservoir once the unbound drug has diffused away from site/metabolized.
Also will bind to Na+ channel receptor for longer.
How is local anesthetic carried away from site?
Vasodilator action increases perfusion of LA in local area with blood,.
Anesthetic agent is carried away from site more rapidly for metabolisim.
Potential for ↑ bleeding at sit of infection
What affects the mode of action of LA of ↓ tissue pH?
Low tissue pH. eg. Inflammation which affects the speed of onset. This has ↓ pH outside of the nerve, this means more LA solution present in cation (+). Less free base avail to penetrate nerbe membrane to action on Na receptor
What affects the mode of action of LA of ↑ tissue vascularity?
Inflammation affects th duration of action. More blood vessels present in local area, therefor greater opportunity for LA to be removed from injection sit. & spread.
Define speed and mechanism of absorption of LA
Speed can be influced by the chemical nature of the drug. Site of injection
- Local blood flow
- Vasoconstriction.
Greater th absoprtion the greater potential for systemic effects.
How does metabolism make LA less lipophillic?
Alters the chemical properties of drugs to make them less lipophillic (disolvable) to enable excretion.
Occurs in the liver, blood, plasma and lungs.
How does metabolisim enable LA excretion?
Alters the chemical properties of drugs to make them less lipophillic to enable excretion.
Occurs in the liver, blood, plasma and lungs.
Describe Esters as functional groups
Procain/Novocaine, Tetracaine.
Metabolisim: rapidly hydrolyzed in plasma by pseudocholinesterease. It is excreted in urine - can be related to allergic reactions. It can ↑ potential for toxicity. Can be hereditry.
What anaesthetics are Amides groups?
Where are they metabolised?
What may affect metabolisim?
Lignocaine/Lidocaine. Prilocaine, Articaine, Bupivacaine, Mepivcaine.
Metabolised in the liver.
- Rate of breakdown is dependent on hepatic flow.
- Secondary metabolism in lungs.
Things that may affect metabolism are hypotension, congestive hart failure, cirrhosis.
What is the onset of topical anaesthetics?
2-5min
What is the duration of topical duration?
15-20 min
What are the indication for topical anesthetics?
Prior to anesthetic injection on mucous membranes.
Contraindicated: allergy, eating, drinking
What are the constituants of LA?
ADD MORE INFO!
- Anaesthetic agent
- Stabilisers
- Vasoconstrictors
- Antioxidants
- Preeservativees
- Water
What effect does adrenaline have on the body in LA?
Naturally occurs in the body. Binds to adrenreceptors.
SYMPATHOMIMETIC. Heart: ↑ HR, ↑ Co2 coronary artery dilation ↑ BP
Blood vessels:
Acts on: lungs (bronchiolar muscle relaxation)
GI tract (↓ gut contractiability)
metabolisim (inhibits insulin release)
Dfine Felypression
It causes vasoconstriction by acting on smooth muscle of the muscular beds, with greater effects on the venous sude of the peripheral circulation.