Wake promoting drugs and the Latter Flashcards
1
Q
What are Wake-promoting drugs (WPD)?
A
Narcolepsy is a rare sleep disorder (0.02- 0.06) characterised by excessive daytime sleepiness. It is possibly an autoimmune disorder caused by hypocretin deficiency
2
Q
What is caffeine?
A
Caffeine is an adenosine receptor antagonist, blocking the A1a receptor therefore reducing the inhibitory effects of adenosine.
3
Q
Dopamine synthesis
A
DA is synthesised from L-tyrosine in the cytoplasm of the neurons
DA is then converted into norepinephrine (NE) by DA β-decarboxylase
4
Q
Amphetamines
A
They block the reuptake of monoamines, especially dopamine and norepinephrine transporters
Therapeutically, they are used to treat ADHD and narcolepsy
Substance misuse and C/I: arrhythmia
