Warfarin Flashcards
(4 cards)
1
Q
MOA
A
Inhibits synthesis of clotting factor 2,7,9 and 10 therefore stopping blood clothing,
Antagonist of Vit K which is a essential cofactor in the synthesis of clotting factors 2,7,9 and 10.
2
Q
Indication
A
Prevention and Treatment of venous thromboembolism
Prevention of thromboembolism in pts with prosthetic heart valves
Prevention of stroke in pt with myocardial infarction and increase embolic risk
Pts with AF
3
Q
Side Effect
A
Haemorrhage
Tissue Necrosis
Alopecia
Purple discoloration of toes
Hepatic dysfunction
4
Q
NC
A
Takes serval day to take clinical effect
Effect differ in every pt
Dosage is important
Guided by international normalised ration (INR)
INR should be between 2-3
Requires regular IRN test
