Water & pH Flashcards

0
Q

Percentage of Intracellular water

A

40% (2/3)

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1
Q

Predominant chemical component of living organisms; Irregularly, slightly skewed tetrahedron - oxygen at center and 2 hydrogens at corners

A

Water

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2
Q

Percentage of Extracellular water

A

20% (1/3)

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3
Q

Percentage of Interstitial fluid

A

15%

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4
Q

Percentage of Blood Plasma

A

5%

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5
Q

Properties of Water

A
Dipole
High dielectric constant
Forms hydrogen bonds
Excellent nucleophile
Amphoteric
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6
Q

Acts as both an acid and base

A

Amphoteric

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7
Q

Has hydrophilic and hydrophobic parts

A

Amphipathic

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8
Q

The negative log of hydrogen ion concentration; Measure alkalinity or acidity

A

pH

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9
Q

What is the normal pH of blood?

A

7.35-7.45

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10
Q

Proton donors

A

Acids

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11
Q

Proton acceptors

A

Bases

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12
Q

High H+
Low pH
Low pKa

A

Acids

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13
Q

Low H+
High pH
High pKa

A

Bases

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14
Q

Causes of High Anion Gap Metabolic Acidosis

A
Methanol
Uremia
Diabetic Ketoacidosis
Paraldehyde and Propylene Glycol
Isoniazid
Lactic Acidosis (Sepsis, Shock)
Ethylene Glycol
Salicylates
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15
Q

Used to calculate the concentration of a weak acid (HA) and its conjugate base (A-)

A

Henderson-Hasselbach Equation

16
Q

pH<pKa
Acid is uncharged
Base is charged

A

Protonated

17
Q

pH>pKa
Acid is charged
Base is uncharged

A

Unprotonated

18
Q

Mixture of weak acid and its conjugate base that can resist a change in pH when protons are produced or consumed

A

Buffers

19
Q

Physiologic Buffers

A

Bicarbonate (most important extracellular)
Proteins (most important intracellular)
Orthophosphate