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Water soluble vitamins Flashcards

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1
Q

What are things that could potentially cause damage to vitamins?

A

Light

Oxidation

Cooking

Storage

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2
Q

How is absorption of water and fat soluble vitamins different?

A

Water soluble vitamins are absorbed into bloodstream and are excreted in urine.

Fat soluble vitamins are absorbed into lymph then blood. In blood they are carried by protein carriers and stored in cells that typically store fat.

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3
Q

What is a big risk factor for fat-soluble vitamin toxicity?

A

Fat-soluble vitamins are likely to reach toxic levels with

supplement use

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4
Q

What is the Estimated Average Requirement and how is this taken into account when deciding an RDI?

A

Different people have different requirements for certain nutrients. EAR takes into account 50% of the population.

RDI is set at a value well above the EAR and as a result covers 98% of the population.

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5
Q

What is bioavailability?

A

Bioavailability is the rate and extent that a nutrient

is absorbed and used

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6
Q

What other forms can vitamins be consumed in?

A

Precursors (provitamins) are
consumed in an inactive form and become active
vitamins in the body

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7
Q

What is the function of thiamin (Vitamin B1)?

A

Thiamin is involved in energy metabolism as part of

the coenzyme thiamin pyrophosphate (TPP)?

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8
Q

What is the RDI of thiamin?

A

Men: 1.2mg/day

Women:1.1mg/day

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9
Q

What are the symptoms of thiamin deficiency?

A

Enlarged heart and possible cardiac failure

Muscular weakness

Apathy, poor short-term memory, confusion, and
irritability

Anorexia and weight loss

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10
Q

What deficiency causes Wernicke-Korsakoff syndrome?

A

Thiamin deficiency (caused by alcohol abuse)

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11
Q

What are the effects of alcohol consumption on thiamin?

A

Alcohol decreases absorption and increases excretion of vitamin B1.

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12
Q

Which vitamin deficiency causes the disease beriberi?

A

Thiamin

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13
Q

What is the difference between dry and wet beriberi?

A

Wet beriberi reflects damage to the cardiovascular
systems and presents with oedema (accumulation of vasodilators)

Dry beriberi reflects damage to the nervous system and
presents with muscle wasting

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14
Q

How common is the incidence of thiamin toxicity?

A

There are no reported toxicities

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15
Q

What are some food sources of vitamin B1?

A

Wholegrain, fortified or enriched grain products

Moderate amounts in all foods ( I remember this using its function; thiamine is involved in TPP function which is a step shared by all living creatures. We eat other living things so we get some vitamin B1 from other things.)

Yeast spreads (Vegemite)

Pork, my favourite yum

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16
Q

How does thiamin respond to cooking?

A

Vitamin is destroyed by heat so it needs to be steamed or microwaved.

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17
Q

What is the function of riboflavin?

A

Riboflavin is involved in energy metabolism

Flavin mononucleotide (FMN) and flavin adenine dinucleotide
(FAD) are the reducing equivalent coenzyme forms
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18
Q

What is the RDI of riboflavin?

A

Men: 1.3mg/day
Women: 1.1mg/day

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19
Q

What are the symptoms of riboflavin deficiency? What is the name of the condition?

A

‘A’riboflavinosis:

Inflammation of the membranes of the mouth, skin, eye
and GI tract.

Sore throat and cracks and redness at corner of mouth.

Skin lesions covered with greasy scales.

Painful, smooth, and purplish red tongue

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20
Q

How common is the incidence of riboflavin toxicity?

A

No reported toxicities

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21
Q

What are some sources of vitamin B2?

A

Milk products; including yoghurt and cheese.

Enriched and whole grains.

Liver

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22
Q

Is vitamin B2 destroyed by cooking?

A

No

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23
Q

What destroys vitamin B2?

A

ultraviolet light.

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24
Q

What is the function of niacin (vitamin B3)?

A

Glucose, lipid, fat, and alcohol metabolism (NAD+ coenzyme)

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25
What is the RDI of niacin?
Since body can obtain niacin from dietary tryptophan the RDI is in niacin equivalents (NE); 60mg trp = 1mg niacin In men: 16NE/day In women: 14NE/day
26
What is the upper intake level of niacin?
35mg/day
27
How can niacin be destroyed or lost?
It can be lost into water
28
What other functions does Niacin have?
It can transport electrons to pyruvate during anaerobic respiration (lactate production)
29
What are the deficiencies associated with niacin?
diarrhoea, abdominal pain, and vomiting inflamed, swollen, smooth and bright red tongue depression, apathy, fatigue, loss of memory, and headache Rash when exposed to sunlight the four Ds: Diarrhea Dermatitis Dementia Death
30
Deficiency in what vitamin results in pellagra?
Vitamin B3 (NIacin)
31
What are the symptoms of niacin toxicity?
Niacin flush (painful tingling sensation results from dilated capillaries) painful flush, hives and rash excessive sweating blurred vision liver damage impaired glucose tolerance
32
What are some niacin sources?
Milk Eggs, meat, poultry, fish whole-grain and enriched breads and cereals nuts and all protein-containing foods
33
How can niacin bioavailability in food be improved?
Treating food with alkaline
34
What is the function of pantothenic acid?
Pantothenic acid is involved in energy metabolism | as a part of coenzyme A
35
What is the RDI of pantothenic acid?
Men: 6mg/day Women: 4mg/day
36
What are the symptoms of pantothenic acid deficiency?
vomiting, nausea, and stomach cramps • insomnia and fatigue • depression, irritability, restlessness, and apathy • hypoglycaemia and increased sensitivity to insulin
37
What are the symptoms of pantothenic acid toxicity?
There are no reported toxicities
38
What are some pantothenic acid food sources?
widespread in foods – organ meats – mushrooms, avocados, and broccoli – wholegrains
39
What factors cause loss of pantothenic acid from food?
Freezing Canning Refining
40
What are vitamin B6 food sources?
meats, fish, poultry and liver – legumes and soy products – non-citrus fruits – fortified cereals
41
What are some symptoms of vitamin B6 toxicity?
depression, fatigue, irritability, and headaches • nerve damage causing numbness and muscle weakness leading to inability to walk • convulsions • skin lesions
42
What is the upper level intake for vitamin B6?
50mg/day
43
What are the symptoms of vitamin B6 deficiency?
Scaly dermatitis • Anaemia – small cell type • Depression, confusion, abnormal brain wave pattern, and convulsions – Diminished synthesis of key neurotransmitter – Accumulation of product of tryptophan metabolism in brain
44
What is the coenzyme form of vitamin B6?
pyridoxal phosphate
45
What kind of reactions is vitamin B6 involved in?
Participates in reactions involving amino group (NH2) transfer and decarboxylation: Amino acid metabolism – Conversion of tryptophan to niacin or serotonin (a neurotransmitter) Urea metabolism Decarboxylation of histidine – Production of red blood cells
46
What factors can destroy vitamin B6?
Heat
47
What is the function of biotin?
Part of a coenzyme used in energy metabolism, biotin assists in glycogen synthesis, fat synthesis, and amino acid metabolism. Involves in 1-carbon transfer reactions • Example, synthesis of oxaloacetate (4C) from pyruvate (3C) and CO2
48
What is the RDI for biotin?
Men: 30 micrograms/day Women: 25 micrograms/day
49
What are some biotin deficiency symptoms?
depression, lethargy, and hallucinations • numb or tingling sensation in the arms and legs • red, scaly rash around the eyes, nose and mouth • hair loss
50
Name some biotin food sources.
widespread in foods – organ meats, egg yolks and fish – soybeans – wholegrains Biotin can also be synthesised by intestinal bacteria (hence the name)
51
Good summary video for water soluble vitamins (including vitamin C)
https://www.youtube.com/watch?v=lXgXTx1-d1k
52
What is the function of folate?
Involved in synthesis of DNA and formation of new cells
53
What other vitamin does folate work with to carry out its function?
vitamin B12 is required for the activation of folate.
54
What is the naturally occuring form of folate?
polyglutamate
55
What is folate's RDI?
400 micrograms/day
56
Why is folate calculated in DFE?
bioavailability is different in different foods.
57
What birth defects are associated with folate deficiency?
spina bifida anencephaly
58
How does alcohol contribute to folate deficiency?
Alcohol damage GI tract epithelial cells reducing reabsorption of folic acid • Deficiency of folic acid leads to deterioration of GI tract further increasing folate deficiency
59
How is folate related to heart disease?
Folate breaks down homocysteine. High levels of homocysteine and low levels of folate cause heart disease.
60
How is folate related to cancer?
Sufficient folate may protect against cancer but enhance progression after it has begun.
61
What are symptoms of folate deficiency?
impaired cell division + Protein synthesis. Smooth, red tongue Mental confusion, weakness, fatigue, irritability and headaches. macrocytic anemia aka megaloblastic anemia.
62
What are the symptoms of folate toxicity?
No known toxicties. It masks vitamin B12 deficiency symptoms.
63
What are some folate sources?
fortified grains Leafy green vegetables Legumes and seeds Liver
64
What is the function of vitamin B12?
Synthesis of new cells maintaining nerve cells reforming folate coenzymes breaking down fatty acids and amino acids.
65
What are the coenzyme forms of vitamin B12?
methylcobalamin (active) deoxyadenosylcobalamin
66
What is the RDI of vitamin B12?
2.4 μg/day
67
What are the vitamin B12 deficiency symptoms?
exacerbate folic deficiency related megalomaniac anaemia fatigue and depression degeneration of peripheral nerves progressing to paralysis
68
What are some causes of vitamin B12 deficiency?
atrophic gastritis can cause vitamin B12 deficiency because it inhibits it's release from food proteins.
69
What are the toxicity symptoms of vitamin B12?
No known toxicities.
70
What are some vitamin B12 sources to remember?
Meat, fish, poultry, shelfish Milk, cheese and egg Fortified cereals
71
How is vitamin B12 absorbed at the intestine?
Vitamin B12 binds with intrinsic factor before it is absorbed.
72
What factors destroy vitamin B12?
Microwave cooking
73
How does mitomycin affect cells?
Mitomycin cross links to DNA strands preventing replication
74
How does doxorubicin affect cells?
Doxorubicin intercalates DNA
75
How does taxol affect cells?
Taxol targets microtubules which prevents cell replication.
76
How can folate be used in cancer therapy?
Folate receptor is overexpressed in cancer cells and so folate is attached to drugs to target anti-cancer chemicals directly to the cancer cells.
77
What are some methods for targetting medical therapies to cancer cells?
Antibodies are often used to target medicine to cancer. Peptides Folate
78
Why is folate linked to the drug by an acid labile linker?
Acid labile linkage is required for release of the drug the targeted cancer cells.
79
What are the symptoms associated with vitamin B deficiencies in general?
glossitis (inflamed tongue) and cheilosis (scaling of lips) are two symptoms common to B vitamin deficiencies
80
What is the function of vitamin C?
an antioxidant cofactor in collagen formation As a cofactor in other reactions • hydroxylation of carnitine • converts tryptophan to neurotransmitters • Synthesis of some hormones Vitamin C needs to increase • during body stress, i.e. infections, burns, extremely high or low temperatures, heavy metal intakes, certain medications, and smoking – As a cure for the common cold • some relief of symptoms • vitamin C deactivates histamine like an antihistamine – Effectiveness in disease prevention is still being researched
81
What is the RDI for vitamin C?
adults: 45mg/day smokers: 80mg/day
82
What condition results from scurvy and what are its symptoms?
Scruvy; symptoms: rough skin and blotchy bruises bleeding gums and loose teeth pinpoint haemorrhages poor wound healing and frequent infections atherosclerotic plaques bone fragility and joint pain anemia (small cell) Muscle degeneration and pain, hysteria, and depression
83
What are the symptoms of vitamin C toxicity?
Acidosis – Toxicity symptoms • nausea, abdominal cramps, diarrhoea, headache, fatigue and insomnia • hot flashes and rashes • interference with medical tests, creating a false positive or a false negative • aggravation of gout symptoms, urinary tract infections, and kidney stones
84
What is the upper level for vitamin C consumption?
Upper level for adults unable to be determined. Thought to be 1000 mg/day
85
What are some sources of vitamin C?
citrus fruits, cantaloupe, strawberries, papayas and mangoes – cabbage-type vegetables, dark green vegetables like capsicum and broccoli, lettuce, tomatoes and potatoes.
86
What factors destroy vitamin C?
heat and oxygen

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