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WBC Flashcards

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1
Q

Predominant WBC in adults

A

Neutrophil

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2
Q

Predominant WBC in children <=4 year of age

A

Lymphocyte

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3
Q

On dtermining WBC maturity, MOST valuable and reliable criterion is

A

Nuclear chromatin patter

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4
Q

Earliest recognizable granulocytic precursor using light microscopy

A

Myeloblast

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5
Q

shows the presence of dispersed Primary Azurophilic granules in the cytoplasm, the number of granules does NOT exceed 20 per cell

A

Type II myeloblast

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6
Q

larger than Myeloblast, ‘‘hof’’ is usually seen in normal promyelocyte, full of primary azurophilic/nonspecific granules

A

Promyelocyte

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7
Q

Hollow in the cytoplasm of a cell that lodges the nucleus

A

Hof

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8
Q

LAst stage capable of mitosis; stage of synthesis of secondary granules (specific granules)

A

Myelocyte

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9
Q

may look very similar to the promyelocyte

A

Early myelocyte

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10
Q

patches of grainy pale pink cytoplasm representing secondary granules start to become obvious in the area of the Golgi apparatus

A

Dawn of Neutrophilia

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11
Q

Nucleoli are absent. Synthesis of Tertiary granules
Juvenile cell
First stage of Nuclear indentation

A

Metamyelocyte

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12
Q

Stab cell or Staff cell. Youngest granulocytic to normally appear in Per. Blood
Secretory granules may begin to form

A

Band cell

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13
Q

Tertiary granules is also known as

A

Gelatinase

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14
Q

usually caused by a shift of marginated cells to the circulatory pool

A

Pseudoneutrophilia

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15
Q

associated with drugs: amidopyrine and cephalosporin. aka. Extreme Neutropenia

A

Agranulocytosis

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16
Q

caused by T. spiralis, possibly produced the highest eosinophil count

A

Trichinosis

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17
Q

Associated conditions in Basophilia
‘’ I H U E’’

A

Immediate hypersensitivity rxn
Hypothyroidism
Ulcerative colitis
Estrogen theraphy

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18
Q

predominant type of Lymphocyte in normal adult blood
composed mostly of nucleus
scanty cytoplasm

A

Small lymphocyte

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19
Q

final maturation stage of B lymphocyte
‘‘tortoise shell’’, ‘‘cartwheel’’ or ‘‘clock-face’’

A

Plasma cell

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20
Q

may contain round discrete globules called Russel bodies
‘‘dark-blue’‘/sea-blue/ cornflower in color

A

Cytoplasm of Plasma cell

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21
Q

most common malignant disease of plasma cells

A

Plasma cell myeloma

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22
Q

Functions of macrophage
‘’ P S R P’’

A

Phagocytosis
Synthesis of Nitric oxide
Release of IL-1
Produce transcobalamin

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23
Q

Mesanglial cells (Renal macrophage)

A

Kidneys

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24
Q

Dendritic cells

A

Lymph nodes

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25
Type A cells
Synovial tissue
26
Microglial cells
Brain
27
Most common WBC in the normal peripheral blood, first to reach the infected areas then Monocyte
Neutrophil
28
neutrophil move in what manner
Zigzag
29
Neutrophils share a common progenitor with monocytes
GMP (Granulocyte Monocyte Progenitor)
30
Major stimulatory cytokine for neutrophil production
G-CSF Granulocyte-Colony Stimulating Factor
31
Half life of neutrophils in the blood
7 hours
32
extracellular threadlike structures thought to represent chains of nucleosome from unfolded nuclear chromatin material
NETs
33
3 major function of Neutrophil
1. Phagocytosis 2. Generation of NETs 3. Secretory function
34
an enzyme that exhibits bactericidal, fungicidal and viricidal properties
Myeloperoxidase
35
aka. Muramidase an anti-microbial enzyme
Lysozyme
36
an iron binding protein that competes w/ bacteria for Iron
Lactoferrin
37
contribute to tight stationary binding between neutro and endothelial cells
CD11b/ CD18
38
Neutrophil is the only WBC that has an activity with the enzyme
Alkaline phosphatase
39
Most specific cytokine for Eosinophilic Lineage
IL-5
40
hallmark of allergic disorders
Eosinophilia
41
Circulating half life of Eosinophil
18 hours
42
Survival time of eosinophils in human tissue ranges from
2 to 5 days
43
disintegration products of eosinophils, hexagonal, bipyramidal crystals
Charcot-leyden Crystals
44
Color of Charcot-Leyden crustals in Hematoxylin
Black
45
Color of Charcot-Leyden crystals in Eosin
Red
46
Color of Charcot-Leyden crystals in Trichome stain
Purplish red
47
Formed during the Promyelocyte stage, last to be released during exocytosis
Primary (Azurophilic) Granules
48
Formed during the Myelocyte and Metamyelocyte stages, Third to be released
Scondary (Specific) Granules
49
Formed during the Metamyelocyte and Band stages, Second to be released
Tertiary (Gelatinase) Granules
50
Formed during the Band and Segmented neutrophil stages, First to be released
Secretory Granules
51
Formed during the Promyelocyte stage. Contain Charcot-Leyden Crystal protein
Primary Eosinophil Granules
52
Formed througout the remaining maturation of Eosinophil
Secondary granules
53
happens whene xtracellular intact granules are deposited during cell lysis
Cytolysis
54
secretory vesicles remove specific proteins from secondary granules, travel to Plasma membrane fuse and empty proteins into extracellular space
Piecemeal degranulation
55
granules fuse together within the eosinophil prior to fusing with the plasma membrane
Compound exocytosis
56
Basophil Granules '' H I C I''
Histamine Interleukin-4 Chondroitin sulfates Interleukin-13
57
a dye that can bind with acid mucopolysaccharides ain blood cells to form metachromatic complexes
Toluidine blue
58
histochemically defined as a reaction product color that is considerably different from the color of the dye itself
Metachromasia
59
valuable in identifying basophil and mast cells
Toluidine blue stain
60
Lifespan of Basophil
60 hrs
61
round horse-shoe shaped or lobulated Chromatin: lace-like or stringy vacuoles present
Monocyte
62
Cytoplasm (Monocyte):abundant blue-gray containing fine indistinct granules called
Azure dust (ground-glass appearance)
63
Monocyte are best identified by their strong positive reaction with
Nonspecific Esterase stain
64
Monocyte are said to be rich in
Muramidase
65
Monocyte remain in the circulation roughly
3 days

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