WBC CBC

Question 1

complex process where blood cells form, proliferate, differentiate, and mature

Answer 1

hematopoiesis

Question 2

where does hematopoiesis occur in adults?

Answer 2

bone marrow

Question 3

originator stem cell of all blood

Answer 3

multi potential stem cell

Question 4

lymphoid stem cell line

Answer 4

lymphocyte (B and T cells)

Question 5

myeloid cell line

Answer 5

basophils, eosinophils, neutrophils, monocytes, platelets

Question 6

total number of leukocytes

Answer 6

WBC

Question 7

percentages of different types of blood cells

Answer 7

differential

Question 8

normal value of WBC

Answer 8

4500-10500/mm3

Question 9

bacterial infection = ____ WBC

Answer 9

HIGH

leukocytosis

Question 10

viral infection = ___ WBC

Answer 10

LOW

leukopenia

Question 11

leukocytosis value

Answer 11

> 10,000/mm3

Question 12

leukopenia value

Answer 12

< 4000/mm 3

Question 13

leukocytosis

Answer 13

elevated WBC

increase in ONE type of cell (infection, leukemia, drugs -steroids)

Question 14

leukopenia

Answer 14

low WBC

viral infection, bone marrow depression, hyperspelnism

Question 15

leukomoid reaction

Answer 15

marked increase in WBC (50,000 - 100,000 /mm3)

due to infection but increase is only temporary

Question 16

panic values for total WBC

Answer 16

<500 or >30,000

Question 17

“polys” listed in differential

Answer 17

bands, segmented neutrophils, eosinophils and basophils

aka granulocytes

Question 18

what leukocytes are most abundant in a diff

Answer 18

segs/polys (neutrophils) 50-70%

followed by lymphocytes (20-30%)

Question 19

absolute count

Answer 19

obtained by multiplying relative % by total WBC count

used when you need to know actual numbers (i.e chemotherapy)

Question 20

types of neutrophils

Answer 20

segmented (mature)

bands (immature)

Question 21

band neutrophil

Answer 21

00-5% of total WBC

nucleus is NOT segmented, increases during infections

Question 22

“left shift”

Answer 22

increased in bands on a CBC

seen in association with increased WBC in infection

Question 23

segmented neutrophils

Answer 23

most numerous of all WBC (50-70%)

primary defense against microbes

enzymes are found in granules that responsible for body tissue

Question 24

hypersegmented neutrophil

Answer 24

mature neutrophil with more than 5 lobes

Question 25

conditions that might have hyperhsegmented neutrophil

Answer 25

mesoblastic anemia vitamin b12 /folate deficiencies hereditary

Question 26

ANC

Answer 26

count used to determine levels of neutrophil determines if safe to give chemo

Question 27

ANC value | low risk of infection

Answer 27

1,000-1,5000

Question 28

ANC value | moderate risk of infection

Answer 28

500-1,000

Question 29

ANC value | high risk of infection

Answer 29

< 500

Question 30

eosinophil levels and function

Answer 30

0-5% of WBC parasite (worm) defense, allergic/hypersensitivity rex granules have histamin

Question 31

basophils value and function

Answer 31

0-1% of WBC grnules have heparin and histamine increased in leukemia and chronic inflammation

Question 32

lymphocytes value and function

Answer 32

20-40% of EBC small, mononuclear, no granules high in viral infections source if Igs (B cells) and cellular immunity (T cells)

Question 33

phagocytic cells that preform scavenger functions

Answer 33

monocytes produce antiviral Interferon 0-7% of CBC

Question 34

abnormal findings on CBC (3)

Answer 34

1. immature WBCs 2. inclusion bodies 3. Morphology changes

Question 35

blast cells

Answer 35

should never be seen on peripheral blood smear usually indicate leukemia

Question 36

cytoplasmic infusions

Answer 36

WBC abnormalities associated with infection 1. toxic granulation 2. Dohle bodies 3. Auer rods

Question 37

toxic granualtion (4)

Answer 37

black/purple cytoplasm granules found in infection, inflammation, burns, drug poisoning

Question 38

Dohle bodies

Answer 38

lg. blue masses in cytoplasm of neutrophils occur in myeloproliferative syndromes, infections, burns, inflammatory diseases

Question 39

Auer rods

Answer 39

cytoplasm of BLAST cells rod-like, purple inclusions pathognomonic of AML

Question 40

other morphology changes seen on WBC

Answer 40

1. smudge cells | 2. atypical lymphocytes

Question 41

smudge cells

Answer 41

disintegrating nucleus of ruptured WBC common in CLL

Question 42

atypical lumphoctes

Answer 42

reactive or activated lymphocyte role unknown, immune cell most often seen in infectious mono

Question 43

Infectious mononucleosis will exhibit

Answer 43

lymphocytosis and atypical lymphocytes

Question 44

platelets are produced in the _____ from ____

Answer 44

bone marrow from megakaryocytic no nucleus, survive 8-10 days

Question 45

normal platelet levels

Answer 45

140,000 - 400,000 /mm3

Question 46

panic value of platelets

Answer 46

< 20,000 spontaneous bleeding