WBC disorders Flashcards
Hematopoietic stem cell are CD ____
CD 34+
Hematpoitic stem cell can develop into (2)
myeloid , lymphoid stem cells
Myeloid stem cells can form what (4) cells
Erythroblasts , myeloblast(Neutro, Baso,Eosino) Monoblast, Megakaryoblast
lymphoid stem cell can form what
b lymphoblast and t lymphoblasts
Low WBC count
less than 5K
high WBC count
more than 10K
neutropenia
decrease number of neutrophils
two causes of neutropenia
drug toxicity and severe infection (gram - sepsis)
treatment for neutropenia
GM-CSF or G-CSF
what is lymphopenia
decreased number of circulating lymphocytes
name the four causes of lymphopenia
immunodeficiency , high cortisol state , auto immune destruction, whole body radiation
name the two causes for leukocytosis
bacterial infection/tissue necrosis , high cortisol state
most susceptable to whole body radiation
pymphocytes
monocytosis refers to
increased circulating monocytes
causes of monocytosis
chronic inflammatory state and malignancy
what is characteristic of young neutrophils from mature neutrophils
decrease number of Fc receptors on immature neutrophils , decrease phagocytosis ability
with leukocytosis how does the bone marrow react
ups if WBC production “left shift”
CD16 is a marker for what about neutrophils
maturity, decreased CD16 = Decreased Fc receptor meaning immature neutrophils
High cortisol state can cause
leukocytosis
neutrophils exist in two groups where are these groups located
marginated pool attached to endothelium ,
and circulating neutrophils in the serum
mechanism for leukocytosis with a high cortisol state
cortisol disrupts neutrophil attachment to endothelium , causing inc lvl of blood neutrophils
eosinophilia is caused by (3)
allergic reactions (hypersensitivity) , parasitic infections, hodgkin lymphoma
increased eosinophilia is mediated by what chemotactic factor
IL-5 , seen in hodgkin lymphoma
basophilia is seen in
CML ( chronic myeloid leukemia )
