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Pathology - Marcel > Wbc, LN, Spleen Thymus > Flashcards

Wbc, LN, Spleen Thymus Flashcards

(77 cards)

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1
Q

How to compute for normal cellularity of bone marrow.

A

100-age

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2
Q

Cause for dose related neutropenia

A

Alkylating agents

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3
Q

Lifespan of neutrophils

A

1-2 days

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4
Q

Produces hypercellular marrow but has blood component production problem

A

Mds and megaloblastic anemia

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5
Q

Type of leukocytosis seen in mds

A

Basophilic

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6
Q

Toxic granules seen in leukocytosis due to severe sepsis

A

Dohle bodies

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7
Q

Tests to differentiate leukemoid reaction from cml

A

Leukocyte alkaline phosphatase and crp. Elevated in leukemoid

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8
Q

Drugs that cause neutropenia

A

Aminopyrine, ptu, chloramphenicol, sulfa drugs, phenylbutazine

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9
Q

Swollen, gray-red and engorged lymph nodes

A

Acute lymph adenitis

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10
Q

Proliferating blast-like b cells seen in follicular hyperplasia

A

Centroblasts

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11
Q

B cells with cleaved nuclear contours

A

Centrocytes

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12
Q

Phagocytic macrophages containing the nuclear debris of b cells

A

Tingible body macrophages

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13
Q

Type of lymph adenitis seen in breast cancer

A

Sinus histiocytosis

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14
Q

Most common cancer in children

A

All

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15
Q

most common all antigen

A

CALLA or cd 10

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16
Q

Translocation on ALL

A

T 12:21

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17
Q

What chemi agent is used or ALL and what is its catastrophic side effect

A

Asparaginas Pancreatitis

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18
Q

Vehicle used to deliver chemo for ALL to cns sanctuary sites

A

Ommaya shunt

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19
Q

Distinctive needle like azurophillic granules seen in aml and apml

A

Auer rods

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20
Q

Antigen profile of aml

A

Mpo cd 33 and cd 34 positive

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21
Q

Translocation seen in apml

A

T 15:17

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22
Q

Treatment for apml

A

All trans retinoic acid

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23
Q

Translocation in aml

A

T 9:22

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24
Q

Scattered macrophages with abundant wrinkled green blue cytoplasm seen in cml

A

Sea-blue histiocytes

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25
Asymptomatic phase of cml
Chronic phase
26
Phase of cml where disease is progressing. 10-19% myeloblasts in bone marrow
Accelerated phase
27
Final phase of cml. >20% myeloblast in bm
Blast crisis
28
Treatment for cml. side effect
Imatinib. Fluid retention. Chf
29
Absolute lymphocyte count of cll
>4000
30
Absolute lymphocyte count of sll
31
Most commob leukemia of adults and elderly
CLL
32
Small lymphocytes disrupted in the process of making smears. Seen in CLL
Smudge cells
33
Transformation of CLL into diffuse large b cell lymphoma
Richter syndrome
34
Hairy cell leukemia is stained using
Tartrate resistant acid phosphatase (trap)
35
Main neoplastic cell in hodgkins lymphoma
Reed sternberg cell
36
Involvement of mesenteric nodes and the waldeyer's ring is seen in
Non hodgkins lymphoma
37
Antigenic profile of hodgkins lymphoma
Positive for cd 15 and 30
38
Type hodgkins lymphoma with poorest prognosis.
Leukocyte depleted
39
Type of hodgkins lymphlma with best prognosis
Lymphocyte rich
40
Type of hodgkins lymphoma related to ebv infection
Lymphocyte depleted > mixed cellularity > lymphocyte rich
41
Most common type of hodgkins lymphoma associates with formation of collagen bands
Nodular sclerosis
42
Type of hodgkins that does not stain with cd 15 and 30
Lymphocyte predominant
43
Paraneoplastic syndrome seen in patients with hodgkins lymphoma who drink alcohol
Painful lymph nodes
44
Most common hematopoetic malignancy
NHL
45
Most common form of NHL
DLBCL
46
T 14:18
Follicullar lymphoma
47
Burkitts lymphoma is associated with translocation of what gene.
C myc gene
48
Cellular pattern seen in burkitts lymphoma
Starry night pattern
49
Infection associated woth burkitts lymphoma
Ebv
50
High levels of cyclin D1 is expressed in
Mantle cell lymphoma
51
Translocation in mantle cell lymphoma
T 11:14
52
Malignancy of cd4+ t cells
Adult t cell lymphoma
53
Adult t cell lymphoma is caused by
Htlv -1
54
Clover leaf or flower cells are seen in what lymphoma
Adult t cell lymphoma
55
Cd 4 cells forming band like aggregates seen in cutaneous t cell lymphoma are called
Sezary-lutzner cells
56
Diffuse erythema and scaling of entire body seen in mycosis fungiodes
Sezary syndrome
57
Aggressive nodular eruptive variant of mycosis fungiodes ( CTCL)
Mycosis fungiodes d'emblee
58
Pautriers microabscesses are seen in
Cutaneous t cell lymphoma
59
Excess light or heavy chain proteins secreted by neoplastic plasma cells
Bence jones proteins
60
Destructive plasma cell tumors involving axial | Skeleton
Plasmacytoma
61
Multiple grapelike cytoplasmic droplets seen in multiple myeloma
Mott cells
62
Blue globular nuclear inclusions seen in multiple myeloma
Dutcher bodies
63
M proteins causes rbcs in pbs to stick in linear arrays by altering the zeta potential in rbcs
Rouleaux conformation
64
Which monoclonal gammopathy has no neoplasm involvement
MGUS
65
Erythroblasts with iron laden mitochondria seen in mds
Ringed sideroblasts
66
Neutrophils with only 2 lobes seen in mds
Pseudo pelger huet cells
67
Megakaryocytes with single nuclear lobes seen in mds
Pawn ball megakaryocytes
68
Mutation seen in polycythemia vera, essential thrombocytosis, and myelofibrosis
Jak2 mutation
69
Treatment of polycythemia vera
Phlebotomy
70
Polycythemia vera has a 2 percent chance to transform to
AML
71
Hallmark of this disease is development of obliterative marrow fibrosis
Primary myelofibrosis
72
Premature release of nucleated erythroid and early granulocyte progenitors seen in primary myelofibrosis
Leukoerythroblastosis
73
Teardrop cells are seen in what disease
Primary myelofibrosis
74
Pentalimar tubules seen in langerhans cell histiocytosis with a tennis racket appearance
Birbeck granules
75
Anemia seen in primary myelofibrosis
Normocytic normochromic
76
Small yellow brown foci called gandy gamma nodules are seen in
Congestive splenomegaly
77
Paraneoplastic syndrome seen in thymoma
Pure red cell aplasia

Pathology - Marcel (2 decks)

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