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HEMA (JUANILLO) > WBC (Malignant) > Flashcards

WBC (Malignant) Flashcards

1
Q

Fatal systemic disease characterized by ________

A

excessive proliferation of clone of immature blood

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2
Q

Derived from hematopoietic stem cells

A

Leukemia

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3
Q

Immature blast cells are accompanied by

A

anemia and thrombocytopenia

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4
Q

specific names depends on the following

A

-tissue which they are found
-cells they are associated
-definitive cells they are produce

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5
Q

Etiology of leukemia

A

-radiation
-chemicals
-genetics/familial disease
-viruses
-primitive immune defects
-myeloproliferative disorders

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6
Q

oncogene

A

encodes protein vital in signal transduction, induction of cancer

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7
Q

chromosomal aberration including aneuploidy and breakage down syndrome

A

trisomy 21

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8
Q

excessive chromosomal breakage

A

fanconi sysndrome

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9
Q

marked chromosal breakage and arrangement

A

bloom syndrome

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10
Q

viruses uses enzyme

A

reverse transcriptase

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11
Q

associated with burkitt lymphoma and IM

A

Epstein barr virus

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12
Q

associated with T cell leukemia and lymphoma

A

Human t cell lymphototorphic virus

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13
Q

proto oncogenes

A

c-abi and c-sis

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14
Q

according to age
acute leukemia
chronic lymphocytic
Chronic grabulocytic

A

below 20
more than 50
20-50

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15
Q

resting lymphocte

A

-low level of dna replication
-poor host for many virus
-gene expression regulated

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16
Q

dividing lymphocyte

A

-high dna replication
-susceptible to potentially
-loss of control over gene expression

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17
Q

Laboratory findings
L1

A

variable wbc count < 20x10^9/L

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18
Q

Laboratory findings
L2

A

elevated wbc count > 20x10^9/L

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19
Q

Laboratory findings
L3

A

normal and elevated wbc count

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20
Q

MPAL

A

mixed phenotype acute leukemia

21
Q

chronic disorder characterized by lymphadenopathy and infiltration of BM and PS by mature lymphocyte

A

CLL

22
Q

most common type of leukemia in western world

A

CLL

23
Q

BINET staging system for CLL
STAGE A

A

no anemia and thrombocytopenia less than 3 lymphoid areas

24
Q

BINET staging system for CLL
STAGE B

A

no anemia and thrombocytopenia more than 3 lymphoid areas

25
Q

BINET staging system for CLL
STAGE C

A

Anemia hb less than 100 g/L and PLT less than 100x10^9

26
Q

signaling molecule used as surrogate marker for IgVH

A

ZAP70

27
Q

wait and see approach

A

CLL

28
Q

long standing given intermittently

A

Chlorambucil

29
Q

6 courses

A

Fludarabine

30
Q

progressive disease which abnormal cells accumulate

A

CLL

31
Q

CLL lab finidng

A

absolute lymphocytosis in blood and lymphocytosis in marro2

32
Q

smudge cells present in

A

CLL

33
Q

LDT

A

blood lymphocyte doubling time

34
Q

transformation of CLL to a large lymphoma, a rapid progressing lethal disease occur in 3-15% with CLL

A

Richter syndrome

35
Q

Variant of CLL describe by Glaton

A

Prolymphocytic Leukemia

36
Q

marked lymphocytosis, prominent splenomegaly without sig lymphadenopathy

A

Prolymphocytic Leukemia

37
Q

lab finding in PLL

A

b cell prolymphocytes, t cell prolymphocytes, WBC count >400,000 . Hgb <12

38
Q

variant of CLL, represents the leukemic phase of folicular or diffuse small, celaved cell lymphoma

A

Lymphosarcoma Cell Leukemia

39
Q

slow progression, splenomegaly, pancytopenia, dry tap

A

Hairy Cell Leukemia

40
Q

monoclonal antibody give positive reaction with hairy cells

A

DBA 44

41
Q

predominance of primitive undifferentiated leukocyte

A

stem cell leukemia

42
Q

neoplastic proliferation of one cell types of lymphopoietic reticular tissue

A

malignant lymphoma

43
Q

4 types based in the extent of lymphocyte infiltration and abundance of reed sternberg

A

Rye classsification

44
Q

similar with rye except for further breakdown of stage III

A

Ann Arbor Staging system

45
Q

based on tumor growth pattern

A

rapoport classification

46
Q

an indolent and includes extranodal tumours like malt

A

Marginal zone lymphoma

47
Q

heterogenous but typically disseminated with marrow involvement

A

mantle cell lymphoma

48
Q
A

HEMA (JUANILLO) (3 decks)

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