Week 1: Introduction to Analgesics/Antipyretics & Treatment of Pain Disorders Flashcards
The brand names of Acetaminophen are ____.
Tylenol, Feverall
The brand names of Ibuprofen are ____.
Motrin, Advil
The brand name of Naproxen sodium is ____.
Aleve
The brand names of Acetylated salicylate are ____.
Aspirin, Bayer, St. Josephs, Ecotrin, ASA
The 2 types of non-acetylated salicylates are ____.
Magnesium salicylate (Doan's) Sodium salicylate (Alka-seltzer)
The MOA of acetaminophen is ____.
central inhibition of prostaglandin synthesis
The MOA of ibuprofen is ____.
- reversible inhibition of COX 1 and COX 2
- inhibition of prostaglandin synthesis
The MOA of naproxen sodium is ____.
- reversible inhibition of COX 1 and COX 2 (Cyclooxygenase)
- inhibition of prostaglandin synthesis
The MOA of salicylates is ____.
- irreversibly inhibits COX-1 and COX-2 (Cyclooxygenase)
- inhibits prostaglandin synthesis
The classes of acetaminophen are ____.
antipyretic , analgesic
for pain and fever - NOT an effective anti-inflammatory agent
The classes of NSAIDs (ibuprofen and naproxen sodium) include ____.
antipyretic, analgesis, AND ANTI-INFLAMMATORY
The therapeutic uses of salicylates include ____.
- cardioprotective (inhibit platelet aggregation)
- primary and secondary prevention of thromboembolism
(stroke or heart attack prevention in high risk patients) - musculoskeletal pain (Topic or systemic)
- headache
- mild/moderate pain
- fever (not in children less than 12 years old or teenagers with a viral illness)
The adult dosing (≥12 yo) for acetaminophen is _____.
325-1,000 mg Q 4-6 hr PRN
Regular strength: 325 mg
Extra strength: 500 mg
The FDA MAX/DAY adult dosing (≥12 yo) for acetaminophen is _____.
4 grams/day (or 4,000 mg)
The MANUFACTURER MAX/DAY adult dosing (≥12 yo) for acetaminophen is _____. Manufacturers voluntarily reduced max/day dose to reduce incidents of hepatotoxicity.
Regular strength: 3,250 mg/day
The OTC adult dosing (≥12 yo) for ibuprofen is _____.
(1-2 tab) 200 mg PO Q 4-6 hrs PRN
The OTC MAX/DAY adult dosing for ibuprofen is _____.
The PRESCRIPTION MAX/DAY adult dosing is ____.
1,200 mg (max 6 tablets/day)
3,200 mg
The OTC adult dosing (≥12 yo) for naproxen sodium is _____.
(1 tab) 220 mg PO Q 8-12 hrs PRN
The OTC MAX/DAY adult dosing (≥12 yo) for naproxen sodium is _____.
The PRESCRIPTION MAX/DAY adult dosing is ____.
660 mg (max 3 tablets/day)
1,500 mg
The adult dose for Aspirin (ASA) dosing used for cardioprotection is _____ daily.
81-162 mg
For an adult dose of Aspirin, you need ____ g/day for anti-inflammatory effect. Note that NSAIDS are a better choice for inflammatory conditions.
4-6
The pediatric based on WEIGHT-BASED dosing for acetaminophen is _____
10-15 mg/kg/dose Q 4-6 hrs PRN
Maximum 5 doses/day
The OTC pediatric dosing for Ibuprofen is ____.
Note: Naproxen is not indicated for children less than 12 years old.
5-10 mg/kg/dose Q 6-8 hrs
Maximum 4 doses/day
The pediatric dosing for naproxen sodium is ____.
NOT indicated for children less than 12 years old
