Week 1 OB Flashcards
(188 cards)
The most common genetic disease among people of African ancestry.
Sickle-cell anemia (R)
Forms rigid crystals that distort and disrupt red blood cells; oxygen-carrying capacity of the blood is diminished
Sickle-cell anemia (R)
The most common genetic disease among people of European ancestry.
Cystic fibrosis (R)
Production of thick mucus clogs in the bronchial tree and pancreatic ducts. Most severe effects are chronic respiratory infections and pulmonary failure.
Cystic fibrosis (R)
The most common genetic disease among people of Jewish ancestry.
Tay-Sachs disease (R)
Degeneration of neurons and the nervous system results in death by the age of 2 years
Tay-Sachs disease (R)
Lack of an enzyme to metabolize the amino acid phenylalanine leads to severe mental and physical retardation. These effects may be prevented by the use of a diet (beginning at birth) that limits phenylalanine.
Phenylketonuria (PKU) (R)
Uncontrollable muscle contractions between the ages of 30 and 50 years, followed by loss of memory and personality. There is no treatment that can delay mental deterioration.
Huntington’s disease (Dominant)
Lack of factor VIII impairs chemical clotting; may be controlled with factor VIII from donated blood.
Hemophilia (X-linked)
Replacement of muscle by adipose or scar tissue, with progressive loss of muscle function; often fatal before age 20 years due to involvement of cardiac muscle.
Duchenne’s muscular dystrophy (X-linked)
Allows for the early detection of genetic disorders such as trisomy 21, hemophilia, and Tay-Sachs disease
Prenatal testing
The developing human is most vulnerable to the effects of teratogens during the period of _____.
organogenesis, the first 8 weeks of gestation
Give an example of a teratogen
Toxoplasmosis
Protozoan parasite found in cat feces and uncooked or rare beef and lamb.
Toxoplasma
When an en embryo is exposed to ______, fetal demise, mental retardation and blindness can result.
Toxoplasma
Education for women who are pregnant or attempting to conceived should:
- Avoid contact with cat feces, such as cleaning or changing a litter box.
- Avoid eating rare beef or lamb.
Exposure to teratogens after 13 weeks of gestation may cause
Fetal growth restriction or reduction of organ size
Give examples of Drugs and Chemicals (Teratogenic Agents)
- Alcohol
- ACE
- Carbamazepine (anticonvulsant)
- Cocaine
- Warfarin (Coumadin)
Alcohol - Characteristics of Fetal Alcohol Syndrome (FAS)
- low birth weight
- microcephaly
- mental retardation
- unusual facial features due to midfacial hypoplasia
- cardiac defects
Increased risk for:
• Renal tubular dysplasia that can lead to renal failure and fetal or neonatal death
• Intrauterine growth restriction
Angiotensin-converting enzyme (ACE) inhibitors
Increased risk for:
• Neural tubal defects
• Craniofacial defects, including cleft lip and palate
• Intrauterine growth restriction
Carbamazepine (anticonvulsant)
Increased risk for:
• Heart, limbs, face, gastrointestinal tract, and genitourinary tract defects
• Cerebral infarctions
• Placental abnormalities
Cocaine
Increased risk for: • Spontaneous abortion • Fetal demise • Fetal or newborn hemorrhage • Central nervous system abnormalities
Warfarin (Coumadin)
Teratogen examples of Infections/Viruses
- Cytomegalovirus
- Herpes varicella (chicken pox)
- Rubella
- Syphilis
- Toxoplasmosis
- Zika