Week 1 OB Flashcards
The most common genetic disease among people of African ancestry.
Sickle-cell anemia (R)
Forms rigid crystals that distort and disrupt red blood cells; oxygen-carrying capacity of the blood is diminished
Sickle-cell anemia (R)
The most common genetic disease among people of European ancestry.
Cystic fibrosis (R)
Production of thick mucus clogs in the bronchial tree and pancreatic ducts. Most severe effects are chronic respiratory infections and pulmonary failure.
Cystic fibrosis (R)
The most common genetic disease among people of Jewish ancestry.
Tay-Sachs disease (R)
Degeneration of neurons and the nervous system results in death by the age of 2 years
Tay-Sachs disease (R)
Lack of an enzyme to metabolize the amino acid phenylalanine leads to severe mental and physical retardation. These effects may be prevented by the use of a diet (beginning at birth) that limits phenylalanine.
Phenylketonuria (PKU) (R)
Uncontrollable muscle contractions between the ages of 30 and 50 years, followed by loss of memory and personality. There is no treatment that can delay mental deterioration.
Huntington’s disease (Dominant)
Lack of factor VIII impairs chemical clotting; may be controlled with factor VIII from donated blood.
Hemophilia (X-linked)
Replacement of muscle by adipose or scar tissue, with progressive loss of muscle function; often fatal before age 20 years due to involvement of cardiac muscle.
Duchenne’s muscular dystrophy (X-linked)
Allows for the early detection of genetic disorders such as trisomy 21, hemophilia, and Tay-Sachs disease
Prenatal testing
The developing human is most vulnerable to the effects of teratogens during the period of _____.
organogenesis, the first 8 weeks of gestation
Give an example of a teratogen
Toxoplasmosis
Protozoan parasite found in cat feces and uncooked or rare beef and lamb.
Toxoplasma
When an en embryo is exposed to ______, fetal demise, mental retardation and blindness can result.
Toxoplasma
Education for women who are pregnant or attempting to conceived should:
- Avoid contact with cat feces, such as cleaning or changing a litter box.
- Avoid eating rare beef or lamb.
Exposure to teratogens after 13 weeks of gestation may cause
Fetal growth restriction or reduction of organ size
Give examples of Drugs and Chemicals (Teratogenic Agents)
- Alcohol
- ACE
- Carbamazepine (anticonvulsant)
- Cocaine
- Warfarin (Coumadin)
Alcohol - Characteristics of Fetal Alcohol Syndrome (FAS)
- low birth weight
- microcephaly
- mental retardation
- unusual facial features due to midfacial hypoplasia
- cardiac defects
Increased risk for:
• Renal tubular dysplasia that can lead to renal failure and fetal or neonatal death
• Intrauterine growth restriction
Angiotensin-converting enzyme (ACE) inhibitors
Increased risk for:
• Neural tubal defects
• Craniofacial defects, including cleft lip and palate
• Intrauterine growth restriction
Carbamazepine (anticonvulsant)
Increased risk for:
• Heart, limbs, face, gastrointestinal tract, and genitourinary tract defects
• Cerebral infarctions
• Placental abnormalities
Cocaine
Increased risk for: • Spontaneous abortion • Fetal demise • Fetal or newborn hemorrhage • Central nervous system abnormalities
Warfarin (Coumadin)
Teratogen examples of Infections/Viruses
- Cytomegalovirus
- Herpes varicella (chicken pox)
- Rubella
- Syphilis
- Toxoplasmosis
- Zika
Increased risk for: • Hydrocephaly • Microcephaly • Cerebral calcification • Mental retardation • Hearing loss
-Cytomegalovirus
Increased risk for:
• Hypoplasia of hands and feet
• Blindness/cataracts
• Mental retardation
-Herpes varicella
Increased risk for: • Heart defects • Deafness and/or blindness • Mental retardation • Fetal demise
-Rubella
Increased risk for:
• Skin, bone, and/or teeth defects
• Fetal demise
-Syphilis
Increased risk for:
• Fetal demise
• Blindness
• Mental retardation
-Toxoplasmosis
Increased risk for: • Microcephaly • Blindness • Hearing defects • Impaired growth
-Zika
Where does fertilization occurs?
Fertilization occurs within one of the two fallopian tubes, also called oviducts
Site of implantation
Uterus
Inner layer of the uterus is called _____.
Endometrium. Each month, estrogen and progesterone stimulate the functional layer to thicken in preparation for egg implantation. If implantation occurs, the endometrium continues to thicken. If implantation does not occur, the functional layer is shed during the menstrual cycle.
Menstrual Cycle 2 Phases
- Ovarian Cycle, 2. Endometrial cycle
____ cycle pertains to the maturation of the ova and consists of 3 phases ____, ____, _____
Ovarian cycle (FOS); 1. follicular phase; 2. ovulatory phase; 3. luteal phase
Phase that begins during the first day of menstruation and lasts 12 to 14 days.
-follicular phase
During this phase, the graafian follicle matures under the influence of two pituitary hormones: ____ and ____. The maturing graafian follicle produces what hormone? _____.
- follicular phase
- 2 pituitary hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- The maturing graafian follicle produces estrogen.
This phase begins when estrogen levels peak and ends with the release of the oocyte (egg) from the mature graafian follicle
Ovulatory Phase
The release of the oocyte is referred to as _____.
Ovulation
LH levels surge 12 to 36 hours before ovulation. Before this surge, estrogen levels decrease and progesterone levels increase.
Ovulatory phase
Begins after ovulation and last approximately 14 days.
Luteal Phase
During this phase, the cells of the empty follicle morph to form the corpus luteum, which produces high levels of progesterone and low levels of estrogen.
Luteal Phase
If pregnancy occurs, the corpus luteum releases progesterone and estrogen until the placenta matures enough to assume this function. If pregnancy does not occur, the corpus luteum degenerates, resulting in a decrease in progesterone and the beginning of menstruation.
Luteal Phase
3 Phases of Endometrial Cycle
PSM = 1. Proliferative Phase, 2. Secretory Phase, 3. Menstrual Phase
This phase occurs following menstruation and ends with ovulation. During this phase, the endometrium prepares for implantation by becoming thicker and more vascular. These changes are in response to the increasing levels of estrogen produce by the graafian follicle
Proliferative Phase
This phase begins after ovulation and ends with the onset of menstruation. In this phase, the endometrium continues to thicken. The primary hormone during this phase is the progesterone secreted from the corpus luteum.
Secretory Phase
If pregnancy occurs, the endometrium continues to develop and begins to secrete glycogen, the energy source for the blastocyst during implantation. If pregnancy does not occur, the corpus luteum begins to degrade and the endometrial tissue degenerates.
Secretory Phase
This phase occurs in response to hormonal changes and results in the sloughing off and expulsion of the endometrial tissue.
Menstrual phase
Conception aka as _____, occurs when a sperm nucleus enters the nucleus
Fertilization
Heart begins to beat during ____.
3rd week after conception
3 Fetal Circulation
- ductus venosus, 2. foramen ovale, 3. ductus arteriosus
It connects the pulmonary artery with the descending aorta.
Ductus arteriosus
It connects the umbilical vein to the inferior vena cava. This allows the majority of the highly oxygenated blood to enter the right atrium.
ductus venosus
It is an opening between the right and left atria. It may take up to 3 months for full closure.
foramen ovale
- Red blood cells are produced in the liver.
- Fusion of the palate is completed.
- External genitalia are developed to the point that sex of fetus can be noted with ultrasound.
- Eyelids are closed.
- Fetal heart tone can be heard by Doppler device.
Gestational Week 12
- Lanugo is present on head
- Meconium is form in the intestines
- teeth begin to form
- sucking motions are made with the mouth
- skin is transparent
Gestational Week 16
- Lanugo covers the entire body
- Venix caseosa covers the body
- Nails are formed
- Brown fats begin to develop
Gestational Week 20
- Eyes are developed.
- Alveoli form in the lungs and begin to produce surfactant.
- Footprints and fingerprints are forming.
- Respiratory movement can be detected.
Gestational Week 24
Eyelids are open. Adipose tissue develops rapidly. The respiratory system has developed to a point where gas exchange is possible, but lungs are not fully mature.
Gestational Week 28
Bones are fully developed. Lungs are maturing. Increased amounts of adipose tissue are present.
Gestational Week 32
Lanugo begins to disappear. Labia majora and minora are equally prominent. Testes are in upper portion of scrotum.
Gestational Week 36
Fetus is considered full term at 38 weeks. All organs/systems are fully developed.
Gestational Week 40
2 Functions of the placenta
- Metabolic and gas exchange -In the placenta, fetal waste products and CO2 are transferred from the fetal blood into the maternal blood sinuses by diffusion. Nutrients such as glucose and amino acids and O2 are transferred from the maternal blood sinuses to the fetal blood through the mechanisms of diffuse and active transport.
2 Functions of the placenta
- Hormone Production: The major hormones the placenta produces are progesterone; estrogen; human chorionic gonadotropin (hCG); and human placental lactogen (hPL), also known as human chorionic somatomammotropin.
4 hormones of the placenta:
Progesterone, Estrogen, hCg, hPL
Function of the progesterone in the placenta
Progesterone facilitates implantation and decreases uterine contractility.
Function of the estrogen in the placenta
Estrogen stimulates the enlargement of the breasts and uterus.
Function of the hCG in the placenta
hCG stimulates the corpus luteum so that it will continue to secrete estrogen and progesterone until the placenta is mature enough to do so. This is the hormone assessed in pregnancy tests. hCG rises rapidly during the first trimester and then rapidly declines.
Function of the hPL in the placenta
hPL promotes fetal growth by regulating available glucose and stimulates breast development in preparation for lactation.
What can cross the placenta?
- viruses such as rubella and cytomegaloviruses
- drugs/avoid preg category C, D, or X.
Function of the Embryonic Membranes
The intact membranes help maintain a sterile environment by forming a barrier that prevents bacteria from entering the amniotic fluid through the vagina.
Contained within the amniotic sac. It is clear and is mainly composed of water. It also contains proteins, carbohydrates, lipids, electrolytes, fetal cells, lanugo, and vernix caseosa.
Amniotic fluid
4 Functions of Amniotic Fluid
● Cushions the fetus from sudden maternal movements.
● Prevents the developing human from adhering to the amniotic membranes.
● Allows freedom of fetal movement, which aids in symmetrical musculoskeletal development.
● Provides a consistent thermal environment.
2 types of amniotic fluid abnormalities
- Polyhydramnios or hydramnios
2. Oligohydramnios
Refers to excess amount of amniotic fluid (1,500–2,000 mL). Newborns of mothers who experience polyhydramnios have an increased incidence of chromosomal disorders and gastrointestinal, cardiac, and neural tube disorders.
Polyhydramnios or hydramnios