Week 10 - Keratoconus Flashcards

1
Q

Describe Keratoconus

A

• Definition: Non-inflammatory, progressive ectasia (distortion) of the cornea causing an irregular, thinned corneal shape and therefore blurred vision.

• Incidence: 1 in 3000 to 1 in 10,000 depending on ethnicity

• Age of onset: typically late teens or early twenties

• Usually bilateral but often asymmetric

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2
Q

Risk factors/associations with Keratoconus

A

• Asian ethnicity
• Family History
• Collagen/connective tissue disorders
• Atopy
• Eye rubbing

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3
Q

Sub clinical keratoconus:

A
  • No signs on slit lamp examination
  • Unaided vision 6/6 or better
  • Patient asymptomatic
  • Retinoscopy reflex may be a little irregular
  • Mild thinning & irregularity on topography
  • May go undetected/undiagnosed
    GCU
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4
Q

Early Keratoconus:

A

• No signs on slit lamp examination or subtle Vogts’s striae; (fine stress mark-like folds in the Posterior stroma)
• Subtle thinning of corneal section
• Fleischer’s ring; (iron deposits at base of cone)
• Mild scissor ret reflex
• Low myopic/astigmatic Rx
- VA refracts well
- Pachymetry under 550 microns

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5
Q

Moderate Keratoconus:

A

• Very split/scissors ret reflex
• Oil droplet reflex
• Moderate - high myopia and astigmatism.
• Difficult end point on refraction
• VA poor
• Pachymetry under 450 microns - thinning seen on corneal section

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6
Q

Advanced Keratoconus

A

• No useful ret reflex as cornea so distorted
• Poor VA
• Munsen’s sign
• Hydrops - breaks in Descemets membrane causing oedema, which resolves with scarring
• CCT under 440microns

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7
Q

Differential diagnosis for keratoconus:

A

• Pellucid marginal degeneration
• Keratoglobus
• Post Lasik/Lasek ectasia

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8
Q

Presentation of keratoconus:

A

• Blurred or poor quality vision
• Frequent changes in prescription recently, particularly with increasing myopia/astigmatism
• Dissatisfaction with glasses or with previous optometrist
• Monocular diplopia or ghosting
• Glare

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9
Q

Investigations of keratoconus:

A

• Refraction with retinoscopy
• Slit lamp examinatiom
• Pachymetry (average normal cornea 550microns)
• Keratometry (normal range 7.10- 8.60)
Are the mires distorted?

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10
Q

What options can be considered with karatoconus?

A

• Prescribe glasses but warn x may change
Consider partial x or balance lens if high cyls and/or significant anisometropia
• Refer routinely to local cornea service
• Consider contact lenses

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11
Q

What are the steps from a hospital eye dept?

A

• Patient assessed with refraction, topography and dilated ocular examination - diagnosis made
(Mild-Mod CCT>400)
• Repeat assessment
3-4 months later to see if KC has progressed
- Progressive: List for collagen cross linking
- Stable: Continue to monitor every 6-12 months for 5 years
(Advanced, CCT<400, scarring)
• Fit contact lenses if indicated
• If CLs unsuccessful consider graft

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12
Q

Corneal collagen cross linking (CXL) aim:

A

• AIM: To stop progression of keratoconus (and other ectasias). Success rate >90% DOES NOT CURE KERATOCONUS OR IMPROVE THE IRREGULARITY - IT JUST STOPS IT GETTING WORSE

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13
Q

Corneal collagen cross linking (CXL) procedure:

A

PROCEDURE: Epithelium removed with alcohol, riboflavin 0.1% (vitamin B2) drops applied to stroma for 10 mins, exposed stroma irradiated with pulsed UV light (every 1.5secs for 8 mins)
- this strengthens bonds between collagen fibres of cornea. Bandage contact lens applied, post op drops prescribed. Usually done as day surgery under local anaesthetic.

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14
Q

Before vs after CXL?

A

• Before: Weaker bonds in collagen
• After: Stronger bonds in collagen

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15
Q

Why not cross link everyone with KC?

A
  1. No progression = no point in crosslinking!
  2. Risks!
    - Infection
    - Scarring/haze
    - Poor healing of epithelium
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16
Q

Exclusion criteria for CXL:

A

-No progression
-CCT under 400 microns
-Corneal scarring
- Caution taken if facial/periorbital eczema - higher complication risk
- Re-treatment possible on same eye in CCT still > 400

17
Q

Corneal graft/transplant:

A

• Corneal Graft / Transplant: Penetrating
- Life long risk of grafted tissue rejecting
- Long recovery (12-18 months) before tissue stable
- Long term topical steroid use
- Often results in regular or irregular astigmatism of the graft surface, meaning the need for glasses x with high cyls/anisometropia or the need for post graft contact lenses.

18
Q

Penetrating keratoplasty steps:

A
  1. Diseases or injured cornea
  2. Corneal button removed
  3. Clear donor button
  4. Donor cornea sutured in place
19
Q

Deep anterior lamellar keratoplasty “DALK”

A

• Lower risk of graft failure as patient keeps their own endothelium
• Similar refractive outcome to PK

20
Q

Other surgical options:

A

• INTACS or Kerarings
Intra-stromal ring implants
• No longer offered on NHS due to inconsistent results.
• CXL Plus
- Crosslinking with laser correction of
irregularity
- Not offered on NHS

21
Q

Contact lenses for KC

A

• RGP
• SOFT
• HYBRID (soft exterior, rigid RGP centre)
• Semi-scleral
• Scleral

22
Q

How does RGP help keratoconus?

A

• The images entering through the KC corneal surface create distortion and blurring.
• With RGP: The smooth surface of the RGP contact lens and the tear film layer between the lens and the irregular KC cornea allow a clear image to enter the eye.

23
Q

RGP: Pros

A

• Good acuity, particularly in moderate or advanced eyes
• Long lasting (1 year at least) and can be more cost effective in long term than soft lenses
• Lower risk of infections than soft
• Lower risk of hypoxic complications as good tear exchange and high DK

24
Q

RGP: Cons

A

• Can be difficult to adapt to - initially uncomfortable
• Small and easily lost
• Can displace off cornea in advanced cones
• Apical touch can cause epithelial erosions
• Flare/haloes from lens edge if small diameter
• Fluctuating vision immediately after removal

25
Parameters for RGP:
• BOZR 5.60 - 8.20 mm • BOZD 8.60 - 9.60 mm • BVP usually myopic • Peripheral curves often need to be modified to fit contour of cone (either reduced or increased edge lift around whole lens, or by segment) • Material: -focon • Handling tint: blue, green or violet • Unplanned replacement schedule... Should last a year minimum
26
Three point touch fitting technique:
Four zones created: • Slight apical touch • Paracentral clearance • Mid-peripheral bearing • Peripheral clearance
27
What is Piggybacking RGP lens?
• Piggyback - RGP over plano soft monthly or daily disposable. • Can improve comfort and centration • More hassle for I&R and cleaning, higher risk of complications as px has 2 lenses on eye
28
Soft lenses for keratoconus: Pros
• Good initial tolerance, wear time can be built quickly • Large diameter, flare not problematic • Vision good in mild - moderate KC • Stable fit - don't tend to fall out or displace
29
Soft lenses for keratoconus: Cons
• Don't mask irregularity as well as hard lenses - VA not as good in moderate to advanced KC • Can have thick edges (but silicone hydrogel materials tend to avoid hypoxic problems) • Higher infection risk than with RGPs It can be difficult to ensure stable vision in high cyls
30
Typical Parameters for soft lenses for keratoconus:
• BOZR 7.40mm - 9.40mm • BOZD 14.00mm - 15.50mm • BVP usually myopic with astigmatism - can go up to +/- 30.00DS or -15.00D • Peripheral curves often need to be modified to fit contour of cone (either reduced or increased edge lift around whole lens, or by segment) • Material: -filcon. Tend to be higher modulus than other soft lenses to mask irregularity • Handling tint: none or pale blue • 3-12 months replacement schedule depending on material
31
• Tight/steep soft lenses and • Flat soft lens
• Tight/steep soft lenses - Limbal compression - Hyperaemia often seen after removal • Flat soft lens - Excessive lag on eye movements and blink - Rotation of marking seen - Variable vision - Increase lens awareness
32
Pros and Cons of hybrid lenses:
• PROS - Acuity of RGP but with better comfort Don't displace or fall out like RGPs can • CONS - Can be difficult to insert & remove - Bubbles can form at junction - Solution must be suitable for both materials - Time consuming to fit
33
Describe semi-scleral lens:
• Large diameter RGP material (14-16mm) • Fitted to vault whole cornea with lens resting on sclera • Liquid reservoir between cornea and lens
34
Semi-scleral lens: Pros
• GOOD ACUITY • LESS LID INTERACTION SO CAN BE MORE COMFORTABLE THAN RGPS • TUCKED UNDER LIDS SO NO ISSUES WITH LENSES DISPLACING OR FALLING OUT - GOOD FOR ADVANCED CONES • HELPFUL IF IRREGULAR AREA OF CORNEA VERY PERIPHERAL
35
Semi-scleral lens: Cons
• DIFFICULT TO INSERT AND REMOVE - HAVE TO GO IN FULL OF SALINE, REMOVED LIKE A BIG RGP OR WITH SUCKER • DIFFICULT TO JUDGE FIT - PX HAS TO INSERT WITH SALINE WITH ADDED FLUOROSCEIN AS THERE IS NO TEAR EXCHANGE • HAVE TO ENSURE LIMBAL HEALTH ISN'T COMPROMISED • NOT IDEAL IF INFLAMMATION OF OCULAR SURFACE AS NO TEAR EXCHANGE
36
Considerations when fitting:
• Atopic/allergic keratoconjunctivitis. A lot of patients with keratoconus have seasonal or year-round dust, animal hair or pollen allergies • Always take a medical and ocular history at the start of the fit appointment. • Examine the tarsal plate by everting the lids • Consider starting patient on topical antihistamines or mast cell stabilisers before proceeding with fitting to get any ocular allergy under control • Explain any potential problems to the patient
37
Considerations in fitting lenses for amount worn:
• Patients could be wearing lenses for the next 50 years! • CLAPC, hypoxia or dry eye could be an issue • Patients who are attending for topography every 6 -12 months to check for progression have to leave their lenses out for 2 weeks prior to topography to ensure scans are accurate.