Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

advanced Pharm > week 2 PNS > Flashcards

week 2 PNS Flashcards

1
Q

all pre ganglion neuron in PNS

A

acetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

all post ganglion neuron in the PNS, except sweat gland

A

Norepinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

major neurotransmitter release by the adrenal medulla

A

epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

primary receptor type in the peripheral nervous system

A

cholinergic and adrenergic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

three type of cholinergic receptor

A

Nicotinic N
Nicotinic M
Muscarinic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

four type of adrenergic receptor

A

alpha 1
alpha 2
beta 1
beta 2
dopamine *

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

location of Nicotinic N receptor

A

cell body of all post-ganglion neuron

cell of adrenal medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

location of Nicotinic M receptor

A

skeletal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

location of muscarinic receptor

A

all organs regulated by parasympathetic nervous system

sweat gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

alpha , beta receptor located on

A

all organs regulated by then sympathetic nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

function of nicotinic M receptor on neuromuscular junction

A

contract skeletal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

functions of muscarinic receptor on the. eyes

A

contract the ciliary muscle, focus on the sense for near vision

contract he iris cause mitosis ( pupil constriction)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

function of muscarinic receptor on the heart

A

decrease HR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

function of muscarinic receptor on then lungs

A

constriction of bronchi
promotes secretions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

function of muscarinic receptor on the bladder

A

constriction of destrusor increase bladder pressure

relax the sphincter allow urine to leave the bladder

cause voiding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

function of muscarinic receptor on the GI track

A

salivation
increase gastric secretion
increase motility
defecation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

function of muscarinic receptor on the blood vessel

A

vasodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

function of Alpha 1 receptor on the eye

A

constrict the radial muscle of iris cause mydriasis ( pupil dilation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

alpha 1 receptor on arterioles skin
veins, prostatic capsule, and bladder

A

constriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

function of alpha 2 receptor on presynaptic nerve terminal

A

inhibits the release of transmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

function of beta 1 receptor on the heart

A

inc heart rate,
inc force contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

function of the beta 1 receptor on the kidney

A

release renin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

function of the beta 2 receptor on the arterioles
heart
lung
bronchi

A

dilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

function of beta 2 receptor on uterus

A

relaxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
function of the beta 2 receptor on the liver
Glycogen lysis
26
function of beta 2 receptor on skeleton muscle
enhance contraction glycogen lysis
27
what type receptors does epinephrine activates
alpha 1, 2 beta 1,2
28
what type receptors does norepinephrine activates
alpha 1, 2 beta 1
29
what types of receptors does dopamine activates
alpha 1, beta 1, and dopamine
30
cholinesterase inhibitor
actives cholinergic receptor indirectly by preventing the break down of acetylcholine
31
cholinesterase inhibitor
actives cholinergic receptor indirectly by preventing the break down of acetylcholine
32
muscarinic agonist
mimic acetylcholine at muscarinic receptor
33
Bethanechol ( Urecholine)
muscarinic agonist binds to the muscarinic receptor cause activation relieve urine retention by constrict detrusor muscle and relax bladder sphincter result in bladder emptying off label for treating GERD, and GI paralysis by increase tone motility of the GI tract pupillary constriction (moisis ) and constrict ciliary muscle hence alters the curvature of the lease result in accommodation for near vision
34
Pilocarpine (isoptocarpine)
muscarinic agonist use for topical therapy in treating glaucoma or oral form to treat dry mouth for PT with Sjogren
35
adverse effect of Bethanechol
hypotension and bradycardia excessive salivation, increase production of gastric acid risk of bladder wall rupture and exacerbate asthma
36
Cevileline ( Evoxac)
muscarinic agonist treat xerostomia (dry mouth) for pt with Sjogren syndrome or going thru radiation therapy adverse effect excessive sweating blurry vison
37
Muscarinic (Cholinergic ) Toxicity
DUMBELS Diaphoresis , diarrhea Urination Mitosis Bradycardia brochospasm Emesis Lacrimation Salivation TX Atropine
38
what are the two categories of cholinesterase inhibitor
reservable inhibitor irreversible inhibitor
39
pyridostigmine
reversible cholinesterase inhibitor drug of choice management of myasthenia gravis carries a + charge, can not cross brain blood barrier, absorb poorly after PO admin, hence minimal effect on the brain and Fetus MOA - binds to cholinesterase, hence it decrease the amount of acetylcholine cholinesterase breaks down pharmacological effect - bradycardia, bronchial constriction, urinary urgency, increase tone and motility of GI track, meiosis and focus the lens for near vision, increase tone of muscle contraction *excessive amount of acetyl at NMJ will cause neuromuscular blockade contradiction - GI obstruction, urinary obstruction, asthma, peptic ulcer disease and hyperthyroidism ( causes dysrhythmia )
40
common cholinesterase inhibitors
Neostigmine physostigmine pyridostigmine
41
cholinesterase inhibitors that are for treating Alzheimer
donepezil ( aricept ) galantamine rivastigmine
42
irreversible cholinesterase inhibitor
use for treatment if glaucoma
43
Myasthenic crisis VS Cholinergic Crisis
Myasthenic crisis- A state of extreme muscle weakness cause by insufficient acetylcholine at the NMJ, can result in death due to paralysis of respiratory muscle TX- Neostigmine cholinergic crisis - also characterized by extreme muscle weakness, accompanied by excessive muscarinic stimulation TX atropin
44
Edrophonium
ultrashort- acting cholinesterase inhibitor, use to differentiate myasthenic crisis and cholinergic crisis
45
atropine
muscarinic antagonist competitive blockade muscarinic receptor preventing receptor activation by endogenous acetylcholine pharmacological effect inc HR, decrease secretion from salivary gland, brocchial gland, sweat glad and GI decrease tone and motility of GI tack and urinary bladder cause dilation of the pupil tx for sinus bradycardia and AV block , antidote for anticholinesterase poisoning
46
adverse effect of Bethanechol
hypotension and bradycardia excessive salivation, increase production of gastric acid risk of bladder wall rupture and exacerbate asthma
47
M3 Muscarinic receptor blocker that use to treat overactive bladder
Darifenacin ( highly M3 selective ) Oxybutynin (primary selective ) Tolterodine (nonselective ) Fesosterodine
48
Anti-muscarinic (Anti-cholinergic ) toxicity
HOT hyperthermia DRY dry eye, dry mouth dry skin RED flushed face BLIND mydriasis MAD delirium TX physostigmine
49
mechanism of adrenergic receptor activation
direct binding promotion of norepinephrine release inhibitor of norepinephrine reputate inhibition of norepinephrine inactivation
50
adverse effect of Bethanechol
hypotension and bradycardia excessive salivation, increase production of gastric acid risk of bladder wall rupture and exacerbate asthma
51
adverse effect of Bethanechol
hypotension and bradycardia excessive salivation, increase production of gastric acid risk of bladder wall rupture and exacerbate asthma
52
NE, dopamine and dobutamine can only be administered by what route
continuous infusion due to rapidly inactivation by MAO and COMT in the liver and intestine wall
53
therapeutic application of a1 activation
evaluation of blood pressure hemostasis (stop bleeding ) nasal decongestion delay anesthetic absorption
54
adverse effect of a1 activation
hypertension reflex bradycardia necrosis (when IV extravasates)
55
clinical application of B1 activation
heart failure shock AV block cardiac arrest
56
adverse effect of B1 activation
tachycardia dysthymia angina
57
therapeutic application of B2 activation
asthma ( albuterol , isoproterenol ) delay preterm labor
58
adverse effect of B2 activation
hyperglycemia tremor
59
epinephrine
binds to a1 receptor cause - vasoconstriction hence elevated bp, controlled bleeding binds B1 receptor, increase Cardiac contractility, VF, asystole , increase CO, used in cardiac arrest, and may be use to overcome AV block binds B2 to promotes brochodialation treatment for anaphylactic shock
60
list of adrenergic agonist
epinephrine Norepinephrine isoproterenol dopamine dobutamine phenylephrine albuterol ephedrine
61
difference between epinephrine and norepinephrine
NE doesn’t activate B2 receptor hence doesn’t cause hyperglycemia limited clinical use, only use in severe hypotensive crisis and cardia arrest

advanced Pharm (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions