Week 4 Local Anesthetics

Question 1

Local Anesthetic Definition

Answer 1

drugs that reversibly block conduction of electrical impulses along nerve fibers

Question 2

What are LA utilized for?

Answer 2

chronic and acute pain

major component of clinical anesthesia

Question 3

Nerve Anatomy includes

Answer 3

the axon and extension of the neuron is the functional of peripheral nerves

Question 4

nerves are considered

Answer 4

myelinated or unmyelinated based on type of axon covering

Question 5

What are the major components of the nerve?

Answer 5

axolemma
axoplasm
schwann cells surround each neuron

Question 6

Schwann cells

Answer 6

serve to support and insulate each axon

Question 7

Unmyelinated nerves

Answer 7

smaller nerves

single schwann cells cover several axons

Question 8

Myelinated nerves

Answer 8

larger nerves

schwann cells covers only one axon and has several concentric layers of myelin

Question 9

Nodes of Ranvier

Answer 9

periodic segments between schwann cells along the axon that do not contain myelin

Question 10

Primary site of LA action

Answer 10

voltage-gated sodium channels are located in nodes of ranvier segments
action potentials jump from nerve to nerve
saltatory conduction

Question 11

To block impulses in myelinated fibers it is neccessary for LA to

Answer 11

inhibit channels in three successive nodes

Question 12

Fasciculi are

Answer 12

bundles of axons