Week 6: Pharma

Question 1

Describe azoles as a drug class

Answer 1

antifungal medications that disrupt the synthesis of ergosterol (component of fungal cell membranes). Divided into imidazoles and triazoles

Question 2

Class of fluconazole, itraconazole, ketoconazole, clotrimazole, miconazole, voriconazole

Answer 2

Azole (antifungals)

Question 3

MOA of fluconazole, itraconazole, ketoconazole, clotrimazole, miconazole, voriconazole

Answer 3

Interferes with ergosterol synthesis to inhibit cell membrane function

Question 4

Side effects of Azoles

Answer 4

Headache, GI upset
Rare/serious: hepatotoxicity, prolonged QT, SJS, TEN, DRESS

Question 5

What is most commonly used for seborrheic dermatitis, tinea versicolor

Answer 5

Ketoconazole

Question 6

What is most commonly used for yeast infection

Answer 6

Fluconazole